Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice

Spontaneous mutations in the SHANK-associated RH domain interacting protein (Sharpin) resulted in a severe autoinflammatory type of chronic proliferative dermatitis, inflammation in other organs, and lymphoid organ defects. To determine whether cell-type restricted loss of Sharpin causes similar les...

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Veröffentlicht in:	PloS one 2020-07, Vol.15 (7), p.e0235295
Hauptverfasser:	Sundberg, John P, Pratt, C Herbert, Goodwin, Leslie P, Silva, Kathleen A, Kennedy, Victoria E, Potter, Christopher S, Dunham, Anisa, Sundberg, Beth A, HogenEsch, Harm
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Arthritis Arthritis - genetics Arthritis - pathology Atopic dermatitis Biology and Life Sciences Cell culture Defects Dendritic cells Dermatitis Dermatitis, Atopic - genetics Dermatitis, Atopic - pathology Disease Disease Models, Animal Eczema Fibroblasts Gene deletion Gene Expression Regulation - genetics Genotype & phenotype Humans Immunoglobulin E Immunoglobulin E - genetics Inflammation Inflammation - genetics Inflammation - pathology Integrases - genetics Interleukin 1 Interleukin 18 Interleukin-18 - genetics Keratin-14 - genetics Keratinocytes Keratinocytes - metabolism Keratinocytes - pathology Laboratory animals Lesions Leukocytes (eosinophilic) Medicine and Health Sciences Mice Mutants Mutation Nerve Tissue Proteins - genetics NF-kappa B - genetics NF-κB protein Organs Phenotype Phenotypes Physiological aspects Proteins Recombinase Research and Analysis Methods Rodents S100 Calcium-Binding Protein A4 - genetics S100A4 protein Signal Transduction Skin diseases Skin lesions Veterinary colleges Veterinary medicine
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