Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral components and due to the host response from detection...
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| Veröffentlicht in: | PloS one 2020-07, Vol.15 (7), p.e0236195-e0236195 |
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| creator | Stairiker, Christopher J van Meurs, Marjan Leon, Leticia G Brouwers-Haspels, A. A Rijsbergen, Laurine Mueller, Yvonne M Katsikis, Peter D |
| description | During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral components and due to the host response from detection of viral products. In the advent of RNA sequencing, the discovery of new genes and their functions in the host response generates new avenues for interventions in the host-pathogen interaction. We have identified a novel gene, Heatr9, as a virus and cytokine inducible viral responsive gene. We confirm Heatr9's expression in vitro and in vivo during virus infection and correlate it with viral burden. Heatr9 is induced by influenza virus and RSV. Heatr9 knockdown during viral infection was shown to affect chemokine expression. Our studies identify Heatr9 as a novel inflammatory and virus infection induced gene that can regulate the induction of specific cytokines. |
| doi_str_mv | 10.1371/journal.pone.0236195 |
| format | Article |
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A ; Rijsbergen, Laurine ; Mueller, Yvonne M ; Katsikis, Peter D</creator><creatorcontrib>Stairiker, Christopher J ; van Meurs, Marjan ; Leon, Leticia G ; Brouwers-Haspels, A. A ; Rijsbergen, Laurine ; Mueller, Yvonne M ; Katsikis, Peter D</creatorcontrib><description>During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral components and due to the host response from detection of viral products. In the advent of RNA sequencing, the discovery of new genes and their functions in the host response generates new avenues for interventions in the host-pathogen interaction. We have identified a novel gene, Heatr9, as a virus and cytokine inducible viral responsive gene. We confirm Heatr9's expression in vitro and in vivo during virus infection and correlate it with viral burden. Heatr9 is induced by influenza virus and RSV. Heatr9 knockdown during viral infection was shown to affect chemokine expression. Our studies identify Heatr9 as a novel inflammatory and virus infection induced gene that can regulate the induction of specific cytokines.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236195</identifier><identifier>PMID: 32678841</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Alveoli ; Animal protection ; Animal welfare ; Biology and life sciences ; Chemokines ; Cytokines ; Development and progression ; Epithelial cells ; Gene expression ; Gene sequencing ; Genes ; Genetic aspects ; Health aspects ; Host-pathogen interactions ; Identification and classification ; Immune response ; Immunology ; Infections ; Inflammation ; Influenza ; Influenza viruses ; Laboratory animals ; Lungs ; Medical schools ; Medicine ; Medicine and Health Sciences ; Phosphatase ; Physiological aspects ; Proteins ; Pulmonary alveoli ; Regulatory genes ; Research and Analysis Methods ; Respiratory syncytial virus ; Ribonucleic acid ; RNA ; Viral infections ; Virions ; Virus diseases ; Viruses</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0236195-e0236195</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Stairiker et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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We confirm Heatr9's expression in vitro and in vivo during virus infection and correlate it with viral burden. Heatr9 is induced by influenza virus and RSV. Heatr9 knockdown during viral infection was shown to affect chemokine expression. Our studies identify Heatr9 as a novel inflammatory and virus infection induced gene that can regulate the induction of specific cytokines.</description><subject>Alveoli</subject><subject>Animal protection</subject><subject>Animal welfare</subject><subject>Biology and life sciences</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Epithelial cells</subject><subject>Gene expression</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Host-pathogen interactions</subject><subject>Identification and classification</subject><subject>Immune response</subject><subject>Immunology</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Influenza</subject><subject>Influenza viruses</subject><subject>Laboratory animals</subject><subject>Lungs</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Phosphatase</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Pulmonary alveoli</subject><subject>Regulatory genes</subject><subject>Research and Analysis Methods</subject><subject>Respiratory syncytial virus</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Viral infections</subject><subject>Virions</subject><subject>Virus diseases</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99rFDEQxxdRbK3-B4ILgujDnckmm2RfhFLUHhQK_noNs9nZu9Tc5kyyh_3vzXqndKUPkockk898JzPJFMVzSpaUSfr2xo9hALfc-QGXpGKCNvWD4pQ2rFqIirCHd9YnxZMYbwipmRLicXHCKiGV4vS06C4RUmhKG0sYSjv0aJL1QxkwZuFo91iuccAybSCV0E_HsTS3yX-32boLvhsPDnYowe3ROwgl7mzaoLPgSoPOxafFox5cxGfH-az4-uH9l4vLxdX1x9XF-dXC1IrXC1W3RrHKCMWokS2V2Mi64i0S6CQjNa0V1q0AQQ0jXS_zngtsWNs3hhpl2Fnx4qC7cz7qY4GirnjFBVeU0UysDkTn4Ubvgt1CuNUerP5t8GGtISRrHGqQArGrK9aplvOKNi10gvSya2sAJUXWeneMNrZb7AwOKYCbic5PBrvRa7_XkgnJ1STw-igQ_I8RY9JbG6eCwYB-PNy7aTiRTUZf_oPen92RWkNOID-mz3HNJKrPRdXIHJjITC3vofLocGtN_k29zfaZw5uZQ2YS_kxrGGPUq8-f_p-9_jZnX91hNwgubaJ34_Sf4hzkB9AEH2PA_m-RKdFTM_yphp6aQR-bgf0CHn367w</recordid><startdate>20200717</startdate><enddate>20200717</enddate><creator>Stairiker, Christopher J</creator><creator>van Meurs, Marjan</creator><creator>Leon, Leticia G</creator><creator>Brouwers-Haspels, A. 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| subjects | Alveoli Animal protection Animal welfare Biology and life sciences Chemokines Cytokines Development and progression Epithelial cells Gene expression Gene sequencing Genes Genetic aspects Health aspects Host-pathogen interactions Identification and classification Immune response Immunology Infections Inflammation Influenza Influenza viruses Laboratory animals Lungs Medical schools Medicine Medicine and Health Sciences Phosphatase Physiological aspects Proteins Pulmonary alveoli Regulatory genes Research and Analysis Methods Respiratory syncytial virus Ribonucleic acid RNA Viral infections Virions Virus diseases Viruses |
| title | Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells |
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