Age-of-onset information helps identify 76 genetic variants associated with allergic disease

Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, h...

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Veröffentlicht in:	PLoS genetics 2020-06, Vol.16 (6), p.e1008725
Hauptverfasser:	Ferreira, Manuel A R, Vonk, Judith M, Baurecht, Hansjörg, Marenholz, Ingo, Tian, Chao, Hoffman, Joshua D, Helmer, Quinta, Tillander, Annika, Ullemar, Vilhelmina, Lu, Yi, Grosche, Sarah, Rüschendorf, Franz, Granell, Raquel, Brumpton, Ben M, Fritsche, Lars G, Bhatta, Laxmi, Gabrielsen, Maiken E, Nielsen, Jonas B, Zhou, Wei, Hveem, Kristian, Langhammer, Arnulf, Holmen, Oddgeir L, Løset, Mari, Abecasis, Gonçalo R, Willer, Cristen J, Emami, Nima C, Cavazos, Taylor B, Witte, John S, Szwajda, Agnieszka, Hinds, David A, Hübner, Norbert, Weidinger, Stephan, Magnusson, Patrik Ke, Jorgenson, Eric, Karlsson, Robert, Paternoster, Lavinia, Boomsma, Dorret I, Almqvist, Catarina, Lee, Young-Ae, Koppelman, Gerard H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Age of Onset Aged Allergic diseases Allergy Asthma Asthma - genetics Asthma - pathology Biology and Life Sciences Bone morphogenetic protein receptor type II Child Dermatology Disease age factors Eczema Eczema - genetics Eczema - pathology Epidemiology Female Food allergies Genetic aspects Genetic diversity Genetic Loci Genetic variation Genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Hay fever Health care Health informatics Health sciences Hospitals Humans Hypersensitivity Identification and classification Internal medicine Male Medicine and Health Sciences Middle Aged NOD2 protein Nursing Pediatrics Phenotypes Polymorphism, Single Nucleotide Preventive medicine Public health Quantitative trait loci Rhinitis, Allergic, Seasonal - genetics Rhinitis, Allergic, Seasonal - pathology Risk factors Smad4 protein
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