Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus

Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to res...

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Veröffentlicht in:	PLoS computational biology 2020-06, Vol.16 (6), p.e1007998
Hauptverfasser:	Eskelinen, Atte S A, Tanska, Petri, Florea, Cristina, Orozco, Gustavo A, Julkunen, Petro, Grodzinsky, Alan J, Korhonen, Rami K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied physics Arthritis Biodegradation Bioengineering Biology and Life Sciences Biomechanics Biomedical materials Biophysics Cartilage Cartilage - injuries Cartilage - metabolism Cartilage diseases Charge density Collagen Complications and side effects Computer applications Computer engineering Computer science Computer simulation Cytokines Cytokines - metabolism Degradation Depletion Electrical engineering Experiments Finite element method Free surfaces Funding Gene expression Homeostasis Humans Inflammation Inflammation Mediators - metabolism Injuries Interleukin Interleukin 1 Interleukins Lesions Mathematical models Mechanical engineering Mechanical properties Medicine and Health Sciences Observations Osteoarthritis Physical Sciences Physiological aspects Proteoglycans Quality of life Research and Analysis Methods Shear strain Software Stress, Mechanical Supervision Tissues
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