GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation

Urogenital tract abnormalities are among the most common congenital defects in humans. Male urogenital development requires Hedgehog-GLI signaling and testicular hormones, but how these pathways interact is unclear. We found that Gli3XtJ mutant mice exhibit cryptorchidism and hypospadias due to loca...

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Veröffentlicht in:	PLoS genetics 2020-06, Vol.16 (6), p.e1008810-e1008810
Hauptverfasser:	Kothandapani, Anbarasi, Lewis, Samantha R, Noel, Jessica L, Zacharski, Abbey, Krellwitz, Kyle, Baines, Anna, Winske, Stephanie, Vezina, Chad M, Kaftanovskaya, Elena M, Agoulnik, Alexander I, Merton, Emily M, Cohn, Martin J, Jorgensen, Joan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Animals Biology and Life Sciences Bladder Congenital defects Cryptorchidism Cryptorchidism - genetics Cryptorchidism - pathology Defects Development and progression Disease Models, Animal Embryonic development Fetuses Funding Gene expression Gene Expression Regulation, Developmental Genetic aspects Health aspects Hedgehog protein Hedgehog proteins Hedgehog Proteins - metabolism Humans Insulin - metabolism Kidneys Leydig cells Leydig Cells - metabolism Leydig Cells - pathology Male Male genital diseases Medicine and Health Sciences Mice Mice, Transgenic Mutants Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Prostate Proteins - metabolism Researchers Sex differentiation Sex Differentiation - genetics Signal Transduction - genetics Supervision Supplementation Supplements Testes Testosterone Testosterone - metabolism Urogenital abnormalities Zinc Finger Protein Gli3 - genetics Zinc Finger Protein Gli3 - metabolism
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