KSHV requires vCyclin to overcome replicative senescence in primary human lymphatic endothelial cells

Kaposi’s Sarcoma Herpesvirus (KSHV) is present in the main tumor cells of Kaposi’s Sarcoma (KS), the spindle cells, which are of endothelial origin. KSHV is also associated with two B-cell lymphomas, Primary Effusion Lymphoma (PEL) and Multicentric Castleman’s Disease. In KS and PEL, KSHV is primari...

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Veröffentlicht in:	PLoS pathogens 2020-06, Vol.16 (6), p.e1008634-e1008634
Hauptverfasser:	DiMaio, Terri A., Vogt, Daniel T., Lagunoff, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	B-cell lymphoma Biology and Life Sciences Cell cycle Cell division Cell proliferation Deoxyribonucleic acid DNA DNA damage Effusion Endothelial cells Endothelium Gene expression Genetic engineering Genomes Homology Infections Kaposi's sarcoma Kaposis sarcoma Latency Lymphocytes B Lymphoma Medicine and Health Sciences Primary effusion lymphoma Proteins Research and Analysis Methods Sarcoma Senescence Software Telomerase Telomeres Tumor cells Tumors
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