System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

Ozonide antimalarials, OZ277 (arterolane) and OZ439 (artefenomel), are synthetic peroxide-based antimalarials with potent activity against the deadliest malaria parasite, Plasmodium falciparum. Here we used a "multi-omics" workflow, in combination with activity-based protein profiling (ABP...

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Veröffentlicht in:	PLoS pathogens 2020-06, Vol.16 (6), p.e1008485
Hauptverfasser:	Giannangelo, Carlo, Siddiqui, Ghizal, De Paoli, Amanda, Anderson, Bethany M, Edgington-Mitchell, Laura E, Charman, Susan A, Creek, Darren J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacology Amino acids Antimalarial activity Antimalarial agents Antimalarials - pharmacology Artemisinin Biochemical analysis Biochemistry Biology and Life Sciences Blood cells Catabolism Damage Data points Datasets Depletion Digestion Erythrocytes Erythrocytes - metabolism Erythrocytes - parasitology Hemoglobin Hemoglobins - genetics Hemoglobins - metabolism Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Heterocyclic Compounds, 1-Ring - pharmacology Humans Lipid metabolism Lipids Malaria Medicine and Health Sciences Metabolism Metabolites Metabolomics Molecular biology Nucleotides Parasite resistance Parasites Peptides Peroxide Peroxides - pharmacology Pharmaceutical sciences Physical Sciences Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - metabolism Proteasomes Protein turnover Proteins Proteomics Red blood cells Spiro Compounds - pharmacology Supervision Time dependence Ubiquitin Vector-borne diseases Workflow
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