Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study
Smoking cessation reduces the cardiovascular risk but increases body weight. We investigated the risk of subsequent myocardial infarction and ischemic stroke according to weight gain after smoking cessation, using a nationwide population based cohort. We enrolled 3,797,572 Korean adults aged over 40...
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| creator | Cho, Jung-Hwan Kwon, Hye-Mi Park, Se-Eun Jung, Jin-Hyung Han, Kyung-Do Park, Yong-Gyu Kim, Yang-Hyun Rhee, Eun-Jung Lee, Won-Young Cummings, Michael |
| description | Smoking cessation reduces the cardiovascular risk but increases body weight. We investigated the risk of subsequent myocardial infarction and ischemic stroke according to weight gain after smoking cessation, using a nationwide population based cohort. We enrolled 3,797,572 Korean adults aged over 40 years who participated in national health screenings between 2009 and 2010. Subjects who quit smoking were classified into three subgroups according to the weight change between baseline and 4 years prior. Myocardial infarctions and ischemic strokes were followed until the end of 2015. We compared the hazard ratios among smoking cessation subgroups, non-smokers, and current smokers. The mean changes in weight (1.5 ± 3.9 kg) of the smoking cessation group were higher than those of the other groups (p < 0.0001). A total of 31,277 and 46,811 subjects were newly diagnosed with myocardial infarction and ischemic stroke, respectively. Regardless of weight change, all subgroups of smoking cessation had significantly less risk than current smokers. The subgroup of smoking cessation with weight gain over 4kg showed the lowest risk for myocardial infarctions (hazard ratio 0.646, 95% confidence interval 0.583-0.714, p < 0.0001) and ischemic strokes (hazard ratio 0.648, 95% confidence interval 0.591-0.71, p < 0.0001) after multivariable adjustment. In conclusion, weight gain after smoking cessation did not adversely affect the cardiovascular protective effect. |
| doi_str_mv | 10.1371/journal.pone.0235276 |
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We investigated the risk of subsequent myocardial infarction and ischemic stroke according to weight gain after smoking cessation, using a nationwide population based cohort. We enrolled 3,797,572 Korean adults aged over 40 years who participated in national health screenings between 2009 and 2010. Subjects who quit smoking were classified into three subgroups according to the weight change between baseline and 4 years prior. Myocardial infarctions and ischemic strokes were followed until the end of 2015. We compared the hazard ratios among smoking cessation subgroups, non-smokers, and current smokers. The mean changes in weight (1.5 ± 3.9 kg) of the smoking cessation group were higher than those of the other groups (p < 0.0001). A total of 31,277 and 46,811 subjects were newly diagnosed with myocardial infarction and ischemic stroke, respectively. Regardless of weight change, all subgroups of smoking cessation had significantly less risk than current smokers. The subgroup of smoking cessation with weight gain over 4kg showed the lowest risk for myocardial infarctions (hazard ratio 0.646, 95% confidence interval 0.583-0.714, p < 0.0001) and ischemic strokes (hazard ratio 0.648, 95% confidence interval 0.591-0.71, p < 0.0001) after multivariable adjustment. In conclusion, weight gain after smoking cessation did not adversely affect the cardiovascular protective effect.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0235276</identifier><identifier>PMID: 32673331</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Blood pressure ; Body mass index ; Body weight ; Body weight gain ; Cardiovascular disease ; Cardiovascular diseases ; Cerebral infarction ; Cigarette smoking ; Cohort analysis ; Confidence intervals ; Diabetes ; Drug addiction ; Endocrinology ; Exercise ; Fasting ; Forecasts and trends ; Glucose ; Health aspects ; Health hazards ; Health risks ; Health sciences ; Heart attack ; Heart attacks ; Hospitals ; Internal medicine ; Ischemia ; Medical schools ; Medical screening ; Medicine ; Medicine and Health Sciences ; Metabolism ; Mortality ; Myocardial infarction ; Obesity ; Physical fitness ; Risk ; Risk factors ; Smoking ; Smoking cessation ; Social Sciences ; Stroke ; Studies ; Subgroups ; Weight gain</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0235276-e0235276</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Cho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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We investigated the risk of subsequent myocardial infarction and ischemic stroke according to weight gain after smoking cessation, using a nationwide population based cohort. We enrolled 3,797,572 Korean adults aged over 40 years who participated in national health screenings between 2009 and 2010. Subjects who quit smoking were classified into three subgroups according to the weight change between baseline and 4 years prior. Myocardial infarctions and ischemic strokes were followed until the end of 2015. We compared the hazard ratios among smoking cessation subgroups, non-smokers, and current smokers. The mean changes in weight (1.5 ± 3.9 kg) of the smoking cessation group were higher than those of the other groups (p < 0.0001). A total of 31,277 and 46,811 subjects were newly diagnosed with myocardial infarction and ischemic stroke, respectively. Regardless of weight change, all subgroups of smoking cessation had significantly less risk than current smokers. The subgroup of smoking cessation with weight gain over 4kg showed the lowest risk for myocardial infarctions (hazard ratio 0.646, 95% confidence interval 0.583-0.714, p < 0.0001) and ischemic strokes (hazard ratio 0.648, 95% confidence interval 0.591-0.71, p < 0.0001) after multivariable adjustment. In conclusion, weight gain after smoking cessation did not adversely affect the cardiovascular protective effect.</description><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cerebral infarction</subject><subject>Cigarette smoking</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Drug addiction</subject><subject>Endocrinology</subject><subject>Exercise</subject><subject>Fasting</subject><subject>Forecasts and trends</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Health hazards</subject><subject>Health risks</subject><subject>Health sciences</subject><subject>Heart attack</subject><subject>Heart attacks</subject><subject>Hospitals</subject><subject>Internal medicine</subject><subject>Ischemia</subject><subject>Medical schools</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Obesity</subject><subject>Physical fitness</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Smoking cessation</subject><subject>Social Sciences</subject><subject>Stroke</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Weight 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effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study</title><author>Cho, Jung-Hwan ; Kwon, Hye-Mi ; Park, Se-Eun ; Jung, Jin-Hyung ; Han, Kyung-Do ; Park, Yong-Gyu ; Kim, Yang-Hyun ; Rhee, Eun-Jung ; Lee, Won-Young ; Cummings, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c735t-73202908c95a326f3d5e81191ad8c686f433ad152d62f28784a1cc63172a3e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cerebral infarction</topic><topic>Cigarette smoking</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>Diabetes</topic><topic>Drug 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Jung-Hwan</au><au>Kwon, Hye-Mi</au><au>Park, Se-Eun</au><au>Jung, Jin-Hyung</au><au>Han, Kyung-Do</au><au>Park, Yong-Gyu</au><au>Kim, Yang-Hyun</au><au>Rhee, Eun-Jung</au><au>Lee, Won-Young</au><au>Cummings, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study</atitle><jtitle>PloS one</jtitle><date>2020-07-16</date><risdate>2020</risdate><volume>15</volume><issue>7</issue><spage>e0235276</spage><epage>e0235276</epage><pages>e0235276-e0235276</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Smoking cessation reduces the cardiovascular risk but increases body weight. We investigated the risk of subsequent myocardial infarction and ischemic stroke according to weight gain after smoking cessation, using a nationwide population based cohort. We enrolled 3,797,572 Korean adults aged over 40 years who participated in national health screenings between 2009 and 2010. Subjects who quit smoking were classified into three subgroups according to the weight change between baseline and 4 years prior. Myocardial infarctions and ischemic strokes were followed until the end of 2015. We compared the hazard ratios among smoking cessation subgroups, non-smokers, and current smokers. The mean changes in weight (1.5 ± 3.9 kg) of the smoking cessation group were higher than those of the other groups (p < 0.0001). A total of 31,277 and 46,811 subjects were newly diagnosed with myocardial infarction and ischemic stroke, respectively. Regardless of weight change, all subgroups of smoking cessation had significantly less risk than current smokers. The subgroup of smoking cessation with weight gain over 4kg showed the lowest risk for myocardial infarctions (hazard ratio 0.646, 95% confidence interval 0.583-0.714, p < 0.0001) and ischemic strokes (hazard ratio 0.648, 95% confidence interval 0.591-0.71, p < 0.0001) after multivariable adjustment. In conclusion, weight gain after smoking cessation did not adversely affect the cardiovascular protective effect.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32673331</pmid><doi>10.1371/journal.pone.0235276</doi><tpages>e0235276</tpages><orcidid>https://orcid.org/0000-0002-1082-7592</orcidid><orcidid>https://orcid.org/0000-0001-8578-2117</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Biology and Life Sciences Blood pressure Body mass index Body weight Body weight gain Cardiovascular disease Cardiovascular diseases Cerebral infarction Cigarette smoking Cohort analysis Confidence intervals Diabetes Drug addiction Endocrinology Exercise Fasting Forecasts and trends Glucose Health aspects Health hazards Health risks Health sciences Heart attack Heart attacks Hospitals Internal medicine Ischemia Medical schools Medical screening Medicine Medicine and Health Sciences Metabolism Mortality Myocardial infarction Obesity Physical fitness Risk Risk factors Smoking Smoking cessation Social Sciences Stroke Studies Subgroups Weight gain |
| title | Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T14%3A02%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effect%20of%20smoking%20cessation%20on%20subsequent%20myocardial%20infarction%20and%20ischemic%20stroke%20independent%20of%20weight%20gain:%20A%20nationwide%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Cho,%20Jung-Hwan&rft.date=2020-07-16&rft.volume=15&rft.issue=7&rft.spage=e0235276&rft.epage=e0235276&rft.pages=e0235276-e0235276&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0235276&rft_dat=%3Cgale_plos_%3EA629662199%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2424386507&rft_id=info:pmid/32673331&rft_galeid=A629662199&rft_doaj_id=oai_doaj_org_article_70a6622527e24a3da093145d85cfc8a6&rfr_iscdi=true |