Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma

The alcohol-abuse drug disulfiram has antitumor effects against diverse cancer types via inhibition of the ubiquitin-proteasome protein nuclear protein localization protein 4 (NPL4). However, the antitumor effects of NPL4 and disulfiram in clear cell renal cell carcinoma (ccRCC) are unclear. Here, w...

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Veröffentlicht in:	PloS one 2020-07, Vol.15 (7), p.e0236119-e0236119
Hauptverfasser:	Yoshino, Hirofumi, Yamada, Yasutoshi, Enokida, Hideki, Osako, Yoichi, Tsuruda, Masafumi, Kuroshima, Kazuki, Sakaguchi, Takashi, Sugita, Satoshi, Tatarano, Shuichi, Nakagawa, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol abuse Aldehyde reductase Antibodies Anticancer properties Antitumor activity Apoptosis Biology and Life Sciences Biosynthesis Cancer Cell adhesion & migration Cell growth Cell proliferation Clear cell-type renal cell carcinoma Disulfiram Drug abuse Drug therapy Enzymes Experiments Gene expression Genomes Health aspects Kidney cancer Kinases Localization Medicine and Health Sciences Metabolism Metabolites Methods Molecular targeted therapy Patients Proteasomes Proteins Reductases Renal cell carcinoma RNA-mediated interference Serine siRNA Survival analysis Ubiquitin Ubiquitin-proteasome system Urology Xenografts Xenotransplantation
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