Simultaneous study of antioxidant activity, DNA protection and anti-inflammatory effect of Vernonia amygdalina leaves extracts
Vernonia amygdalina (VA) has been reported to have antioxidant potential; however, its DNA protection and anti-inflammatory properties remain unclear. We aimed to investigate whether aqueous (WEVAL) and alcoholic (EEVAL) VA extracts exert similar antioxidant, DNA protection and anti-inflammatory eff...
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| description | Vernonia amygdalina (VA) has been reported to have antioxidant potential; however, its DNA protection and anti-inflammatory properties remain unclear. We aimed to investigate whether aqueous (WEVAL) and alcoholic (EEVAL) VA extracts exert similar antioxidant, DNA protection and anti-inflammatory effects and attempted to explore the mechanism underlying the anti-inflammatory effects. These results demonstrated that WEVAL had greater polyphenolic and flavonoid contents, as well as a stronger reducing power, DPPH radical scavenging and DNA protective activity. Moreover, both extracts reduced lipopolysaccharide (LPS)-induced expression of COX-II, iNOS, pro-inflammatory factors, including NO, TNF-[alpha], IL-1[beta], and IL-10. Compared with WEVAL, EEVAL was a more potent inflammatory inhibitor. Both extracts similarly inhibited LPS-induced MAPK (p38) and NF-[kappa]B expression. Our findings indicate that WEVAL and EEVAL have diverse antioxidant and anti-inflammatory effects. WEVAL had a stronger antioxidant and DNA protection activity; contrastingly, EEVAL had a stronger anti-inflammatory ability. The anti-inflammatory activity involves reduced pro-inflammatory cytokines through NF-[kappa]B down-regulation and MAPK inhibition. These results demonstrated that production of WEVAL and EEVAL from VA leaves may provide a safe and efficacious source of pharmaceutical applications, with antioxidant, DNA protective and anti-inflammation activities. |
| doi_str_mv | 10.1371/journal.pone.0235717 |
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We aimed to investigate whether aqueous (WEVAL) and alcoholic (EEVAL) VA extracts exert similar antioxidant, DNA protection and anti-inflammatory effects and attempted to explore the mechanism underlying the anti-inflammatory effects. These results demonstrated that WEVAL had greater polyphenolic and flavonoid contents, as well as a stronger reducing power, DPPH radical scavenging and DNA protective activity. Moreover, both extracts reduced lipopolysaccharide (LPS)-induced expression of COX-II, iNOS, pro-inflammatory factors, including NO, TNF-[alpha], IL-1[beta], and IL-10. Compared with WEVAL, EEVAL was a more potent inflammatory inhibitor. Both extracts similarly inhibited LPS-induced MAPK (p38) and NF-[kappa]B expression. Our findings indicate that WEVAL and EEVAL have diverse antioxidant and anti-inflammatory effects. WEVAL had a stronger antioxidant and DNA protection activity; contrastingly, EEVAL had a stronger anti-inflammatory ability. The anti-inflammatory activity involves reduced pro-inflammatory cytokines through NF-[kappa]B down-regulation and MAPK inhibition. These results demonstrated that production of WEVAL and EEVAL from VA leaves may provide a safe and efficacious source of pharmaceutical applications, with antioxidant, DNA protective and anti-inflammation activities.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0235717</identifier><identifier>PMID: 32658905</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Aluminum ; Anti-inflammatory agents ; Antioxidants ; Antioxidants (Nutrients) ; Biology and Life Sciences ; Biotechnology ; Chemical properties ; Cytokines ; Daisies ; Deoxyribonucleic acid ; DNA ; Flavonoids ; Food science ; Free radicals ; Health aspects ; IL-1β ; Inflammation ; Interleukin 10 ; Kinases ; Lipopolysaccharides ; MAP kinase ; Medical research ; Medicine ; Medicine and Health Sciences ; NF-κB protein ; Nitric-oxide synthase ; Physical Sciences ; Plant extracts ; Polyphenols ; R&D ; Research & development ; Research and Analysis Methods ; Scavenging ; Sodium ; Studies ; Tumor necrosis factor-α ; Vernonia amygdalina</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0235717-e0235717</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Wang et al 2020 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5847-9c995c0654cbc19ec9def4c41a939860d9ef7d874f4fd862eae4213763e710f33</citedby><cites>FETCH-LOGICAL-c5847-9c995c0654cbc19ec9def4c41a939860d9ef7d874f4fd862eae4213763e710f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357738/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357738/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids></links><search><creatorcontrib>Wang, Wei-Te</creatorcontrib><creatorcontrib>Liao, Su-Fen</creatorcontrib><creatorcontrib>Wu, Zih-Ling</creatorcontrib><creatorcontrib>Chang, Chia-Wei</creatorcontrib><creatorcontrib>Wu, Jane-Yii</creatorcontrib><title>Simultaneous study of antioxidant activity, DNA protection and anti-inflammatory effect of Vernonia amygdalina leaves extracts</title><title>PloS one</title><description>Vernonia amygdalina (VA) has been reported to have antioxidant potential; however, its DNA protection and anti-inflammatory properties remain unclear. We aimed to investigate whether aqueous (WEVAL) and alcoholic (EEVAL) VA extracts exert similar antioxidant, DNA protection and anti-inflammatory effects and attempted to explore the mechanism underlying the anti-inflammatory effects. These results demonstrated that WEVAL had greater polyphenolic and flavonoid contents, as well as a stronger reducing power, DPPH radical scavenging and DNA protective activity. Moreover, both extracts reduced lipopolysaccharide (LPS)-induced expression of COX-II, iNOS, pro-inflammatory factors, including NO, TNF-[alpha], IL-1[beta], and IL-10. Compared with WEVAL, EEVAL was a more potent inflammatory inhibitor. Both extracts similarly inhibited LPS-induced MAPK (p38) and NF-[kappa]B expression. Our findings indicate that WEVAL and EEVAL have diverse antioxidant and anti-inflammatory effects. WEVAL had a stronger antioxidant and DNA protection activity; contrastingly, EEVAL had a stronger anti-inflammatory ability. The anti-inflammatory activity involves reduced pro-inflammatory cytokines through NF-[kappa]B down-regulation and MAPK inhibition. These results demonstrated that production of WEVAL and EEVAL from VA leaves may provide a safe and efficacious source of pharmaceutical applications, with antioxidant, DNA protective and anti-inflammation activities.</description><subject>Aluminum</subject><subject>Anti-inflammatory agents</subject><subject>Antioxidants</subject><subject>Antioxidants (Nutrients)</subject><subject>Biology and Life Sciences</subject><subject>Biotechnology</subject><subject>Chemical properties</subject><subject>Cytokines</subject><subject>Daisies</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Flavonoids</subject><subject>Food science</subject><subject>Free radicals</subject><subject>Health aspects</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Kinases</subject><subject>Lipopolysaccharides</subject><subject>MAP kinase</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>NF-κB protein</subject><subject>Nitric-oxide synthase</subject><subject>Physical Sciences</subject><subject>Plant extracts</subject><subject>Polyphenols</subject><subject>R&D</subject><subject>Research & development</subject><subject>Research and Analysis Methods</subject><subject>Scavenging</subject><subject>Sodium</subject><subject>Studies</subject><subject>Tumor necrosis factor-α</subject><subject>Vernonia 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one</jtitle><date>2020-07-13</date><risdate>2020</risdate><volume>15</volume><issue>7</issue><spage>e0235717</spage><epage>e0235717</epage><pages>e0235717-e0235717</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Vernonia amygdalina (VA) has been reported to have antioxidant potential; however, its DNA protection and anti-inflammatory properties remain unclear. We aimed to investigate whether aqueous (WEVAL) and alcoholic (EEVAL) VA extracts exert similar antioxidant, DNA protection and anti-inflammatory effects and attempted to explore the mechanism underlying the anti-inflammatory effects. These results demonstrated that WEVAL had greater polyphenolic and flavonoid contents, as well as a stronger reducing power, DPPH radical scavenging and DNA protective activity. Moreover, both extracts reduced lipopolysaccharide (LPS)-induced expression of COX-II, iNOS, pro-inflammatory factors, including NO, TNF-[alpha], IL-1[beta], and IL-10. Compared with WEVAL, EEVAL was a more potent inflammatory inhibitor. Both extracts similarly inhibited LPS-induced MAPK (p38) and NF-[kappa]B expression. Our findings indicate that WEVAL and EEVAL have diverse antioxidant and anti-inflammatory effects. WEVAL had a stronger antioxidant and DNA protection activity; contrastingly, EEVAL had a stronger anti-inflammatory ability. The anti-inflammatory activity involves reduced pro-inflammatory cytokines through NF-[kappa]B down-regulation and MAPK inhibition. These results demonstrated that production of WEVAL and EEVAL from VA leaves may provide a safe and efficacious source of pharmaceutical applications, with antioxidant, DNA protective and anti-inflammation activities.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32658905</pmid><doi>10.1371/journal.pone.0235717</doi><tpages>e0235717</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aluminum Anti-inflammatory agents Antioxidants Antioxidants (Nutrients) Biology and Life Sciences Biotechnology Chemical properties Cytokines Daisies Deoxyribonucleic acid DNA Flavonoids Food science Free radicals Health aspects IL-1β Inflammation Interleukin 10 Kinases Lipopolysaccharides MAP kinase Medical research Medicine Medicine and Health Sciences NF-κB protein Nitric-oxide synthase Physical Sciences Plant extracts Polyphenols R&D Research & development Research and Analysis Methods Scavenging Sodium Studies Tumor necrosis factor-α Vernonia amygdalina |
| title | Simultaneous study of antioxidant activity, DNA protection and anti-inflammatory effect of Vernonia amygdalina leaves extracts |
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