Characterization of post-edited cells modified in the TFAM gene by CRISPR/Cas9 technology in the bovine model

Gene editing in large animal models for future applications in translational medicine and food production must be deeply investigated for an increase of knowledge. The mitochondrial transcription factor A (TFAM) is a member of the HMGB subfamily that binds to mtDNA promoters. This gene maintains mtD...

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Veröffentlicht in:	PloS one 2020-07, Vol.15 (7), p.e0235856-e0235856
Hauptverfasser:	de Oliveira, Vanessa Cristina, Gomes Mariano Junior, Clésio, Belizário, José Ernesto, Krieger, José Eduardo, Fernandes Bressan, Fabiana, Roballo, Kelly Cristine Santos, Fantinato-Neto, Paulo, Meirelles, Flávio Vieira, Chiaratti, Marcos Roberto, Concordet, Jean-Paul, Ambrósio, Carlos Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetics Animal models Animal sciences Biochemistry, Molecular Biology Biology and life sciences Cell culture Cell viability Cellular Biology Copy number CRISPR Deoxyribonucleic acid DNA Fibroblasts Fluorescence Food Food production Genetic engineering Genetic modification Genetics Genome editing Genomes Growth rate Life Sciences Maintenance Medicine and Health Sciences Membrane potential Membranes Mitochondrial DNA Molecular biology Mutation Proteins Pyruvic acid Research and Analysis Methods Technology Uridine Veterinary medicine Zoology
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