Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity

Three-dimensional liver in vitro systems have recently attracted a lot of attention in drug development. These systems help to gain unprecedented insights into drug-induced liver injury (DILI), as they more closely reproduce liver biology, and as drug effects can be studied in isolated and controlla...

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Veröffentlicht in:PloS one 2020-07, Vol.15 (7), p.e0235745-e0235745
Hauptverfasser: Nudischer, Ramona, Renggli, Kasper, Hierlemann, Andreas, Roth, Adrian B, Bertinetti-Lapatki, Cristina
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Sprache:eng
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