Comparison of efficacy and toxicity of intravitreal melphalan formulations for retinoblastoma

Intravitreal melphalan injections are commonly used in the treatment for intraocular retinoblastoma. This study compares retinal toxicity and ocular survival between two formulations, with and without propylene glycol (Alkeran vs. Evomela, respectively). A retrospective cohort study of retinoblastom...

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Veröffentlicht in:	PloS one 2020-07, Vol.15 (7), p.e0235016-e0235016
Hauptverfasser:	Hsieh, Terry, Liao, Albert, Francis, Jasmine H, Lavery, Jessica A, Mauguen, Audrey, Brodie, Scott E, Abramson, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohols Biology and Life Sciences Cancer Chemotherapy Cost benefit analysis Drug dosages Drug therapy Electroretinograms Epidemiology Ethanol Eye Eye (anatomy) Medicine and Health Sciences Melphalan Metabolites Multivariate analysis Oncology Patient outcomes Patients Physical Sciences Propylene Propylene glycol Retina Retinoblastoma Statistical models Survival Toxicity Tumors
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