A variety of bacterial aetiologies in the lower respiratory tract at patients with endobronchial tuberculosis
Recently, our understanding of the elusive bacterial communities in the lower respiratory tract and their role in chronic lung disease has increased significantly. However, little is known about the respiratory microorganisms in patients with endobronchial tuberculosis (EBTB), which is a chronic inf...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-06, Vol.15 (6), p.e0234558-e0234558 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0234558 |
|---|---|
| container_issue | 6 |
| container_start_page | e0234558 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Kim, Sae Byol Lee, Won-Yeon Lee, Ji-Ho Lee, Seok Jeong Lee, Myoung Kyu Kim, Sang-Ha Uh, Young Jung, Soon-Hee Shin, Beomsu |
| description | Recently, our understanding of the elusive bacterial communities in the lower respiratory tract and their role in chronic lung disease has increased significantly. However, little is known about the respiratory microorganisms in patients with endobronchial tuberculosis (EBTB), which is a chronic inflammatory disease characterized by destruction of the tracheobronchial tree due to Mycobacterium tuberculosis (MTB) infection. We retrospectively reviewed data for histopathologically and microbiologically confirmed EBTB patients diagnosed at a tertiary referral hospital in South Korea between January 2013 and January 2019. Bacterial cultures were performed on bronchial washing from these patients at the time of EBTB diagnosis. A total of 216 patients with EBTB were included in the study. The median age was 73 years and 142 (65.7%) patients were female. Bacteria were detected in 42 (19.4%) patients. Additionally, bacterial co-infection was present in 6 (2.8%) patients. Apart from MTB, the most common microorganisms identified were Staphylococcus aureus (n = 14, 33.3%) followed by Klebsiella species (n = 12, 28.6%; 10 Klebsiella pneumoniae, 2 Klebsiella oxytoca), Streptococcus species (n = 5, 11.9%), Enterobacter species (n = 4, 9.5%), and Pseudomonas aeruginosa (n = 3, 7.1%). A variety of microorganisms were isolated from the bronchial washing indicating that changes in microorganism composition occur in the airways of patients with EBTB. Further studies are needed to investigate the clinical significance of this finding. |
| doi_str_mv | 10.1371/journal.pone.0234558 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2417366651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A627639830</galeid><doaj_id>oai_doaj_org_article_e98d1663e29a46efb45c07918f5f1580</doaj_id><sourcerecordid>A627639830</sourcerecordid><originalsourceid>FETCH-LOGICAL-c669t-7d8684c5e63611243db07325d9259f3ef71c0192a584babcf0880538263c7d943</originalsourceid><addsrcrecordid>eNqNk12L3CAUhkNp6X60_6BQoVDai5lGTYzeLAxLPwYWFvp1K8acTBycOFWz2_n3a3bSsil7UbxQ9PE95z16suwVzpeYVvjD1g2-V3a5dz0sc0KLsuRPslMsKFkwktOnD9Yn2VkI2zwvKWfseXZCSckLXpLTbLdCN8obiAfkWlQrHcEbZZGCaJx1GwMBmR7FDpB1t-CRh7A3XkXnDyj6xCMV0V5FA30M6NbEDkHfuNq7XnejUhxq8HqwLpjwInvWKhvg5TSfZz8-ffx--WVxdf15fbm6WmjGRFxUDWe80CUwyjAmBW3qvEo5N4KUoqXQVljnWBCVXNSq1m3O-eiNMKqrRhT0PHt91N2nsHKqVJCkwBVljJU4Eesj0Ti1lXtvdsofpFNG3m84v5HKR6MtSBC8wYxRIEIVDNq6KHVeCczbssUlz5PWxRRtqHfQ6FQJr-xMdH7Sm05u3I2sKGakqpLAu0nAu18DhCh3JmiwVvXghvu8OSZYFKOzN_-gj7ubqI1KBkzfuvGpRlG5ShEZFZyOeS8fodJoYGd0-latSfuzC-9nFxIT4XfcqCEEuf729f_Z659z9u0DtgNlYxecHdIX7MMcLI6g9i4ED-3fIuNcjl3xpxpy7Ao5dQW9A7rr_aY</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2417366651</pqid></control><display><type>article</type><title>A variety of bacterial aetiologies in the lower respiratory tract at patients with endobronchial tuberculosis</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Kim, Sae Byol ; Lee, Won-Yeon ; Lee, Ji-Ho ; Lee, Seok Jeong ; Lee, Myoung Kyu ; Kim, Sang-Ha ; Uh, Young ; Jung, Soon-Hee ; Shin, Beomsu</creator><contributor>Quinn, Frederick</contributor><creatorcontrib>Kim, Sae Byol ; Lee, Won-Yeon ; Lee, Ji-Ho ; Lee, Seok Jeong ; Lee, Myoung Kyu ; Kim, Sang-Ha ; Uh, Young ; Jung, Soon-Hee ; Shin, Beomsu ; Quinn, Frederick</creatorcontrib><description>Recently, our understanding of the elusive bacterial communities in the lower respiratory tract and their role in chronic lung disease has increased significantly. However, little is known about the respiratory microorganisms in patients with endobronchial tuberculosis (EBTB), which is a chronic inflammatory disease characterized by destruction of the tracheobronchial tree due to Mycobacterium tuberculosis (MTB) infection. We retrospectively reviewed data for histopathologically and microbiologically confirmed EBTB patients diagnosed at a tertiary referral hospital in South Korea between January 2013 and January 2019. Bacterial cultures were performed on bronchial washing from these patients at the time of EBTB diagnosis. A total of 216 patients with EBTB were included in the study. The median age was 73 years and 142 (65.7%) patients were female. Bacteria were detected in 42 (19.4%) patients. Additionally, bacterial co-infection was present in 6 (2.8%) patients. Apart from MTB, the most common microorganisms identified were Staphylococcus aureus (n = 14, 33.3%) followed by Klebsiella species (n = 12, 28.6%; 10 Klebsiella pneumoniae, 2 Klebsiella oxytoca), Streptococcus species (n = 5, 11.9%), Enterobacter species (n = 4, 9.5%), and Pseudomonas aeruginosa (n = 3, 7.1%). A variety of microorganisms were isolated from the bronchial washing indicating that changes in microorganism composition occur in the airways of patients with EBTB. Further studies are needed to investigate the clinical significance of this finding.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0234558</identifier><identifier>PMID: 32584852</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Bacteria ; Biology and Life Sciences ; Biopsy ; Bronchial diseases ; Bronchoscopy ; Causes of ; Chronic obstructive pulmonary disease ; Concurrent infection ; Development and progression ; Diagnosis ; Hospitals ; Identification and classification ; Inflammation ; Inflammatory diseases ; Internal medicine ; Kim, Won ; Klebsiella ; Lung diseases ; Medical schools ; Medicine ; Medicine and Health Sciences ; Microorganisms ; Pathogenesis ; Pathogenic bacteria ; Patients ; Pseudomonas aeruginosa ; Respiratory tract ; Species ; Statistical analysis ; Streptococcus infections ; Tuberculosis ; Ulcers ; Washing</subject><ispartof>PloS one, 2020-06, Vol.15 (6), p.e0234558-e0234558</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Kim et al 2020 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-7d8684c5e63611243db07325d9259f3ef71c0192a584babcf0880538263c7d943</citedby><cites>FETCH-LOGICAL-c669t-7d8684c5e63611243db07325d9259f3ef71c0192a584babcf0880538263c7d943</cites><orcidid>0000-0003-3565-3426 ; 0000-0002-8449-0195</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316277/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316277/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids></links><search><contributor>Quinn, Frederick</contributor><creatorcontrib>Kim, Sae Byol</creatorcontrib><creatorcontrib>Lee, Won-Yeon</creatorcontrib><creatorcontrib>Lee, Ji-Ho</creatorcontrib><creatorcontrib>Lee, Seok Jeong</creatorcontrib><creatorcontrib>Lee, Myoung Kyu</creatorcontrib><creatorcontrib>Kim, Sang-Ha</creatorcontrib><creatorcontrib>Uh, Young</creatorcontrib><creatorcontrib>Jung, Soon-Hee</creatorcontrib><creatorcontrib>Shin, Beomsu</creatorcontrib><title>A variety of bacterial aetiologies in the lower respiratory tract at patients with endobronchial tuberculosis</title><title>PloS one</title><description>Recently, our understanding of the elusive bacterial communities in the lower respiratory tract and their role in chronic lung disease has increased significantly. However, little is known about the respiratory microorganisms in patients with endobronchial tuberculosis (EBTB), which is a chronic inflammatory disease characterized by destruction of the tracheobronchial tree due to Mycobacterium tuberculosis (MTB) infection. We retrospectively reviewed data for histopathologically and microbiologically confirmed EBTB patients diagnosed at a tertiary referral hospital in South Korea between January 2013 and January 2019. Bacterial cultures were performed on bronchial washing from these patients at the time of EBTB diagnosis. A total of 216 patients with EBTB were included in the study. The median age was 73 years and 142 (65.7%) patients were female. Bacteria were detected in 42 (19.4%) patients. Additionally, bacterial co-infection was present in 6 (2.8%) patients. Apart from MTB, the most common microorganisms identified were Staphylococcus aureus (n = 14, 33.3%) followed by Klebsiella species (n = 12, 28.6%; 10 Klebsiella pneumoniae, 2 Klebsiella oxytoca), Streptococcus species (n = 5, 11.9%), Enterobacter species (n = 4, 9.5%), and Pseudomonas aeruginosa (n = 3, 7.1%). A variety of microorganisms were isolated from the bronchial washing indicating that changes in microorganism composition occur in the airways of patients with EBTB. Further studies are needed to investigate the clinical significance of this finding.</description><subject>Bacteria</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Bronchial diseases</subject><subject>Bronchoscopy</subject><subject>Causes of</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Concurrent infection</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Hospitals</subject><subject>Identification and classification</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Internal medicine</subject><subject>Kim, Won</subject><subject>Klebsiella</subject><subject>Lung diseases</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Microorganisms</subject><subject>Pathogenesis</subject><subject>Pathogenic bacteria</subject><subject>Patients</subject><subject>Pseudomonas aeruginosa</subject><subject>Respiratory tract</subject><subject>Species</subject><subject>Statistical analysis</subject><subject>Streptococcus infections</subject><subject>Tuberculosis</subject><subject>Ulcers</subject><subject>Washing</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L3CAUhkNp6X60_6BQoVDai5lGTYzeLAxLPwYWFvp1K8acTBycOFWz2_n3a3bSsil7UbxQ9PE95z16suwVzpeYVvjD1g2-V3a5dz0sc0KLsuRPslMsKFkwktOnD9Yn2VkI2zwvKWfseXZCSckLXpLTbLdCN8obiAfkWlQrHcEbZZGCaJx1GwMBmR7FDpB1t-CRh7A3XkXnDyj6xCMV0V5FA30M6NbEDkHfuNq7XnejUhxq8HqwLpjwInvWKhvg5TSfZz8-ffx--WVxdf15fbm6WmjGRFxUDWe80CUwyjAmBW3qvEo5N4KUoqXQVljnWBCVXNSq1m3O-eiNMKqrRhT0PHt91N2nsHKqVJCkwBVljJU4Eesj0Ti1lXtvdsofpFNG3m84v5HKR6MtSBC8wYxRIEIVDNq6KHVeCczbssUlz5PWxRRtqHfQ6FQJr-xMdH7Sm05u3I2sKGakqpLAu0nAu18DhCh3JmiwVvXghvu8OSZYFKOzN_-gj7ubqI1KBkzfuvGpRlG5ShEZFZyOeS8fodJoYGd0-latSfuzC-9nFxIT4XfcqCEEuf729f_Z659z9u0DtgNlYxecHdIX7MMcLI6g9i4ED-3fIuNcjl3xpxpy7Ao5dQW9A7rr_aY</recordid><startdate>20200625</startdate><enddate>20200625</enddate><creator>Kim, Sae Byol</creator><creator>Lee, Won-Yeon</creator><creator>Lee, Ji-Ho</creator><creator>Lee, Seok Jeong</creator><creator>Lee, Myoung Kyu</creator><creator>Kim, Sang-Ha</creator><creator>Uh, Young</creator><creator>Jung, Soon-Hee</creator><creator>Shin, Beomsu</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3565-3426</orcidid><orcidid>https://orcid.org/0000-0002-8449-0195</orcidid></search><sort><creationdate>20200625</creationdate><title>A variety of bacterial aetiologies in the lower respiratory tract at patients with endobronchial tuberculosis</title><author>Kim, Sae Byol ; Lee, Won-Yeon ; Lee, Ji-Ho ; Lee, Seok Jeong ; Lee, Myoung Kyu ; Kim, Sang-Ha ; Uh, Young ; Jung, Soon-Hee ; Shin, Beomsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-7d8684c5e63611243db07325d9259f3ef71c0192a584babcf0880538263c7d943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bacteria</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Bronchial diseases</topic><topic>Bronchoscopy</topic><topic>Causes of</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Concurrent infection</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Hospitals</topic><topic>Identification and classification</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Internal medicine</topic><topic>Kim, Won</topic><topic>Klebsiella</topic><topic>Lung diseases</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Microorganisms</topic><topic>Pathogenesis</topic><topic>Pathogenic bacteria</topic><topic>Patients</topic><topic>Pseudomonas aeruginosa</topic><topic>Respiratory tract</topic><topic>Species</topic><topic>Statistical analysis</topic><topic>Streptococcus infections</topic><topic>Tuberculosis</topic><topic>Ulcers</topic><topic>Washing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sae Byol</creatorcontrib><creatorcontrib>Lee, Won-Yeon</creatorcontrib><creatorcontrib>Lee, Ji-Ho</creatorcontrib><creatorcontrib>Lee, Seok Jeong</creatorcontrib><creatorcontrib>Lee, Myoung Kyu</creatorcontrib><creatorcontrib>Kim, Sang-Ha</creatorcontrib><creatorcontrib>Uh, Young</creatorcontrib><creatorcontrib>Jung, Soon-Hee</creatorcontrib><creatorcontrib>Shin, Beomsu</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sae Byol</au><au>Lee, Won-Yeon</au><au>Lee, Ji-Ho</au><au>Lee, Seok Jeong</au><au>Lee, Myoung Kyu</au><au>Kim, Sang-Ha</au><au>Uh, Young</au><au>Jung, Soon-Hee</au><au>Shin, Beomsu</au><au>Quinn, Frederick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A variety of bacterial aetiologies in the lower respiratory tract at patients with endobronchial tuberculosis</atitle><jtitle>PloS one</jtitle><date>2020-06-25</date><risdate>2020</risdate><volume>15</volume><issue>6</issue><spage>e0234558</spage><epage>e0234558</epage><pages>e0234558-e0234558</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Recently, our understanding of the elusive bacterial communities in the lower respiratory tract and their role in chronic lung disease has increased significantly. However, little is known about the respiratory microorganisms in patients with endobronchial tuberculosis (EBTB), which is a chronic inflammatory disease characterized by destruction of the tracheobronchial tree due to Mycobacterium tuberculosis (MTB) infection. We retrospectively reviewed data for histopathologically and microbiologically confirmed EBTB patients diagnosed at a tertiary referral hospital in South Korea between January 2013 and January 2019. Bacterial cultures were performed on bronchial washing from these patients at the time of EBTB diagnosis. A total of 216 patients with EBTB were included in the study. The median age was 73 years and 142 (65.7%) patients were female. Bacteria were detected in 42 (19.4%) patients. Additionally, bacterial co-infection was present in 6 (2.8%) patients. Apart from MTB, the most common microorganisms identified were Staphylococcus aureus (n = 14, 33.3%) followed by Klebsiella species (n = 12, 28.6%; 10 Klebsiella pneumoniae, 2 Klebsiella oxytoca), Streptococcus species (n = 5, 11.9%), Enterobacter species (n = 4, 9.5%), and Pseudomonas aeruginosa (n = 3, 7.1%). A variety of microorganisms were isolated from the bronchial washing indicating that changes in microorganism composition occur in the airways of patients with EBTB. Further studies are needed to investigate the clinical significance of this finding.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32584852</pmid><doi>10.1371/journal.pone.0234558</doi><tpages>e0234558</tpages><orcidid>https://orcid.org/0000-0003-3565-3426</orcidid><orcidid>https://orcid.org/0000-0002-8449-0195</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-06, Vol.15 (6), p.e0234558-e0234558 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2417366651 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Bacteria Biology and Life Sciences Biopsy Bronchial diseases Bronchoscopy Causes of Chronic obstructive pulmonary disease Concurrent infection Development and progression Diagnosis Hospitals Identification and classification Inflammation Inflammatory diseases Internal medicine Kim, Won Klebsiella Lung diseases Medical schools Medicine Medicine and Health Sciences Microorganisms Pathogenesis Pathogenic bacteria Patients Pseudomonas aeruginosa Respiratory tract Species Statistical analysis Streptococcus infections Tuberculosis Ulcers Washing |
| title | A variety of bacterial aetiologies in the lower respiratory tract at patients with endobronchial tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T04%3A15%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20variety%20of%20bacterial%20aetiologies%20in%20the%20lower%20respiratory%20tract%20at%20patients%20with%20endobronchial%20tuberculosis&rft.jtitle=PloS%20one&rft.au=Kim,%20Sae%20Byol&rft.date=2020-06-25&rft.volume=15&rft.issue=6&rft.spage=e0234558&rft.epage=e0234558&rft.pages=e0234558-e0234558&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0234558&rft_dat=%3Cgale_plos_%3EA627639830%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2417366651&rft_id=info:pmid/32584852&rft_galeid=A627639830&rft_doaj_id=oai_doaj_org_article_e98d1663e29a46efb45c07918f5f1580&rfr_iscdi=true |