Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study
Despite remarkable progress in the reduction of death in under-five children, neonatal mortality has shown little or no concomitant reduction globally. It is also one of the most common causes of neonatal death in Ethiopia. Little is known on predictors of neonatal sepsis. Risk based screening and c...
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| creator | Akalu, Tadesse Yirga Gebremichael, Bereket Desta, Kalkidan Wondwossen Aynalem, Yared Asmare Shiferaw, Wondimeneh Shibabaw Alamneh, Yoseph Merkeb |
| description | Despite remarkable progress in the reduction of death in under-five children, neonatal mortality has shown little or no concomitant reduction globally. It is also one of the most common causes of neonatal death in Ethiopia. Little is known on predictors of neonatal sepsis. Risk based screening and commencement of treatment appreciably reduces neonatal death and illness. Therefore, the main aim of this study was to identify predictors of neonatal sepsis in public referral hospitals of Northwest Ethiopia.
Institutional based unmatched case-control study was conducted among a total of 231 neonates in Debre Markos and Felege Hiwot referral hospitals from March 2018- April 2018. Neonates who fulfill the preseted criteria for sepsis were considered as cases and neonates diagnosed with other medical reasons except sepsis were controls. For each case, two consecutive controls were selected by simple random sampling method. Data were collected using structured pretested questionnaire through a face to face interview with index mothers and by reviewing neonatal record using checklist. The collected data were entered into Epi data version 3.1 and exported to STATA/ SE software version 14. Binary and multivariable logistic regression analyses were employed. Statistical significance was declared at P |
| doi_str_mv | 10.1371/journal.pone.0234472 |
| format | Article |
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Institutional based unmatched case-control study was conducted among a total of 231 neonates in Debre Markos and Felege Hiwot referral hospitals from March 2018- April 2018. Neonates who fulfill the preseted criteria for sepsis were considered as cases and neonates diagnosed with other medical reasons except sepsis were controls. For each case, two consecutive controls were selected by simple random sampling method. Data were collected using structured pretested questionnaire through a face to face interview with index mothers and by reviewing neonatal record using checklist. The collected data were entered into Epi data version 3.1 and exported to STATA/ SE software version 14. Binary and multivariable logistic regression analyses were employed. Statistical significance was declared at P<0.05.
Multivariable logistic regression analysis showed that, duration of rupture of membrane ≥ 18hours was significantly associated with sepsis (AOR = 10.4, 95%CI = 2.3-46.5). The other independent predictors of neonatal sepsis were number of maternal antenatal care service ≤3 (AOR = 4.4, 95%CI = 1.7-11.5), meconium stained amniotic fluid (AOR = 3.9, 95%CI = 1.5-9.8), urinary tract infection during pregnancy (AOR = 10.8, 95% CI = 3.4-33.9), intranatal fever (AOR = 3.2, 95% CI = 1.1-9.5), first minute APGAR score <7 (AOR = 3.2, 95% CI = 1.3-7.7), resuscitation at birth (AOR = 5.4, 95% CI = 1.9-15.5), nasogastric tube insertion (AOR = 3.7, 95% CI = 1.4-10.2).
Neonatal invasive procedures, ANC follow up during pregnancy, different conditions during birth like meconium stained amniotic fluid, low APGAR score and resuscitation at birth were the independent predictors of neonatal sepsis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0234472</identifier><identifier>PMID: 32579580</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Amniotic Fluid ; Apgar Score ; Biology and Life Sciences ; Birth ; Births ; Case-Control Studies ; Childbirth & labor ; Data collection ; Death ; Ethiopia ; Female ; Fever ; Health risks ; Hospitals ; Hospitals, Public ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Intensive care ; Meconium ; Medical referrals ; Medicine and Health Sciences ; Methods ; Mortality ; Mothers ; Neonatal diseases ; Neonatal screening ; Neonatal Sepsis - epidemiology ; Neonates ; Newborn babies ; Parturition ; Pediatric research ; Perinatal Death - etiology ; Pregnancy ; Prenatal Care ; Random sampling ; Reduction ; Regression analysis ; Resuscitation ; Risk factors ; Sampling methods ; Sepsis ; Statistical analysis ; Statistical sampling ; Statistics ; Urinary tract ; Urinary tract diseases ; Urinary tract infections ; Urinary Tract Infections - complications ; Urogenital system ; Vagina ; Young Adult</subject><ispartof>PloS one, 2020-06, Vol.15 (6), p.e0234472-e0234472</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Akalu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Akalu et al 2020 Akalu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-16d5e3e512e07215fd7695fee85355876be3dd4b9f2b4c2d019e11671e8749ac3</citedby><cites>FETCH-LOGICAL-c692t-16d5e3e512e07215fd7695fee85355876be3dd4b9f2b4c2d019e11671e8749ac3</cites><orcidid>0000-0002-5475-6183</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314009/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314009/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32579580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akalu, Tadesse Yirga</creatorcontrib><creatorcontrib>Gebremichael, Bereket</creatorcontrib><creatorcontrib>Desta, Kalkidan Wondwossen</creatorcontrib><creatorcontrib>Aynalem, Yared Asmare</creatorcontrib><creatorcontrib>Shiferaw, Wondimeneh Shibabaw</creatorcontrib><creatorcontrib>Alamneh, Yoseph Merkeb</creatorcontrib><title>Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Despite remarkable progress in the reduction of death in under-five children, neonatal mortality has shown little or no concomitant reduction globally. It is also one of the most common causes of neonatal death in Ethiopia. Little is known on predictors of neonatal sepsis. Risk based screening and commencement of treatment appreciably reduces neonatal death and illness. Therefore, the main aim of this study was to identify predictors of neonatal sepsis in public referral hospitals of Northwest Ethiopia.
Institutional based unmatched case-control study was conducted among a total of 231 neonates in Debre Markos and Felege Hiwot referral hospitals from March 2018- April 2018. Neonates who fulfill the preseted criteria for sepsis were considered as cases and neonates diagnosed with other medical reasons except sepsis were controls. For each case, two consecutive controls were selected by simple random sampling method. Data were collected using structured pretested questionnaire through a face to face interview with index mothers and by reviewing neonatal record using checklist. The collected data were entered into Epi data version 3.1 and exported to STATA/ SE software version 14. Binary and multivariable logistic regression analyses were employed. Statistical significance was declared at P<0.05.
Multivariable logistic regression analysis showed that, duration of rupture of membrane ≥ 18hours was significantly associated with sepsis (AOR = 10.4, 95%CI = 2.3-46.5). The other independent predictors of neonatal sepsis were number of maternal antenatal care service ≤3 (AOR = 4.4, 95%CI = 1.7-11.5), meconium stained amniotic fluid (AOR = 3.9, 95%CI = 1.5-9.8), urinary tract infection during pregnancy (AOR = 10.8, 95% CI = 3.4-33.9), intranatal fever (AOR = 3.2, 95% CI = 1.1-9.5), first minute APGAR score <7 (AOR = 3.2, 95% CI = 1.3-7.7), resuscitation at birth (AOR = 5.4, 95% CI = 1.9-15.5), nasogastric tube insertion (AOR = 3.7, 95% CI = 1.4-10.2).
Neonatal invasive procedures, ANC follow up during pregnancy, different conditions during birth like meconium stained amniotic fluid, low APGAR score and resuscitation at birth were the independent predictors of neonatal sepsis.</description><subject>Adult</subject><subject>Amniotic Fluid</subject><subject>Apgar Score</subject><subject>Biology and Life Sciences</subject><subject>Birth</subject><subject>Births</subject><subject>Case-Control Studies</subject><subject>Childbirth & labor</subject><subject>Data collection</subject><subject>Death</subject><subject>Ethiopia</subject><subject>Female</subject><subject>Fever</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Hospitals, Public</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Mortality</subject><subject>Infant, Newborn</subject><subject>Intensive care</subject><subject>Meconium</subject><subject>Medical referrals</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Mortality</subject><subject>Mothers</subject><subject>Neonatal diseases</subject><subject>Neonatal screening</subject><subject>Neonatal Sepsis - epidemiology</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Parturition</subject><subject>Pediatric research</subject><subject>Perinatal Death - etiology</subject><subject>Pregnancy</subject><subject>Prenatal Care</subject><subject>Random sampling</subject><subject>Reduction</subject><subject>Regression analysis</subject><subject>Resuscitation</subject><subject>Risk factors</subject><subject>Sampling methods</subject><subject>Sepsis</subject><subject>Statistical analysis</subject><subject>Statistical sampling</subject><subject>Statistics</subject><subject>Urinary tract</subject><subject>Urinary tract diseases</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - complications</subject><subject>Urogenital 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progress in the reduction of death in under-five children, neonatal mortality has shown little or no concomitant reduction globally. It is also one of the most common causes of neonatal death in Ethiopia. Little is known on predictors of neonatal sepsis. Risk based screening and commencement of treatment appreciably reduces neonatal death and illness. Therefore, the main aim of this study was to identify predictors of neonatal sepsis in public referral hospitals of Northwest Ethiopia.
Institutional based unmatched case-control study was conducted among a total of 231 neonates in Debre Markos and Felege Hiwot referral hospitals from March 2018- April 2018. Neonates who fulfill the preseted criteria for sepsis were considered as cases and neonates diagnosed with other medical reasons except sepsis were controls. For each case, two consecutive controls were selected by simple random sampling method. Data were collected using structured pretested questionnaire through a face to face interview with index mothers and by reviewing neonatal record using checklist. The collected data were entered into Epi data version 3.1 and exported to STATA/ SE software version 14. Binary and multivariable logistic regression analyses were employed. Statistical significance was declared at P<0.05.
Multivariable logistic regression analysis showed that, duration of rupture of membrane ≥ 18hours was significantly associated with sepsis (AOR = 10.4, 95%CI = 2.3-46.5). The other independent predictors of neonatal sepsis were number of maternal antenatal care service ≤3 (AOR = 4.4, 95%CI = 1.7-11.5), meconium stained amniotic fluid (AOR = 3.9, 95%CI = 1.5-9.8), urinary tract infection during pregnancy (AOR = 10.8, 95% CI = 3.4-33.9), intranatal fever (AOR = 3.2, 95% CI = 1.1-9.5), first minute APGAR score <7 (AOR = 3.2, 95% CI = 1.3-7.7), resuscitation at birth (AOR = 5.4, 95% CI = 1.9-15.5), nasogastric tube insertion (AOR = 3.7, 95% CI = 1.4-10.2).
Neonatal invasive procedures, ANC follow up during pregnancy, different conditions during birth like meconium stained amniotic fluid, low APGAR score and resuscitation at birth were the independent predictors of neonatal sepsis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32579580</pmid><doi>10.1371/journal.pone.0234472</doi><tpages>e0234472</tpages><orcidid>https://orcid.org/0000-0002-5475-6183</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_2417000207 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Amniotic Fluid Apgar Score Biology and Life Sciences Birth Births Case-Control Studies Childbirth & labor Data collection Death Ethiopia Female Fever Health risks Hospitals Hospitals, Public Humans Infant Infant Mortality Infant, Newborn Intensive care Meconium Medical referrals Medicine and Health Sciences Methods Mortality Mothers Neonatal diseases Neonatal screening Neonatal Sepsis - epidemiology Neonates Newborn babies Parturition Pediatric research Perinatal Death - etiology Pregnancy Prenatal Care Random sampling Reduction Regression analysis Resuscitation Risk factors Sampling methods Sepsis Statistical analysis Statistical sampling Statistics Urinary tract Urinary tract diseases Urinary tract infections Urinary Tract Infections - complications Urogenital system Vagina Young Adult |
| title | Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T18%3A29%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predictors%20of%20neonatal%20sepsis%20in%20public%20referral%20hospitals,%20Northwest%20Ethiopia:%20A%20case%20control%20study&rft.jtitle=PloS%20one&rft.au=Akalu,%20Tadesse%20Yirga&rft.date=2020-06-24&rft.volume=15&rft.issue=6&rft.spage=e0234472&rft.epage=e0234472&rft.pages=e0234472-e0234472&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0234472&rft_dat=%3Cgale_plos_%3EA627563333%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2417000207&rft_id=info:pmid/32579580&rft_galeid=A627563333&rft_doaj_id=oai_doaj_org_article_ec252b0e84bb4a28ba5e59f4f4ada1d6&rfr_iscdi=true |