Early detection of skeletal muscle bioenergetic deficit by magnetic resonance spectroscopy in cigarette smoke-exposed mice

Skeletal muscle dysfunction is a common complication and an important prognostic factor in patients with chronic obstructive pulmonary disease (COPD). It is associated with intrinsic muscular abnormalities of the lower extremities, but it is not known whether there is an easy way to predict its pres...

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Veröffentlicht in:	PloS one 2020-06, Vol.15 (6), p.e0234606
Hauptverfasser:	Pérez-Rial, Sandra, Barreiro, Esther, Fernández-Aceñero, María Jesús, Fernández-Valle, María Encarnación, González-Mangado, Nicolás, Peces-Barba, Germán
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adenosine triphosphate Adenosine Triphosphate - biosynthesis Adenosine Triphosphate - deficiency Animals ATP Bioenergetics Biology and Life Sciences Biomedical research Body weight Body weight gain Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Complications and side effects Cytochrome Cytochrome-c oxidase Cytochromes Development and progression Diagnosis Disease Emphysema Energy Metabolism Enzymatic activity Enzyme activity Enzymes Exposure Extremities Gastrocnemius muscle Health aspects Homeostasis Hypotheses Laboratories Lung diseases Lung Diseases - diagnosis Lungs Magnetic resonance Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Medical research Medicine and Health Sciences Metabolism Mice Mitochondria Mitochondria - metabolism Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Muscles Muscular diseases Musculoskeletal system Nicotiana - adverse effects Nuclear magnetic resonance spectroscopy Obstructive lung disease Phosphorylation Pulmonary Disease, Chronic Obstructive - diagnosis Research parks Resonance Skeletal muscle Smoke Smoke - adverse effects Smoking Social Sciences Spectroscopy Spectrum analysis Synthesis Therapeutic applications
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