Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use
Methadone is a synthetic opioid used as maintenance treatment for patients addicted to heroin. Skin irritation is one of the adverse events caused by opioid use. 344 methadone maintenance treatment (MMT) patients were recruited with records and measurements on methadone dose, plasma methadone concen...
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| Veröffentlicht in: | PloS one 2020-06, Vol.15 (6), p.e0234549 |
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| creator | Fang, Chiu-Ping Liu, Tung-Hsia Chung, Ren-Hua Tsou, Hsiao-Hui Kuo, Hsiang-Wei Wang, Sheng-Chang Liu, Chia-Chen Liu, Shu Chih Chen, Andrew C H Liu, Yu-Li |
| description | Methadone is a synthetic opioid used as maintenance treatment for patients addicted to heroin. Skin irritation is one of the adverse events caused by opioid use. 344 methadone maintenance treatment (MMT) patients were recruited with records and measurements on methadone dose, plasma methadone concentrations, and treatment emergent symptom scales (TESS). 15 patients reported with skin irritation. Five SNPs located within the NECTIN4 genetic region were genotyped. The NECTIN4 gene within the adherens junction interaction pathway was associated with methadone dose in pathway-based genome wide association analyses (P = 0.0008). Three highly-linked SNPs, rs11265549, rs3820097, and rs4656978, were significantly associated with methadone dose (P = 0.0003), plasma concentrations of R,S-methadone (P = 0.0004) and TNF-α (P = 0.010) in all 344 MMT patients, and with self-report skin irritation symptom scores (P = 0.010) in the 15 MMT patients who reported with skin irritation. To identify the possible roles of plasma level of Nectin-4 in the responses to MMT and opioid use, additional age- and gender-matched 51 controls and 83 methadone-free abstinent former heroin users were recruited. Plasma level of Nectin-4 was the highest in MMT patients among the three groups. The results suggest involvement of genetic variants on NECTIN4 in methadone dose. Plasma Nectin-4 level is likely an indicator for continued use of opioids. |
| doi_str_mv | 10.1371/journal.pone.0234549 |
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Skin irritation is one of the adverse events caused by opioid use. 344 methadone maintenance treatment (MMT) patients were recruited with records and measurements on methadone dose, plasma methadone concentrations, and treatment emergent symptom scales (TESS). 15 patients reported with skin irritation. Five SNPs located within the NECTIN4 genetic region were genotyped. The NECTIN4 gene within the adherens junction interaction pathway was associated with methadone dose in pathway-based genome wide association analyses (P = 0.0008). Three highly-linked SNPs, rs11265549, rs3820097, and rs4656978, were significantly associated with methadone dose (P = 0.0003), plasma concentrations of R,S-methadone (P = 0.0004) and TNF-α (P = 0.010) in all 344 MMT patients, and with self-report skin irritation symptom scores (P = 0.010) in the 15 MMT patients who reported with skin irritation. To identify the possible roles of plasma level of Nectin-4 in the responses to MMT and opioid use, additional age- and gender-matched 51 controls and 83 methadone-free abstinent former heroin users were recruited. Plasma level of Nectin-4 was the highest in MMT patients among the three groups. The results suggest involvement of genetic variants on NECTIN4 in methadone dose. Plasma Nectin-4 level is likely an indicator for continued use of opioids.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0234549</identifier><identifier>PMID: 32555608</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - adverse effects ; Antibodies ; Bioinformatics ; Biology and Life Sciences ; Cell adhesion & migration ; Cell Adhesion Molecules - blood ; Cell Adhesion Molecules - genetics ; Clinical trials ; Complications and side effects ; Cytokines ; Dose-response relationship ; Drug abuse ; Drug dosages ; Drug metabolism ; Enzymes ; Female ; Gene expression ; Genetic aspects ; Genetic diversity ; Genetic Predisposition to Disease ; Genetic variance ; Genetic variation ; Genome-Wide Association Study ; Genomes ; Health aspects ; Health sciences ; Heroin ; Heroin Dependence - blood ; Heroin Dependence - drug therapy ; Heroin Dependence - genetics ; Heroin Dependence - pathology ; Humans ; Irritation ; Maintenance ; Male ; Medical records ; Medical research ; Medicine and Health Sciences ; Methadone ; Methadone - administration & dosage ; Methadone - adverse effects ; Methadone - blood ; Narcotics ; Nectin ; Opiate Substitution Treatment - methods ; Opioid-Related Disorders - blood ; Opioid-Related Disorders - drug therapy ; Opioid-Related Disorders - genetics ; Opioid-Related Disorders - pathology ; Opioids ; Plasma ; Single-nucleotide polymorphism ; Skin ; Social Sciences ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>PloS one, 2020-06, Vol.15 (6), p.e0234549</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Fang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Fang et al 2020 Fang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-496250e217e3340bee1b1222928764ea5c028104581ed7fb4b33082454c996b83</citedby><cites>FETCH-LOGICAL-c692t-496250e217e3340bee1b1222928764ea5c028104581ed7fb4b33082454c996b83</cites><orcidid>0000-0001-7519-2965</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302666/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302666/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32555608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ikeda, Kazutaka</contributor><creatorcontrib>Fang, Chiu-Ping</creatorcontrib><creatorcontrib>Liu, Tung-Hsia</creatorcontrib><creatorcontrib>Chung, Ren-Hua</creatorcontrib><creatorcontrib>Tsou, Hsiao-Hui</creatorcontrib><creatorcontrib>Kuo, Hsiang-Wei</creatorcontrib><creatorcontrib>Wang, Sheng-Chang</creatorcontrib><creatorcontrib>Liu, Chia-Chen</creatorcontrib><creatorcontrib>Liu, Shu Chih</creatorcontrib><creatorcontrib>Chen, Andrew C H</creatorcontrib><creatorcontrib>Liu, Yu-Li</creatorcontrib><title>Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Methadone is a synthetic opioid used as maintenance treatment for patients addicted to heroin. Skin irritation is one of the adverse events caused by opioid use. 344 methadone maintenance treatment (MMT) patients were recruited with records and measurements on methadone dose, plasma methadone concentrations, and treatment emergent symptom scales (TESS). 15 patients reported with skin irritation. Five SNPs located within the NECTIN4 genetic region were genotyped. The NECTIN4 gene within the adherens junction interaction pathway was associated with methadone dose in pathway-based genome wide association analyses (P = 0.0008). Three highly-linked SNPs, rs11265549, rs3820097, and rs4656978, were significantly associated with methadone dose (P = 0.0003), plasma concentrations of R,S-methadone (P = 0.0004) and TNF-α (P = 0.010) in all 344 MMT patients, and with self-report skin irritation symptom scores (P = 0.010) in the 15 MMT patients who reported with skin irritation. To identify the possible roles of plasma level of Nectin-4 in the responses to MMT and opioid use, additional age- and gender-matched 51 controls and 83 methadone-free abstinent former heroin users were recruited. Plasma level of Nectin-4 was the highest in MMT patients among the three groups. The results suggest involvement of genetic variants on NECTIN4 in methadone dose. Plasma Nectin-4 level is likely an indicator for continued use of opioids.</description><subject>Adult</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Antibodies</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Cell adhesion & migration</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Clinical trials</subject><subject>Complications and side effects</subject><subject>Cytokines</subject><subject>Dose-response relationship</subject><subject>Drug abuse</subject><subject>Drug dosages</subject><subject>Drug metabolism</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic variance</subject><subject>Genetic variation</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Heroin</subject><subject>Heroin Dependence - blood</subject><subject>Heroin Dependence - drug therapy</subject><subject>Heroin Dependence - genetics</subject><subject>Heroin Dependence - pathology</subject><subject>Humans</subject><subject>Irritation</subject><subject>Maintenance</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Methadone</subject><subject>Methadone - administration & dosage</subject><subject>Methadone - adverse effects</subject><subject>Methadone - blood</subject><subject>Narcotics</subject><subject>Nectin</subject><subject>Opiate Substitution Treatment - methods</subject><subject>Opioid-Related Disorders - blood</subject><subject>Opioid-Related Disorders - drug therapy</subject><subject>Opioid-Related Disorders - genetics</subject><subject>Opioid-Related Disorders - pathology</subject><subject>Opioids</subject><subject>Plasma</subject><subject>Single-nucleotide polymorphism</subject><subject>Skin</subject><subject>Social Sciences</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl-L1DAUxYso7jr6DUQLguDDjPnf5kVYhnUdWHZBV19Dmt7OZOkkY5Ku-u3NON1lCgoSStL0d0_Sc09RvMRogWmF39_6ITjdL3bewQIRyjiTj4pTLCmZC4Lo46P1SfEsxluEOK2FeFqcUMI5F6g-LZoLcJCsKe90sNqlWFpXXp0vb1ZXrARnfGvdutSu1O0GovWu3PoezNBDqUN-YvTG6gRt-cOmTWm8S9YN-dXvrLdtOUR4XjzpdB_hxTjPiq8fz2-Wn-aX1xer5dnl3AhJ0pxJQTgCgiuglKEGADeYECJJXQkGmhtEaowYrzG0VdewhlJUk_zbRkrR1HRWvD7o7nof1WhPVIRhVhFGJM_E6kC0Xt-qXbBbHX4pr636s-HDWumQzehBcVoBJkwLyQXr6rpGkhEGGAwjnHCWtT6Mpw3NFloDLgXdT0SnX5zdqLW_UxVFRAiRBd6MAsF_HyCmf1x5pNY638q6zmcxs7XRqDNBhKwwz72fFYu_UHm0sLW5J9DZvD8peDcp2PcNfqa1HmJUqy-f_5-9_jZl3x6xG9B92kTfDyknJ05BdgBN8DEG6B6cw0jt833vhtrnW435zmWvjl1_KLoPNP0NeWTyng</recordid><startdate>20200618</startdate><enddate>20200618</enddate><creator>Fang, Chiu-Ping</creator><creator>Liu, Tung-Hsia</creator><creator>Chung, Ren-Hua</creator><creator>Tsou, Hsiao-Hui</creator><creator>Kuo, Hsiang-Wei</creator><creator>Wang, Sheng-Chang</creator><creator>Liu, Chia-Chen</creator><creator>Liu, Shu Chih</creator><creator>Chen, Andrew C H</creator><creator>Liu, Yu-Li</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7519-2965</orcidid></search><sort><creationdate>20200618</creationdate><title>Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use</title><author>Fang, Chiu-Ping ; Liu, Tung-Hsia ; Chung, Ren-Hua ; Tsou, Hsiao-Hui ; Kuo, Hsiang-Wei ; Wang, Sheng-Chang ; Liu, Chia-Chen ; Liu, Shu Chih ; Chen, Andrew C H ; Liu, Yu-Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-496250e217e3340bee1b1222928764ea5c028104581ed7fb4b33082454c996b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Antibodies</topic><topic>Bioinformatics</topic><topic>Biology and Life Sciences</topic><topic>Cell adhesion & migration</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Clinical trials</topic><topic>Complications and side effects</topic><topic>Cytokines</topic><topic>Dose-response relationship</topic><topic>Drug abuse</topic><topic>Drug dosages</topic><topic>Drug metabolism</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic variance</topic><topic>Genetic variation</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Health sciences</topic><topic>Heroin</topic><topic>Heroin Dependence - blood</topic><topic>Heroin Dependence - drug therapy</topic><topic>Heroin Dependence - genetics</topic><topic>Heroin Dependence - pathology</topic><topic>Humans</topic><topic>Irritation</topic><topic>Maintenance</topic><topic>Male</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Methadone</topic><topic>Methadone - administration & dosage</topic><topic>Methadone - adverse effects</topic><topic>Methadone - blood</topic><topic>Narcotics</topic><topic>Nectin</topic><topic>Opiate Substitution Treatment - methods</topic><topic>Opioid-Related Disorders - blood</topic><topic>Opioid-Related Disorders - drug therapy</topic><topic>Opioid-Related Disorders - genetics</topic><topic>Opioid-Related Disorders - pathology</topic><topic>Opioids</topic><topic>Plasma</topic><topic>Single-nucleotide polymorphism</topic><topic>Skin</topic><topic>Social Sciences</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Chiu-Ping</creatorcontrib><creatorcontrib>Liu, Tung-Hsia</creatorcontrib><creatorcontrib>Chung, Ren-Hua</creatorcontrib><creatorcontrib>Tsou, Hsiao-Hui</creatorcontrib><creatorcontrib>Kuo, Hsiang-Wei</creatorcontrib><creatorcontrib>Wang, Sheng-Chang</creatorcontrib><creatorcontrib>Liu, Chia-Chen</creatorcontrib><creatorcontrib>Liu, Shu Chih</creatorcontrib><creatorcontrib>Chen, Andrew C H</creatorcontrib><creatorcontrib>Liu, Yu-Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Skin irritation is one of the adverse events caused by opioid use. 344 methadone maintenance treatment (MMT) patients were recruited with records and measurements on methadone dose, plasma methadone concentrations, and treatment emergent symptom scales (TESS). 15 patients reported with skin irritation. Five SNPs located within the NECTIN4 genetic region were genotyped. The NECTIN4 gene within the adherens junction interaction pathway was associated with methadone dose in pathway-based genome wide association analyses (P = 0.0008). Three highly-linked SNPs, rs11265549, rs3820097, and rs4656978, were significantly associated with methadone dose (P = 0.0003), plasma concentrations of R,S-methadone (P = 0.0004) and TNF-α (P = 0.010) in all 344 MMT patients, and with self-report skin irritation symptom scores (P = 0.010) in the 15 MMT patients who reported with skin irritation. To identify the possible roles of plasma level of Nectin-4 in the responses to MMT and opioid use, additional age- and gender-matched 51 controls and 83 methadone-free abstinent former heroin users were recruited. Plasma level of Nectin-4 was the highest in MMT patients among the three groups. The results suggest involvement of genetic variants on NECTIN4 in methadone dose. Plasma Nectin-4 level is likely an indicator for continued use of opioids.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32555608</pmid><doi>10.1371/journal.pone.0234549</doi><tpages>e0234549</tpages><orcidid>https://orcid.org/0000-0001-7519-2965</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-06, Vol.15 (6), p.e0234549 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2414724295 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Antibodies Bioinformatics Biology and Life Sciences Cell adhesion & migration Cell Adhesion Molecules - blood Cell Adhesion Molecules - genetics Clinical trials Complications and side effects Cytokines Dose-response relationship Drug abuse Drug dosages Drug metabolism Enzymes Female Gene expression Genetic aspects Genetic diversity Genetic Predisposition to Disease Genetic variance Genetic variation Genome-Wide Association Study Genomes Health aspects Health sciences Heroin Heroin Dependence - blood Heroin Dependence - drug therapy Heroin Dependence - genetics Heroin Dependence - pathology Humans Irritation Maintenance Male Medical records Medical research Medicine and Health Sciences Methadone Methadone - administration & dosage Methadone - adverse effects Methadone - blood Narcotics Nectin Opiate Substitution Treatment - methods Opioid-Related Disorders - blood Opioid-Related Disorders - drug therapy Opioid-Related Disorders - genetics Opioid-Related Disorders - pathology Opioids Plasma Single-nucleotide polymorphism Skin Social Sciences Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T04%3A57%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20variants%20in%20NECTIN4%20encoding%20an%20adhesion%20molecule%20are%20associated%20with%20continued%20opioid%20use&rft.jtitle=PloS%20one&rft.au=Fang,%20Chiu-Ping&rft.date=2020-06-18&rft.volume=15&rft.issue=6&rft.spage=e0234549&rft.pages=e0234549-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0234549&rft_dat=%3Cgale_plos_%3EA626971502%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2414724295&rft_id=info:pmid/32555608&rft_galeid=A626971502&rft_doaj_id=oai_doaj_org_article_537e124a69564f88809424e1ec425254&rfr_iscdi=true |