Use of microwave ablation for thermal treatment of solid tumors with different shapes and sizes-A computational approach
Microwave Ablation (MWA) is one of the most recent developments in the field of thermal therapy. This approach is an effective method for thermal tumor ablation by increasing the temperature above the normal physiological threshold to kill cancer cells with minimum side effects to surrounding organs...
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| description | Microwave Ablation (MWA) is one of the most recent developments in the field of thermal therapy. This approach is an effective method for thermal tumor ablation by increasing the temperature above the normal physiological threshold to kill cancer cells with minimum side effects to surrounding organs due to rapid heat dispersive tissues. In the present study, the effects of the shape and size of the tumor on MWA are investigated. To obtain the temperature gradient, coupled bio-heat and electromagnetic equations are solved using a three-dimensional finite element method (FEM). To extract cellular response at different temperatures and times, the three-state mathematical model was employed to achieve the ablation zone size. Results show that treatment of larger tumors is more difficult than that of smaller ones. By doubling the diameter of the tumor, the percentage of dead cancer cells is reduced by 20%. For a spherical tumor smaller than 2 cm, applying 50 W input power compared to 25 W has no significant effects on treatment efficiency and only increases the risk of damage to adjacent tissues. However, for tumors larger than 2 cm, it can increase the ablation zone up to 21%. In the spherical and oblate tumors, the mean percentage of dead cells at 6 GHz is nearly 30% higher than that at 2.45GHz, but for prolate tumors, treatment efficacy is reduced by 10% at a higher frequency. Moreover, the distance between two slots in the coaxial double slot antenna is modified based on the best treatment of prolate tumors. The findings of this study can be used to choose the optimum frequency and the best antenna design according to the shape and size of the tumor. |
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This approach is an effective method for thermal tumor ablation by increasing the temperature above the normal physiological threshold to kill cancer cells with minimum side effects to surrounding organs due to rapid heat dispersive tissues. In the present study, the effects of the shape and size of the tumor on MWA are investigated. To obtain the temperature gradient, coupled bio-heat and electromagnetic equations are solved using a three-dimensional finite element method (FEM). To extract cellular response at different temperatures and times, the three-state mathematical model was employed to achieve the ablation zone size. Results show that treatment of larger tumors is more difficult than that of smaller ones. By doubling the diameter of the tumor, the percentage of dead cancer cells is reduced by 20%. For a spherical tumor smaller than 2 cm, applying 50 W input power compared to 25 W has no significant effects on treatment efficiency and only increases the risk of damage to adjacent tissues. However, for tumors larger than 2 cm, it can increase the ablation zone up to 21%. In the spherical and oblate tumors, the mean percentage of dead cells at 6 GHz is nearly 30% higher than that at 2.45GHz, but for prolate tumors, treatment efficacy is reduced by 10% at a higher frequency. Moreover, the distance between two slots in the coaxial double slot antenna is modified based on the best treatment of prolate tumors. The findings of this study can be used to choose the optimum frequency and the best antenna design according to the shape and size of the tumor.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0233219</identifier><identifier>PMID: 32542034</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Ablation ; Ablation (Surgery) ; Ablation Techniques - methods ; Antenna design ; Antennas ; Apoptosis ; Bioengineering ; Biology and Life Sciences ; Cancer ; Care and treatment ; Cell death ; Computational Biology - methods ; Computer applications ; Computer engineering ; Computer Simulation ; Diameters ; Dielectric properties ; Efficiency ; Electromagnetic Phenomena ; Engineering and Technology ; Equipment Design ; Fever ; Finite Element Analysis ; Finite element method ; Heat transfer ; Heat treatment ; Humans ; Hyperthermia ; Liver ; Mathematical models ; Mechanical engineering ; Medicine and Health Sciences ; Methods ; Microwave ablation ; Microwaves - therapeutic use ; Models, Theoretical ; Neoplasms - therapy ; Organs ; Physical Sciences ; Physiological effects ; Radiofrequency Ablation - methods ; Research and Analysis Methods ; Shape effects ; Side effects ; Slot antennas ; Solid tumors ; Temperature ; Temperature gradients ; Thermotherapy ; Tumors</subject><ispartof>PloS one, 2020-06, Vol.15 (6), p.e0233219</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Tehrani et al. 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For a spherical tumor smaller than 2 cm, applying 50 W input power compared to 25 W has no significant effects on treatment efficiency and only increases the risk of damage to adjacent tissues. However, for tumors larger than 2 cm, it can increase the ablation zone up to 21%. In the spherical and oblate tumors, the mean percentage of dead cells at 6 GHz is nearly 30% higher than that at 2.45GHz, but for prolate tumors, treatment efficacy is reduced by 10% at a higher frequency. Moreover, the distance between two slots in the coaxial double slot antenna is modified based on the best treatment of prolate tumors. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tehrani, Masoud H H</au><au>Soltani, M</au><au>Kashkooli, Farshad Moradi</au><au>Raahemifar, Kaamran</au><au>Paliouras, Miltiadis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of microwave ablation for thermal treatment of solid tumors with different shapes and sizes-A computational approach</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-06-15</date><risdate>2020</risdate><volume>15</volume><issue>6</issue><spage>e0233219</spage><pages>e0233219-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Microwave Ablation (MWA) is one of the most recent developments in the field of thermal therapy. This approach is an effective method for thermal tumor ablation by increasing the temperature above the normal physiological threshold to kill cancer cells with minimum side effects to surrounding organs due to rapid heat dispersive tissues. In the present study, the effects of the shape and size of the tumor on MWA are investigated. To obtain the temperature gradient, coupled bio-heat and electromagnetic equations are solved using a three-dimensional finite element method (FEM). To extract cellular response at different temperatures and times, the three-state mathematical model was employed to achieve the ablation zone size. Results show that treatment of larger tumors is more difficult than that of smaller ones. By doubling the diameter of the tumor, the percentage of dead cancer cells is reduced by 20%. For a spherical tumor smaller than 2 cm, applying 50 W input power compared to 25 W has no significant effects on treatment efficiency and only increases the risk of damage to adjacent tissues. However, for tumors larger than 2 cm, it can increase the ablation zone up to 21%. In the spherical and oblate tumors, the mean percentage of dead cells at 6 GHz is nearly 30% higher than that at 2.45GHz, but for prolate tumors, treatment efficacy is reduced by 10% at a higher frequency. Moreover, the distance between two slots in the coaxial double slot antenna is modified based on the best treatment of prolate tumors. The findings of this study can be used to choose the optimum frequency and the best antenna design according to the shape and size of the tumor.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32542034</pmid><doi>10.1371/journal.pone.0233219</doi><tpages>e0233219</tpages><orcidid>https://orcid.org/0000-0003-0878-6274</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Ablation Ablation (Surgery) Ablation Techniques - methods Antenna design Antennas Apoptosis Bioengineering Biology and Life Sciences Cancer Care and treatment Cell death Computational Biology - methods Computer applications Computer engineering Computer Simulation Diameters Dielectric properties Efficiency Electromagnetic Phenomena Engineering and Technology Equipment Design Fever Finite Element Analysis Finite element method Heat transfer Heat treatment Humans Hyperthermia Liver Mathematical models Mechanical engineering Medicine and Health Sciences Methods Microwave ablation Microwaves - therapeutic use Models, Theoretical Neoplasms - therapy Organs Physical Sciences Physiological effects Radiofrequency Ablation - methods Research and Analysis Methods Shape effects Side effects Slot antennas Solid tumors Temperature Temperature gradients Thermotherapy Tumors |
| title | Use of microwave ablation for thermal treatment of solid tumors with different shapes and sizes-A computational approach |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T04%3A42%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20microwave%20ablation%20for%20thermal%20treatment%20of%20solid%20tumors%20with%20different%20shapes%20and%20sizes-A%20computational%20approach&rft.jtitle=PloS%20one&rft.au=Tehrani,%20Masoud%20H%20H&rft.date=2020-06-15&rft.volume=15&rft.issue=6&rft.spage=e0233219&rft.pages=e0233219-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0233219&rft_dat=%3Cgale_plos_%3EA626711009%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2413417342&rft_id=info:pmid/32542034&rft_galeid=A626711009&rft_doaj_id=oai_doaj_org_article_76ebf5fa3d9a45b68d76bdc0e1f18821&rfr_iscdi=true |