3D culture of functional human iPSC-derived hepatocytes using a core-shell microfiber

Human iPSC-derived hepatocytes hold great promise as a cell source for cell therapy and drug screening. However, the culture method for highly-quantified hepatocytes has not yet been established. Herein, we have developed an encapsulation and 3D cultivation method for iPSC-hepatocytes in core-shell...

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Veröffentlicht in:	PloS one 2020-06, Vol.15 (6), p.e0234441-e0234441
Hauptverfasser:	Nagata, Shogo, Ozawa, Fumisato, Nie, Minghao, Takeuchi, Shoji, Onoe, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Albumin Albumins Biology and Life Sciences Cell culture Cell therapy Cellular therapy Cultivation Culture Drug screening Extracellular matrix Fibers Gene expression Health aspects Hepatocytes Hydrogels Immunodeficiency Implantation Informatics Information science Liver cells Liver diseases Liver transplants Medicine and Health Sciences Methods Microfibers Peripheral blood Physical Sciences Research and Analysis Methods Screening Testing Transplantation
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