The health and economic burden of respiratory syncytial virus associated hospitalizations in adults
Respiratory syncytial virus (RSV) is increasingly recognized as an important cause of illness in adults; however, data on RSV disease and economic burden in this age group remain limited. We aimed to provide comprehensive estimates of RSV disease burden among adults aged ≥18 years. During 2012-2015,...
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| Veröffentlicht in: | PloS one 2020-06, Vol.15 (6), p.e0234235 |
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| creator | Prasad, Namrata Newbern, E Claire Trenholme, Adrian A Thompson, Mark G McArthur, Colin Wong, Conroy A Jelley, Lauren Aminisani, Nayyereh Huang, Q Sue Grant, Cameron C |
| description | Respiratory syncytial virus (RSV) is increasingly recognized as an important cause of illness in adults; however, data on RSV disease and economic burden in this age group remain limited. We aimed to provide comprehensive estimates of RSV disease burden among adults aged ≥18 years.
During 2012-2015, population-based, active surveillance of acute respiratory infection (ARI) hospitalizations enabled estimation of the seasonal incidence of RSV hospitalizations and direct health costs in adults aged ≥18 years in Auckland, New Zealand.
Of 4,600 ARI hospitalizations tested for RSV, 348 (7.6%) were RSV positive. The median (interquartile range) length of hospital stay for RSV positive patients was 4 (2-6) days. The seasonal incidence rate (IR) of RSV hospitalizations, corrected for non-testing, was 23.6 (95% confidence intervals [CI] 21.0-26.1) per 100,000 adults aged ≥18 years. Hospitalization risk increased with age with the highest incidence among adults aged ≥80 years (IR 190.8 per 100,000, 95% CI 137.6-244.0). Being of Māori or Pacific ethnicity or living in a neighborhood with low socioeconomic status (SES) were independently associated with increased RSV hospitalization rates. We estimate RSV-associated hospitalizations among adults aged ≥18 years to cost on average NZD $4,758 per event.
RSV infection is associated with considerable disease and economic cost in adults. RSV disproportionally affects adult sub-groups defined by age, ethnicity, and neighborhood SES. An effective RSV vaccine or RSV treatment may offer benefits for older adults. |
| doi_str_mv | 10.1371/journal.pone.0234235 |
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During 2012-2015, population-based, active surveillance of acute respiratory infection (ARI) hospitalizations enabled estimation of the seasonal incidence of RSV hospitalizations and direct health costs in adults aged ≥18 years in Auckland, New Zealand.
Of 4,600 ARI hospitalizations tested for RSV, 348 (7.6%) were RSV positive. The median (interquartile range) length of hospital stay for RSV positive patients was 4 (2-6) days. The seasonal incidence rate (IR) of RSV hospitalizations, corrected for non-testing, was 23.6 (95% confidence intervals [CI] 21.0-26.1) per 100,000 adults aged ≥18 years. Hospitalization risk increased with age with the highest incidence among adults aged ≥80 years (IR 190.8 per 100,000, 95% CI 137.6-244.0). Being of Māori or Pacific ethnicity or living in a neighborhood with low socioeconomic status (SES) were independently associated with increased RSV hospitalization rates. We estimate RSV-associated hospitalizations among adults aged ≥18 years to cost on average NZD $4,758 per event.
RSV infection is associated with considerable disease and economic cost in adults. RSV disproportionally affects adult sub-groups defined by age, ethnicity, and neighborhood SES. An effective RSV vaccine or RSV treatment may offer benefits for older adults.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0234235</identifier><identifier>PMID: 32525898</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Age ; Analysis ; Biology and life sciences ; Care and treatment ; Confidence intervals ; Cost of Illness ; Diagnosis ; Economic aspects ; Economic impact ; Economics ; Female ; Health care costs ; Hospitalization - statistics & numerical data ; Humans ; Immunization ; Infections ; Laboratories ; Male ; Medicine and Health Sciences ; Minority & ethnic groups ; Older people ; People and Places ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - economics ; Respiratory Syncytial Virus Infections - therapy ; Retrospective Studies ; Seasons ; Socioeconomics ; Studies ; Vaccines ; Viruses</subject><ispartof>PloS one, 2020-06, Vol.15 (6), p.e0234235</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-cf8dcd6dad5b2e9ef5c2d38a408c42e62adf8e14f402d48844ee4272841a2ff93</citedby><cites>FETCH-LOGICAL-c692t-cf8dcd6dad5b2e9ef5c2d38a408c42e62adf8e14f402d48844ee4272841a2ff93</cites><orcidid>0000-0002-2268-279X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289360/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289360/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32525898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>van Zyl-Smit, Richard</contributor><creatorcontrib>Prasad, Namrata</creatorcontrib><creatorcontrib>Newbern, E Claire</creatorcontrib><creatorcontrib>Trenholme, Adrian A</creatorcontrib><creatorcontrib>Thompson, Mark G</creatorcontrib><creatorcontrib>McArthur, Colin</creatorcontrib><creatorcontrib>Wong, Conroy A</creatorcontrib><creatorcontrib>Jelley, Lauren</creatorcontrib><creatorcontrib>Aminisani, Nayyereh</creatorcontrib><creatorcontrib>Huang, Q Sue</creatorcontrib><creatorcontrib>Grant, Cameron C</creatorcontrib><title>The health and economic burden of respiratory syncytial virus associated hospitalizations in adults</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Respiratory syncytial virus (RSV) is increasingly recognized as an important cause of illness in adults; however, data on RSV disease and economic burden in this age group remain limited. We aimed to provide comprehensive estimates of RSV disease burden among adults aged ≥18 years.
During 2012-2015, population-based, active surveillance of acute respiratory infection (ARI) hospitalizations enabled estimation of the seasonal incidence of RSV hospitalizations and direct health costs in adults aged ≥18 years in Auckland, New Zealand.
Of 4,600 ARI hospitalizations tested for RSV, 348 (7.6%) were RSV positive. The median (interquartile range) length of hospital stay for RSV positive patients was 4 (2-6) days. The seasonal incidence rate (IR) of RSV hospitalizations, corrected for non-testing, was 23.6 (95% confidence intervals [CI] 21.0-26.1) per 100,000 adults aged ≥18 years. Hospitalization risk increased with age with the highest incidence among adults aged ≥80 years (IR 190.8 per 100,000, 95% CI 137.6-244.0). Being of Māori or Pacific ethnicity or living in a neighborhood with low socioeconomic status (SES) were independently associated with increased RSV hospitalization rates. We estimate RSV-associated hospitalizations among adults aged ≥18 years to cost on average NZD $4,758 per event.
RSV infection is associated with considerable disease and economic cost in adults. RSV disproportionally affects adult sub-groups defined by age, ethnicity, and neighborhood SES. 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We aimed to provide comprehensive estimates of RSV disease burden among adults aged ≥18 years.
During 2012-2015, population-based, active surveillance of acute respiratory infection (ARI) hospitalizations enabled estimation of the seasonal incidence of RSV hospitalizations and direct health costs in adults aged ≥18 years in Auckland, New Zealand.
Of 4,600 ARI hospitalizations tested for RSV, 348 (7.6%) were RSV positive. The median (interquartile range) length of hospital stay for RSV positive patients was 4 (2-6) days. The seasonal incidence rate (IR) of RSV hospitalizations, corrected for non-testing, was 23.6 (95% confidence intervals [CI] 21.0-26.1) per 100,000 adults aged ≥18 years. Hospitalization risk increased with age with the highest incidence among adults aged ≥80 years (IR 190.8 per 100,000, 95% CI 137.6-244.0). Being of Māori or Pacific ethnicity or living in a neighborhood with low socioeconomic status (SES) were independently associated with increased RSV hospitalization rates. We estimate RSV-associated hospitalizations among adults aged ≥18 years to cost on average NZD $4,758 per event.
RSV infection is associated with considerable disease and economic cost in adults. RSV disproportionally affects adult sub-groups defined by age, ethnicity, and neighborhood SES. An effective RSV vaccine or RSV treatment may offer benefits for older adults.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32525898</pmid><doi>10.1371/journal.pone.0234235</doi><tpages>e0234235</tpages><orcidid>https://orcid.org/0000-0002-2268-279X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Directory of Open Access Journals (DOAJ); Public Library of Science (PLoS) Journals Open Access; PubMed (Medline); MEDLINE; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adult Adults Age Analysis Biology and life sciences Care and treatment Confidence intervals Cost of Illness Diagnosis Economic aspects Economic impact Economics Female Health care costs Hospitalization - statistics & numerical data Humans Immunization Infections Laboratories Male Medicine and Health Sciences Minority & ethnic groups Older people People and Places Respiratory syncytial virus Respiratory Syncytial Virus Infections - economics Respiratory Syncytial Virus Infections - therapy Retrospective Studies Seasons Socioeconomics Studies Vaccines Viruses |
| title | The health and economic burden of respiratory syncytial virus associated hospitalizations in adults |
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