DNA methylation patterns of LINE-1 and Alu for pre-symptomatic dementia in type 2 diabetes

The identification of early markers of dementia is important for higher-risk populations such as those with type 2 diabetes (T2D). Retrotransposons, including long interspersed nuclear element 1 (LINE-1) and Alu, comprise ~40% of the human genome. Although dysregulation of these retrotransposons can...

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Veröffentlicht in:	PloS one 2020-06, Vol.15 (6), p.e0234578-e0234578
Hauptverfasser:	Sae-Lee, Chanachai, Biasi, Julien De, Robinson, Natassia, Barrow, Timothy M, Mathers, John C, Koutsidis, Georgios, Byun, Hyang-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alu elements Alzheimer's disease Biology and life sciences Biomarkers Cancer Carbon Cognitive ability Complications and side effects Cyanocobalamin Datasets Dementia Dementia disorders Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet Dietary supplements DNA DNA methylation DNA probes DNA sequencing Epigenetics Folic acid Gene mapping Gene regulation Genes Genetic aspects Genomes Genomic instability Genotypes Health aspects Health sciences Homocysteine Life sciences Loci Long interspersed nucleotide elements Mapping Medicine and Health Sciences Metabolism Methylation Methylenetetrahydrofolate reductase Nervous system Neurodegenerative diseases Older people Physical Sciences Probes Risk Risk factors Studies Type 2 diabetes Vitamin B Vitamin B12
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