iPSCs from people with MS can differentiate into oligodendrocytes in a homeostatic but not an inflammatory milieu

Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that results in variable severities of neurodegeneration. The understanding of MS has been limited by the inaccessibility of the affected cells and the lengthy timeframe of disease development. H...

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Veröffentlicht in:	PloS one 2020-06, Vol.15 (6), p.e0233980
Hauptverfasser:	Morales Pantoja, Itzy E, Smith, Matthew D, Rajbhandari, Labchan, Cheng, Linzhao, Gao, Yongxing, Mahairaki, Vasiliki, Venkatesan, Arun, Calabresi, Peter A, Fitzgerald, Kathryn C, Whartenby, Katharine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Biological response modifiers Biology and Life Sciences Care and treatment Cell differentiation Cell Differentiation - drug effects Cells, Cultured Central nervous system Chronic exposure Cytokines Demyelinating diseases Demyelination Development and progression Differentiation Disabilities Diseases Environmental effects Exposure Genes Glia Glial stem cells Health aspects Homeostasis Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - physiology Inflammation - pathology Inhibitory postsynaptic potentials Interferon Interferon gamma Interferon-gamma - pharmacology Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Medicine Medicine and Health Sciences Multiple sclerosis Multiple Sclerosis, Chronic Progressive - pathology Neurodegeneration Neurology Neurons Oligodendrocytes Oligodendroglia - cytology Peripheral blood mononuclear cells Phenotypes Physiological aspects Pluripotency Regeneration Research and Analysis Methods Stem cells Technology γ-Interferon
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