Short-chain fructo-oligosaccharides supplementation to suckling piglets: Assessment of pre- and post-weaning performance and gut health
Farmers face difficulties in redeeming their investment in larger litter sizes since this comes with larger litter heterogenicity, lower litter resilience and risk of higher mortality. Dietary oligosaccharides, given to the sow, proved beneficial for the offspring's performance. However, giving...
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| Veröffentlicht in: | PloS one 2020-06, Vol.15 (6), p.e0233910-e0233910 |
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| creator | Ayuso, Miriam Michiels, Joris Wuyts, Sander Yan, Honglin Degroote, Jeroen Lebeer, Sarah Le Bourgot, Cindy Apper, Emmanuelle Majdeddin, Maryam Van Noten, Noémie Vanden Hole, Charlotte Van Cruchten, Steven Van Poucke, Mario Peelman, Luc Van Ginneken, Chris |
| description | Farmers face difficulties in redeeming their investment in larger litter sizes since this comes with larger litter heterogenicity, lower litter resilience and risk of higher mortality. Dietary oligosaccharides, given to the sow, proved beneficial for the offspring's performance. However, giving oligosaccharides to the suckling piglet is poorly explored. Therefore, this field trial studied the effect of dietary short-chain fructo-oligosaccharides (scFOS; 1g/day; drenched) supplementation to low (LBW, lower quartile), normal (NBW, two intermediate quartiles) and high (HBW, upper quartile) birth weight piglets from birth until 7 or 21 days of age. Performance parameters, gut microbiome and short-chain fatty acids profile of feces and digesta were assessed at birth (d 0), d 7, weaning (d 21.5) and 2 weeks post-weaning (d 36.5). Additional parameters reflecting gut health (intestinal integrity and morphology, mucosal immune system) were analysed at d 36.5. Most parameters changed with age or differed with the piglet's birth weight. Drenching with scFOS increased body weight by 1 kg in NBW suckling piglets and reduced the post-weaning mortality rate by a 100%. No clear difference in the IgG level, the microbiota composition and fermentative activity between the treatment groups was observed. Additionnally, intestinal integrity, determined by measuring intestinal permeability and regenerative capacity, was similar between the treatment groups. Also, intestinal architecture (villus lenght, crypt depth) was not affected by scFOS supplementation. The density of intra-epithelial lymphocytes and the expression profiles (real-time qPCR) for immune system-related genes (IL-10, IL-1ß, IL-6, TNF[alpha] and IFN[gamma]) were used to assess mucosal immunity. Only IFN[gamma] expression, was upregulated in piglets that received scFOS for 7 days. The improved body weight and the reduced post-weaning mortality seen in piglets supplemented with scFOS support the view that scFOS positively impact piglet's health and resilience. However, the modes of action for these effects are not yet fully elucidated and its potential to improve other performance parameters needs further investigation. |
| doi_str_mv | 10.1371/journal.pone.0233910 |
| format | Article |
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Dietary oligosaccharides, given to the sow, proved beneficial for the offspring's performance. However, giving oligosaccharides to the suckling piglet is poorly explored. Therefore, this field trial studied the effect of dietary short-chain fructo-oligosaccharides (scFOS; 1g/day; drenched) supplementation to low (LBW, lower quartile), normal (NBW, two intermediate quartiles) and high (HBW, upper quartile) birth weight piglets from birth until 7 or 21 days of age. Performance parameters, gut microbiome and short-chain fatty acids profile of feces and digesta were assessed at birth (d 0), d 7, weaning (d 21.5) and 2 weeks post-weaning (d 36.5). Additional parameters reflecting gut health (intestinal integrity and morphology, mucosal immune system) were analysed at d 36.5. Most parameters changed with age or differed with the piglet's birth weight. Drenching with scFOS increased body weight by 1 kg in NBW suckling piglets and reduced the post-weaning mortality rate by a 100%. No clear difference in the IgG level, the microbiota composition and fermentative activity between the treatment groups was observed. Additionnally, intestinal integrity, determined by measuring intestinal permeability and regenerative capacity, was similar between the treatment groups. Also, intestinal architecture (villus lenght, crypt depth) was not affected by scFOS supplementation. The density of intra-epithelial lymphocytes and the expression profiles (real-time qPCR) for immune system-related genes (IL-10, IL-1ß, IL-6, TNF[alpha] and IFN[gamma]) were used to assess mucosal immunity. Only IFN[gamma] expression, was upregulated in piglets that received scFOS for 7 days. The improved body weight and the reduced post-weaning mortality seen in piglets supplemented with scFOS support the view that scFOS positively impact piglet's health and resilience. However, the modes of action for these effects are not yet fully elucidated and its potential to improve other performance parameters needs further investigation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0233910</identifier><identifier>PMID: 32502215</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Animal behavior ; Animal sciences ; Aquatic ecology ; Bioengineering ; Biology and Life Sciences ; Birth weight ; Body weight ; Data collection ; Diet ; Dietary supplements ; Digestive system ; Digestive tract ; EDTA ; Engineering ; Farmers ; Fatty acids ; Feeds ; Fermentation ; Food and nutrition ; Fructooligosaccharides ; Gastrointestinal tract ; Gene expression ; Genes ; Health aspects ; Hogs ; Immune system ; Immunoglobulin G ; Integrity ; Interleukin 10 ; Interleukin 6 ; Intestinal microflora ; Intestine ; Laboratories ; Litter ; Litter size ; Lymphocytes ; Medicine and Health Sciences ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Morphology ; Mortality ; Mucosal immunity ; Nutrition ; Offspring ; Oligosaccharides ; Parameters ; Permeability ; Pharmaceuticals ; Product quality ; Quartiles ; Resilience ; Suckling behavior ; Suckling pig ; Swine ; Time ; Tumor necrosis factor-α ; Veterinary dietary supplements ; Veterinary medicine ; Villus ; Weaning ; Weight reduction ; γ-Interferon</subject><ispartof>PloS one, 2020-06, Vol.15 (6), p.e0233910-e0233910</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Ayuso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Ayuso et al 2020 Ayuso et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-144da8ab1a6348bc9847ec2add8e82b1f3d8f5f28592480df6647359dd1533a43</citedby><cites>FETCH-LOGICAL-c669t-144da8ab1a6348bc9847ec2add8e82b1f3d8f5f28592480df6647359dd1533a43</cites><orcidid>0000-0001-6045-394X ; 0000-0002-9597-9404</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274435/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274435/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids></links><search><contributor>Loor, Juan J.</contributor><creatorcontrib>Ayuso, Miriam</creatorcontrib><creatorcontrib>Michiels, Joris</creatorcontrib><creatorcontrib>Wuyts, Sander</creatorcontrib><creatorcontrib>Yan, Honglin</creatorcontrib><creatorcontrib>Degroote, Jeroen</creatorcontrib><creatorcontrib>Lebeer, Sarah</creatorcontrib><creatorcontrib>Le Bourgot, Cindy</creatorcontrib><creatorcontrib>Apper, Emmanuelle</creatorcontrib><creatorcontrib>Majdeddin, Maryam</creatorcontrib><creatorcontrib>Van Noten, Noémie</creatorcontrib><creatorcontrib>Vanden Hole, Charlotte</creatorcontrib><creatorcontrib>Van Cruchten, Steven</creatorcontrib><creatorcontrib>Van Poucke, Mario</creatorcontrib><creatorcontrib>Peelman, Luc</creatorcontrib><creatorcontrib>Van Ginneken, Chris</creatorcontrib><title>Short-chain fructo-oligosaccharides supplementation to suckling piglets: Assessment of pre- and post-weaning performance and gut health</title><title>PloS one</title><description>Farmers face difficulties in redeeming their investment in larger litter sizes since this comes with larger litter heterogenicity, lower litter resilience and risk of higher mortality. Dietary oligosaccharides, given to the sow, proved beneficial for the offspring's performance. However, giving oligosaccharides to the suckling piglet is poorly explored. Therefore, this field trial studied the effect of dietary short-chain fructo-oligosaccharides (scFOS; 1g/day; drenched) supplementation to low (LBW, lower quartile), normal (NBW, two intermediate quartiles) and high (HBW, upper quartile) birth weight piglets from birth until 7 or 21 days of age. Performance parameters, gut microbiome and short-chain fatty acids profile of feces and digesta were assessed at birth (d 0), d 7, weaning (d 21.5) and 2 weeks post-weaning (d 36.5). Additional parameters reflecting gut health (intestinal integrity and morphology, mucosal immune system) were analysed at d 36.5. Most parameters changed with age or differed with the piglet's birth weight. Drenching with scFOS increased body weight by 1 kg in NBW suckling piglets and reduced the post-weaning mortality rate by a 100%. No clear difference in the IgG level, the microbiota composition and fermentative activity between the treatment groups was observed. Additionnally, intestinal integrity, determined by measuring intestinal permeability and regenerative capacity, was similar between the treatment groups. Also, intestinal architecture (villus lenght, crypt depth) was not affected by scFOS supplementation. The density of intra-epithelial lymphocytes and the expression profiles (real-time qPCR) for immune system-related genes (IL-10, IL-1ß, IL-6, TNF[alpha] and IFN[gamma]) were used to assess mucosal immunity. Only IFN[gamma] expression, was upregulated in piglets that received scFOS for 7 days. The improved body weight and the reduced post-weaning mortality seen in piglets supplemented with scFOS support the view that scFOS positively impact piglet's health and resilience. However, the modes of action for these effects are not yet fully elucidated and its potential to improve other performance parameters needs further investigation.</description><subject>Animal behavior</subject><subject>Animal sciences</subject><subject>Aquatic ecology</subject><subject>Bioengineering</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Body weight</subject><subject>Data collection</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Digestive system</subject><subject>Digestive tract</subject><subject>EDTA</subject><subject>Engineering</subject><subject>Farmers</subject><subject>Fatty acids</subject><subject>Feeds</subject><subject>Fermentation</subject><subject>Food and nutrition</subject><subject>Fructooligosaccharides</subject><subject>Gastrointestinal tract</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Hogs</subject><subject>Immune system</subject><subject>Immunoglobulin G</subject><subject>Integrity</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Laboratories</subject><subject>Litter</subject><subject>Litter size</subject><subject>Lymphocytes</subject><subject>Medicine and Health Sciences</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Morphology</subject><subject>Mortality</subject><subject>Mucosal immunity</subject><subject>Nutrition</subject><subject>Offspring</subject><subject>Oligosaccharides</subject><subject>Parameters</subject><subject>Permeability</subject><subject>Pharmaceuticals</subject><subject>Product quality</subject><subject>Quartiles</subject><subject>Resilience</subject><subject>Suckling behavior</subject><subject>Suckling pig</subject><subject>Swine</subject><subject>Time</subject><subject>Tumor necrosis factor-α</subject><subject>Veterinary dietary supplements</subject><subject>Veterinary medicine</subject><subject>Villus</subject><subject>Weaning</subject><subject>Weight 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Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayuso, Miriam</au><au>Michiels, Joris</au><au>Wuyts, Sander</au><au>Yan, Honglin</au><au>Degroote, Jeroen</au><au>Lebeer, Sarah</au><au>Le Bourgot, Cindy</au><au>Apper, Emmanuelle</au><au>Majdeddin, Maryam</au><au>Van Noten, Noémie</au><au>Vanden Hole, Charlotte</au><au>Van Cruchten, Steven</au><au>Van Poucke, Mario</au><au>Peelman, Luc</au><au>Van Ginneken, Chris</au><au>Loor, Juan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-chain fructo-oligosaccharides supplementation to suckling piglets: Assessment of pre- and post-weaning performance and gut health</atitle><jtitle>PloS one</jtitle><date>2020-06-05</date><risdate>2020</risdate><volume>15</volume><issue>6</issue><spage>e0233910</spage><epage>e0233910</epage><pages>e0233910-e0233910</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Farmers face difficulties in redeeming their investment in larger litter sizes since this comes with larger litter heterogenicity, lower litter resilience and risk of higher mortality. Dietary oligosaccharides, given to the sow, proved beneficial for the offspring's performance. However, giving oligosaccharides to the suckling piglet is poorly explored. Therefore, this field trial studied the effect of dietary short-chain fructo-oligosaccharides (scFOS; 1g/day; drenched) supplementation to low (LBW, lower quartile), normal (NBW, two intermediate quartiles) and high (HBW, upper quartile) birth weight piglets from birth until 7 or 21 days of age. Performance parameters, gut microbiome and short-chain fatty acids profile of feces and digesta were assessed at birth (d 0), d 7, weaning (d 21.5) and 2 weeks post-weaning (d 36.5). Additional parameters reflecting gut health (intestinal integrity and morphology, mucosal immune system) were analysed at d 36.5. Most parameters changed with age or differed with the piglet's birth weight. Drenching with scFOS increased body weight by 1 kg in NBW suckling piglets and reduced the post-weaning mortality rate by a 100%. No clear difference in the IgG level, the microbiota composition and fermentative activity between the treatment groups was observed. Additionnally, intestinal integrity, determined by measuring intestinal permeability and regenerative capacity, was similar between the treatment groups. Also, intestinal architecture (villus lenght, crypt depth) was not affected by scFOS supplementation. The density of intra-epithelial lymphocytes and the expression profiles (real-time qPCR) for immune system-related genes (IL-10, IL-1ß, IL-6, TNF[alpha] and IFN[gamma]) were used to assess mucosal immunity. Only IFN[gamma] expression, was upregulated in piglets that received scFOS for 7 days. The improved body weight and the reduced post-weaning mortality seen in piglets supplemented with scFOS support the view that scFOS positively impact piglet's health and resilience. However, the modes of action for these effects are not yet fully elucidated and its potential to improve other performance parameters needs further investigation.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32502215</pmid><doi>10.1371/journal.pone.0233910</doi><tpages>e0233910</tpages><orcidid>https://orcid.org/0000-0001-6045-394X</orcidid><orcidid>https://orcid.org/0000-0002-9597-9404</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-06, Vol.15 (6), p.e0233910-e0233910 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2409870214 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animal behavior Animal sciences Aquatic ecology Bioengineering Biology and Life Sciences Birth weight Body weight Data collection Diet Dietary supplements Digestive system Digestive tract EDTA Engineering Farmers Fatty acids Feeds Fermentation Food and nutrition Fructooligosaccharides Gastrointestinal tract Gene expression Genes Health aspects Hogs Immune system Immunoglobulin G Integrity Interleukin 10 Interleukin 6 Intestinal microflora Intestine Laboratories Litter Litter size Lymphocytes Medicine and Health Sciences Microbiomes Microbiota Microbiota (Symbiotic organisms) Morphology Mortality Mucosal immunity Nutrition Offspring Oligosaccharides Parameters Permeability Pharmaceuticals Product quality Quartiles Resilience Suckling behavior Suckling pig Swine Time Tumor necrosis factor-α Veterinary dietary supplements Veterinary medicine Villus Weaning Weight reduction γ-Interferon |
| title | Short-chain fructo-oligosaccharides supplementation to suckling piglets: Assessment of pre- and post-weaning performance and gut health |
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