$Clinical efficacy and safety of drug interventions for primary and secondary prevention of osteoporotic fractures in postmenopausal women: Network meta-analysis followed by factor and cluster analysis$

Clinical efficacy and safety of drug interventions for primary and secondary prevention of osteoporotic fractures in postmenopausal women: Network meta-analysis followed by factor and cluster analysis

We aimed to evaluate the comparative efficacy and safety of drugs respectively for primary prevention and secondary prevention of osteoporotic fractures in postmenopausal women (PMW), and to further identify the optimal intervention(s) respectively for the two groups when efficacy and safety both co...

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Veröffentlicht in:	PloS one 2020-06, Vol.15 (6), p.e0234123
Hauptverfasser:	Wen, Fei, Du, Hongheng, Ding, Liangliang, Hu, Jinxi, Huang, Zifeng, Huang, Hua, Li, Kaikai, Mo, Yuxia, Kuang, Anyin
Format:	Artikel
Sprache:	eng
Schlagworte:	Abaloparatide Alendronate Alendronic acid Bayes Theorem Bayesian analysis Bazedoxifene Biology and Life Sciences Biomedical materials Bisphosphonates Bone density Bone Density Conservation Agents - adverse effects Bone Density Conservation Agents - therapeutic use Bone disorder agents Clinical trials Cluster Analysis Computer and Information Sciences Confidence intervals Databases, Factual Demographic aspects Denosumab Dose-Response Relationship, Drug Drug Administration Schedule Drug therapy Drugs Female Fractures Fractures (Injuries) Hospitals Humans Intervention Medicine and Health Sciences Meta-analysis Monoclonal antibodies Orthopedics Osteoporosis Osteoporotic Fractures - pathology Osteoporotic Fractures - prevention & control Parathyroid hormone Parathyroid hormones Physical Sciences Post-menopause Postmenopausal women Postmenopause Prevention Proportional Hazards Models Research and Analysis Methods Risedronic acid Risk Safety Secondary Prevention Studies Treatment Outcome Vertebrae Women Zoledronate Zoledronic acid Zoledronic Acid - adverse effects Zoledronic Acid - therapeutic use
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