Distribution of class 1 integrons in historic and contemporary collections of human pathogenic Escherichia coli
Integrons play a major role in the evolution and spread of antimicrobial resistance in human pathogens, including Escherichia coli. This study describes the occurrence of class 1 integrons in human pathogenic E. coli, in three isolate collections involving three periods from the last 100 years (i) t...
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| description | Integrons play a major role in the evolution and spread of antimicrobial resistance in human pathogens, including Escherichia coli. This study describes the occurrence of class 1 integrons in human pathogenic E. coli, in three isolate collections involving three periods from the last 100 years (i) the Murray collection (n = 58 bacteria isolated from the 1910s to 1940s); (ii) the E. coli reference (ECOR) collection (n = 37 isolates mainly from the 1980s); and (iii) a recently assembled collection (n = 88 isolates obtained in 2016). High-quality whole genome sequences (WGSs) were available for all isolates. Integrons were detected in the WGSs with the program IntegronFinder and the results compared with three established methods: (i) polymerase chain reaction detection of the integrase gene; (ii) BLAST searching using draft genomes; and (iii) mapping of short reads. No integrons were found in any of the Murray Collection isolates; however, integrons were present in 3% of the isolates from ECOR collection, assembled in the 1980s, and 26% of the isolates from the 2010s. Similarly, antimicrobial resistance determinants were not present in the Murray Collection isolates, whereas they were present in 19% of the ECOR Collection isolates and in 55% of the isolates obtained in during the 2010s. |
| doi_str_mv | 10.1371/journal.pone.0233315 |
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Integrons were detected in the WGSs with the program IntegronFinder and the results compared with three established methods: (i) polymerase chain reaction detection of the integrase gene; (ii) BLAST searching using draft genomes; and (iii) mapping of short reads. No integrons were found in any of the Murray Collection isolates; however, integrons were present in 3% of the isolates from ECOR collection, assembled in the 1980s, and 26% of the isolates from the 2010s. 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J</au><au>Tano, Eva</au><au>Chang, Yung-Fu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of class 1 integrons in historic and contemporary collections of human pathogenic Escherichia coli</atitle><jtitle>PloS one</jtitle><date>2020-06-02</date><risdate>2020</risdate><volume>15</volume><issue>6</issue><spage>e0233315</spage><epage>e0233315</epage><pages>e0233315-e0233315</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Integrons play a major role in the evolution and spread of antimicrobial resistance in human pathogens, including Escherichia coli. This study describes the occurrence of class 1 integrons in human pathogenic E. coli, in three isolate collections involving three periods from the last 100 years (i) the Murray collection (n = 58 bacteria isolated from the 1910s to 1940s); (ii) the E. coli reference (ECOR) collection (n = 37 isolates mainly from the 1980s); and (iii) a recently assembled collection (n = 88 isolates obtained in 2016). High-quality whole genome sequences (WGSs) were available for all isolates. Integrons were detected in the WGSs with the program IntegronFinder and the results compared with three established methods: (i) polymerase chain reaction detection of the integrase gene; (ii) BLAST searching using draft genomes; and (iii) mapping of short reads. No integrons were found in any of the Murray Collection isolates; however, integrons were present in 3% of the isolates from ECOR collection, assembled in the 1980s, and 26% of the isolates from the 2010s. Similarly, antimicrobial resistance determinants were not present in the Murray Collection isolates, whereas they were present in 19% of the ECOR Collection isolates and in 55% of the isolates obtained in during the 2010s.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32484827</pmid><doi>10.1371/journal.pone.0233315</doi><tpages>e0233315</tpages><orcidid>https://orcid.org/0000-0001-6321-5138</orcidid><orcidid>https://orcid.org/0000-0002-5765-8597</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibiotics Antimicrobial agents Antimicrobial resistance Bacteria Biology and Life Sciences Collection Deoxyribonucleic acid Distribution DNA Drug resistance E coli Escherichia coli Explosions Gene mapping Gene sequencing Genes Genetic aspects Genomes Genomics Health aspects Identification and classification Integrase Integrons Mapping Maternal & child health Medicine and Health Sciences Microbial drug resistance Natural history Pathogenic microorganisms Pathogens Plasmids Polymerase chain reaction Research and Analysis Methods Zoology |
| title | Distribution of class 1 integrons in historic and contemporary collections of human pathogenic Escherichia coli |
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