Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake

Disruption of blood-brain barrier integrity and dramatic failure of brain ion homeostasis including fluctuations of pH occurs during cortical spreading depression (CSD) events associated with several neurological disorders, including migraine with aura, traumatic brain injury and stroke. NHE1 is the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0227463
Hauptverfasser:	Liktor-Busa, Erika, Blawn, Kiera T, Kellohen, Kathryn L, Wiese, Beth M, Verkhovsky, Vani, Wahl, Jared, Vivek, Anjali, Palomino, Seph M, Davis, Thomas P, Vanderah, Todd W, Largent-Milnes, Tally M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Blood-brain barrier Blood-Brain Barrier - metabolism Brain - drug effects Brain - pathology Cell lines Central nervous system Central Nervous System - drug effects Central Nervous System - pathology Cortical spreading depression Cortical Spreading Depression - drug effects Cortical Spreading Depression - genetics Disease Models, Animal Dosage and administration Drug metabolism Endothelial cells Endothelial Cells - drug effects Female Ganglia Gene Expression Regulation - drug effects Genetic aspects Head injuries Headache Headaches Health aspects Homeostasis Humans Hydrogen Injections, Intraperitoneal Integrity Laboratory animals Medicine and Health Sciences Migraine Migraine with Aura - drug therapy Migraine with Aura - genetics Migraine with Aura - pathology Na+/H+-exchanging ATPase Neurological diseases Pain Permeability pH effects Pharmacology Potassium chloride Rats Sensitivity Sodium-Hydrogen Exchanger 1 - antagonists & inhibitors Sodium-Hydrogen Exchanger 1 - genetics Sucrose Sugar Sumatriptan Sumatriptan - pharmacology Transport proteins Traumatic brain injury Trigeminal ganglion Trigeminal Ganglion - drug effects Trigeminal Ganglion - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!