Influenza vaccine efficacy induced by orally administered recombinant baculoviruses
Although vaccine delivery through the oral route remains the most convenient and safest way for mass immunization purposes, this method is limited by the requirement for large antigen doses and low vaccine efficacy. In this study, we generated recombinant baculoviruses (rBVs) expressing influenza he...
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| Veröffentlicht in: | PloS one 2020-05, Vol.15 (5), p.e0233520-e0233520 |
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| creator | Basak, Swarnendu Kang, Hae-Ji Lee, Su-Hwa Chu, Ki-Back Moon, Eun-Kyung Quan, Fu-Shi |
| description | Although vaccine delivery through the oral route remains the most convenient and safest way for mass immunization purposes, this method is limited by the requirement for large antigen doses and low vaccine efficacy. In this study, we generated recombinant baculoviruses (rBVs) expressing influenza hemagglutinin (A/PR/8/34) and orally delivered a low dose of rBVs to evaluate its vaccine efficacy in mice. Intranasal rBV vaccination was included in the whole experiment for comparison. We found that oral vaccination elicited high levels of virus-specific IgG and IgA antibody responses in both serum and mucosal samples (lung, tracheal, intestinal, fecal and vaginal). Surprisingly, complete protection from the lethal influenza challenge was observed, as indicated by reductions in the virus titer, inflammatory cytokine production, body weight change, and enhanced survival. These results suggest that oral delivery of the influenza rBV vaccine induces mucosal and systemic immunity, which protect mice from the lethal influenza virus challenge. Oral delivery of baculovirus vaccines can be developed as an effective vaccination route. |
| doi_str_mv | 10.1371/journal.pone.0233520 |
| format | Article |
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In this study, we generated recombinant baculoviruses (rBVs) expressing influenza hemagglutinin (A/PR/8/34) and orally delivered a low dose of rBVs to evaluate its vaccine efficacy in mice. Intranasal rBV vaccination was included in the whole experiment for comparison. We found that oral vaccination elicited high levels of virus-specific IgG and IgA antibody responses in both serum and mucosal samples (lung, tracheal, intestinal, fecal and vaginal). Surprisingly, complete protection from the lethal influenza challenge was observed, as indicated by reductions in the virus titer, inflammatory cytokine production, body weight change, and enhanced survival. These results suggest that oral delivery of the influenza rBV vaccine induces mucosal and systemic immunity, which protect mice from the lethal influenza virus challenge. Oral delivery of baculovirus vaccines can be developed as an effective vaccination route.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0233520</identifier><identifier>PMID: 32459823</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibodies ; Antigens ; B cells ; Baculovirus ; Baculoviruses ; Biology and Life Sciences ; Body weight ; Cytokines ; DNA vaccines ; Dosage and administration ; Drug delivery systems ; Health aspects ; Hemagglutinins ; Immunization ; Immunoglobulin A ; Immunoglobulin G ; Inflammation ; Influenza ; Influenza vaccines ; Influenza viruses ; Intestine ; Lectins ; Medical research ; Medicine and Health Sciences ; Mucosa ; Mucosal immunity ; Oral administration ; Respiratory system ; Vaccination ; Vaccine efficacy ; Vaccines ; Vagina ; Viruses ; Zoology</subject><ispartof>PloS one, 2020-05, Vol.15 (5), p.e0233520-e0233520</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Basak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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In this study, we generated recombinant baculoviruses (rBVs) expressing influenza hemagglutinin (A/PR/8/34) and orally delivered a low dose of rBVs to evaluate its vaccine efficacy in mice. Intranasal rBV vaccination was included in the whole experiment for comparison. We found that oral vaccination elicited high levels of virus-specific IgG and IgA antibody responses in both serum and mucosal samples (lung, tracheal, intestinal, fecal and vaginal). Surprisingly, complete protection from the lethal influenza challenge was observed, as indicated by reductions in the virus titer, inflammatory cytokine production, body weight change, and enhanced survival. These results suggest that oral delivery of the influenza rBV vaccine induces mucosal and systemic immunity, which protect mice from the lethal influenza virus challenge. 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delivery through the oral route remains the most convenient and safest way for mass immunization purposes, this method is limited by the requirement for large antigen doses and low vaccine efficacy. In this study, we generated recombinant baculoviruses (rBVs) expressing influenza hemagglutinin (A/PR/8/34) and orally delivered a low dose of rBVs to evaluate its vaccine efficacy in mice. Intranasal rBV vaccination was included in the whole experiment for comparison. We found that oral vaccination elicited high levels of virus-specific IgG and IgA antibody responses in both serum and mucosal samples (lung, tracheal, intestinal, fecal and vaginal). Surprisingly, complete protection from the lethal influenza challenge was observed, as indicated by reductions in the virus titer, inflammatory cytokine production, body weight change, and enhanced survival. These results suggest that oral delivery of the influenza rBV vaccine induces mucosal and systemic immunity, which protect mice from the lethal influenza virus challenge. Oral delivery of baculovirus vaccines can be developed as an effective vaccination route.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32459823</pmid><doi>10.1371/journal.pone.0233520</doi><tpages>e0233520</tpages><orcidid>https://orcid.org/0000-0003-0419-9339</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Antigens B cells Baculovirus Baculoviruses Biology and Life Sciences Body weight Cytokines DNA vaccines Dosage and administration Drug delivery systems Health aspects Hemagglutinins Immunization Immunoglobulin A Immunoglobulin G Inflammation Influenza Influenza vaccines Influenza viruses Intestine Lectins Medical research Medicine and Health Sciences Mucosa Mucosal immunity Oral administration Respiratory system Vaccination Vaccine efficacy Vaccines Vagina Viruses Zoology |
| title | Influenza vaccine efficacy induced by orally administered recombinant baculoviruses |
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