Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP
The purpose of this paper is to characterize the skin deterministic damage due to the effect of proton beam irradiation in mice occurred during a long-term observational experiment. This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal par...
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| creator | Pisciotta, Pietro Costantino, Angelita Cammarata, Francesco Paolo Torrisi, Filippo Calabrese, Giovanna Marchese, Valentina Cirrone, Giuseppe Antonio Pablo Petringa, Giada Forte, Giusi Irma Minafra, Luigi Bravatà, Valentina Gulisano, Massimo Scopelliti, Fabrizio Tommasino, Francesco Scifoni, Emanuele Cuttone, Giacomo Ippolito, Massimo Parenti, Rosalba Russo, Giorgio |
| description | The purpose of this paper is to characterize the skin deterministic damage due to the effect of proton beam irradiation in mice occurred during a long-term observational experiment. This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal part of a Spread-out Bragg peak (SOBP). To the best of our knowledge, no study has been conducted highlighting high grades of skin injury at the dose used in this paper. Nevertheless these effects occurred. In this regard, the experimental evidence of significant insurgence of skin injury induced by protons using a SOBP configuration will be shown. Skin damages were classified into six scores (from 0 to 5) according to the severity of the injuries and correlated to ED50 (i.e. the radiation dose at which 50% of animals show a specific score) at 40 days post-irradiation (d.p.i.). The effects of radiation on the overall animal wellbeing have been also monitored and the severity of radiation-induced skin injuries was observed and quantified up to 40 d.p.i. |
| doi_str_mv | 10.1371/journal.pone.0233258 |
| format | Article |
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This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal part of a Spread-out Bragg peak (SOBP). To the best of our knowledge, no study has been conducted highlighting high grades of skin injury at the dose used in this paper. Nevertheless these effects occurred. In this regard, the experimental evidence of significant insurgence of skin injury induced by protons using a SOBP configuration will be shown. Skin damages were classified into six scores (from 0 to 5) according to the severity of the injuries and correlated to ED50 (i.e. the radiation dose at which 50% of animals show a specific score) at 40 days post-irradiation (d.p.i.). The effects of radiation on the overall animal wellbeing have been also monitored and the severity of radiation-induced skin injuries was observed and quantified up to 40 d.p.i.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0233258</identifier><identifier>PMID: 32442228</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal experimentation ; Animal models ; Biology and Life Sciences ; Bragg curve ; Central nervous system diseases ; Complications and side effects ; Diagnosis ; Drug dosages ; Evaluation ; Injuries ; Irradiation ; Laboratory animals ; Medical research ; Medicine and Health Sciences ; Nuclear medicine ; Nuclear physics ; Observational studies ; Physical Sciences ; Physiology ; Post-irradiation ; Proton beam radiotherapy ; Proton beams ; Protons ; Radiation ; Radiation (Physics) ; Radiation damage ; Radiation dosage ; Radiation effects ; Radiation injuries ; Research and Analysis Methods ; Skin ; Skin injuries ; Skin manifestations ; Spinal cord ; Studies</subject><ispartof>PloS one, 2020-05, Vol.15 (5), p.e0233258</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Pisciotta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal part of a Spread-out Bragg peak (SOBP). To the best of our knowledge, no study has been conducted highlighting high grades of skin injury at the dose used in this paper. Nevertheless these effects occurred. In this regard, the experimental evidence of significant insurgence of skin injury induced by protons using a SOBP configuration will be shown. Skin damages were classified into six scores (from 0 to 5) according to the severity of the injuries and correlated to ED50 (i.e. the radiation dose at which 50% of animals show a specific score) at 40 days post-irradiation (d.p.i.). 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This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal part of a Spread-out Bragg peak (SOBP). To the best of our knowledge, no study has been conducted highlighting high grades of skin injury at the dose used in this paper. Nevertheless these effects occurred. In this regard, the experimental evidence of significant insurgence of skin injury induced by protons using a SOBP configuration will be shown. Skin damages were classified into six scores (from 0 to 5) according to the severity of the injuries and correlated to ED50 (i.e. the radiation dose at which 50% of animals show a specific score) at 40 days post-irradiation (d.p.i.). The effects of radiation on the overall animal wellbeing have been also monitored and the severity of radiation-induced skin injuries was observed and quantified up to 40 d.p.i.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32442228</pmid><doi>10.1371/journal.pone.0233258</doi><orcidid>https://orcid.org/0000-0002-5076-9796</orcidid><orcidid>https://orcid.org/0000-0003-1937-5403</orcidid><orcidid>https://orcid.org/0000-0001-8654-1745</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-05, Vol.15 (5), p.e0233258 |
| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Animal experimentation Animal models Biology and Life Sciences Bragg curve Central nervous system diseases Complications and side effects Diagnosis Drug dosages Evaluation Injuries Irradiation Laboratory animals Medical research Medicine and Health Sciences Nuclear medicine Nuclear physics Observational studies Physical Sciences Physiology Post-irradiation Proton beam radiotherapy Proton beams Protons Radiation Radiation (Physics) Radiation damage Radiation dosage Radiation effects Radiation injuries Research and Analysis Methods Skin Skin injuries Skin manifestations Spinal cord Studies |
| title | Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T09%3A52%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20proton%20beam%20radiation-induced%20skin%20injury%20in%20a%20murine%20model%20using%20a%20clinical%20SOBP&rft.jtitle=PloS%20one&rft.au=Pisciotta,%20Pietro&rft.date=2020-05-22&rft.volume=15&rft.issue=5&rft.spage=e0233258&rft.pages=e0233258-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0233258&rft_dat=%3Cgale_plos_%3EA624652714%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2405841538&rft_id=info:pmid/32442228&rft_galeid=A624652714&rft_doaj_id=oai_doaj_org_article_3493d2b737c94038a4deae128014d22e&rfr_iscdi=true |