Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex

The contribution of astrocytes to the BOLD fMRI and DfMRI responses in visual cortex of mice following visual stimulation was investigated using TGN-020, an aquaporin 4 (AQP4) channel blocker, acting as an astrocyte function perturbator. Under TGN-020 injection the amplitude of the BOLD fMRI respons...

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Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0228759-e0228759
Hauptverfasser:	Komaki, Yuji, Debacker, Clement, Djemai, Boucif, Ciobanu, Luisa, Tsurugizawa, Tomokazu, Bihan, Denis Le
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Aquaporin 4 Aquaporins Astrocytes Biology and Life Sciences Body temperature Diagnostic imaging Engineering and Technology Functional magnetic resonance imaging Generalized linear models Laboratory animals Magnetic resonance imaging Medicine and Health Sciences Perturbation Physiological aspects Research and Analysis Methods Social Sciences Time Visual cortex Visual stimuli
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