Naringenin mitigates autoimmune features in lupus-prone mice by modulation of T-cell subsets and cytokines profile

Naringenin is flavonoid mainly found in citrus fruits which has shown several biological properties. In this work, we evaluated the therapeutic potential of the flavonoid Naringenin. Five-month-old B6.MRL-Faslpr/J lupus-prone mice were administered daily orally with Naringenin for seven months. We s...

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Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0233138-e0233138
Hauptverfasser:	Abrego-Peredo, Amayrani, Romero-Ramírez, Héctor, Espinosa, Enrique, López-Herrera, Gabriela, García-García, Fabio, Flores-Muñoz, Mónica, Sandoval-Montes, Claudia, Rodríguez-Alba, Juan Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-DNA antibodies Antibodies Autoantibodies Autoimmunity B cells Biological properties Biology and Life Sciences Care and treatment Cellulose Citrus Citrus fruits Cyclophosphamide Cytokines Damage prevention Effector cells Fibrosis Flavonoids Fruits Health aspects Immunological memory Immunology Immunoregulation Interleukin 10 Interleukin 6 Kidneys Laboratories Lupus Lymphocytes Lymphocytes T Medicine and Health Sciences Memory cells Modulation Naringenin Oral administration Serum levels Spleen Splenomegaly Systemic lupus erythematosus T cells Testing Tumor necrosis factor Tumor necrosis factor-α γ-Interferon
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