Analytical performance of thrombospondin-1 and cathepsin D immunoassays part of a novel CE-IVD marked test as an aid in the diagnosis of prostate cancer

The Prostate Specific Antigen (PSA) test suffers from low specificity for the diagnosis of Prostate Cancer (PCa). We originally discovered two cancer-related proteins thrombospondin-1 (THBS1) and cathepsin D (CTSD) using a mass-spectrometry-based proteomics approach. The two serum proteins were show...

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Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0233442
Hauptverfasser:	Macagno, Annalisa, Athanasiou, Alcibiade, Wittig, Anja, Huber, Ramy, Weber, Stephan, Keller, Thomas, Rhiel, Martin, Golding, Bruno, Schiess, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibodies Antigens Biology and Life Sciences Biomarkers Biopsy Blood levels Blood proteins Blood Specimen Collection - methods Cancer diagnosis Cathepsin D Cathepsin D - blood Centrifugal force Centrifugation Coefficient of variation Diagnosis Diagnostic systems Enzyme-Linked Immunosorbent Assay Humans Immunoassay Immunoassays In vitro methods and tests Laboratories Linearity Male Mathematical analysis Medical diagnosis Medical tests Medicine and Health Sciences Methods Novels Observer Variation Prostate cancer Prostate specific antigen Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Protein Stability Proteins Proteomics Proteomics - methods Reproducibility of Results Research and Analysis Methods Room temperature Sample preparation Serum proteins Spectrometry Spectroscopy Stability analysis Testing Thrombospondin Thrombospondin 1 - blood Tubes Tumor proteins
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