Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication

Viruses are known for their extremely compact genomes composed almost entirely of protein-coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) are encoded by human cytomegalovirus (HCMV). Although these RNAs accumulate to high levels during lytic infection, their functions remain largely un...

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Veröffentlicht in:	PLoS pathogens 2020-04, Vol.16 (4), p.e1008390-e1008390
Hauptverfasser:	Tai-Schmiedel, Julie, Karniely, Sharon, Lau, Betty, Ezra, Adi, Eliyahu, Erez, Nachshon, Aharon, Kerr, Karen, Suárez, Nicolás, Schwartz, Michal, Davison, Andrew J, Stern-Ginossar, Noam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding proteins Biology and life sciences Cells, Cultured CRISPR Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - genetics Cytomegalovirus Infections - microbiology Cytomegalovirus Infections - pathology Deoxyribonucleic acid Depletion DNA DNA biosynthesis DNA polymerase DNA Replication DNA viruses DNA, Viral - genetics DNA-binding protein Fibroblasts Gene expression Gene Expression Regulation, Viral Genes Genomes Genomics Health aspects Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Infection Infections Localization Medicine and Health Sciences Mice Protein binding Proteins Replication Replication initiation Replication Origin Replication origins Research and analysis methods Ribonucleic acid RNA RNA, Long Noncoding - genetics Single-stranded DNA Single-stranded DNA-binding protein Viral Proteins - genetics Virus Replication Viruses
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