A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract

Within the human respiratory tract (HRT), virus diffuses through the periciliary fluid (PCF) bathing the epithelium. But virus also undergoes advection: as the mucus layer sitting atop the PCF is pushed along by the ciliated cell's beating cilia, the PCF and its virus content are also pushed al...

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Veröffentlicht in:	PLoS computational biology 2020-04, Vol.16 (4), p.e1007705-e1007705
Hauptverfasser:	Quirouette, Christian, Younis, Nada P, Reddy, Micaela B, Beauchemin, Catherine A A
Format:	Artikel
Sprache:	eng
Schlagworte:	Advection Antiviral agents Bathing Biology and life sciences Cilia Development and progression Diagnosis Diffusion Distribution Epithelium Humans Immune response Infections Influenza Influenza A Influenza A virus - pathogenicity Influenza research Influenza viruses Influenza, Human - epidemiology Influenza, Human - metabolism Influenza, Human - virology Kinetics Localization Mathematical models Medicine and health sciences Models, Theoretical Mucus Nose Ordinary differential equations Orthomyxoviridae Infections - virology Partial differential equations Physical Sciences Physics Regeneration Respiratory System - virology Respiratory tract Respiratory tract infections Software Virus Replication Viruses
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