Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes

Lymph nodes (LNs) are highly organized secondary lymphoid organs that mediate adaptive immune responses to antigens delivered via afferent lymphatic vessels. Lymphatic endothelial cells (LECs) line intranodal lymphatic sinuses and organize lymph and antigen distribution. LECs also directly regulate...

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Veröffentlicht in:	PLoS biology 2020-04, Vol.18 (4), p.e3000704-e3000704
Hauptverfasser:	Fujimoto, Noriki, He, Yuliang, D'Addio, Marco, Tacconi, Carlotta, Detmar, Michael, Dieterich, Lothar C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Antigens Autoantigens Biology and Life Sciences Cell adhesion & migration Cell research Cellular control mechanisms Composition Egress Endothelial cells Endothelium Gene expression Gene sequencing Health aspects Heterogeneity Immune response Immunological tolerance Kinases Low density lipoprotein Lymph nodes Lymphatic system Lymphocytes Lymphocytes T Mapping Markers Medical examination Medicine and Health Sciences Metastases Methods and Resources Organs Pharmaceutical sciences Research and Analysis Methods Ribonucleic acid RNA Scavenging Sensory neurons Sinuses Subpopulations
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