High-dimensional mediation analysis in survival models

Mediation analysis with high-dimensional DNA methylation markers is important in identifying epigenetic pathways between environmental exposures and health outcomes. There have been some methodology developments of mediation analysis with high-dimensional mediators. However, high-dimensional mediati...

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Veröffentlicht in:	PLoS computational biology 2020-04, Vol.16 (4), p.e1007768
Hauptverfasser:	Luo, Chengwen, Fa, Botao, Yan, Yuting, Wang, Yang, Zhou, Yiwang, Zhang, Yue, Yu, Zhangsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Bioinformatics Biology and life sciences Biomarkers Biotechnology Computational Biology - methods Computer simulation CpG islands Deoxyribonucleic acid Dimensional analysis DNA DNA methylation DNA Methylation - genetics Epigenetics Epigenomics Health hazards Health risks Humans Life sciences Lung cancer Lung Neoplasms - genetics Lung Neoplasms - mortality Mediating effects (Research) Mediation Medicine and Health Sciences Methods Middle Aged Minimax technique Models, Statistical Patient outcomes Performance evaluation Research and Analysis Methods Simulation Smoking Smoking - genetics Smoking - mortality Social Sciences Statistical models Survival Survival Analysis
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