The emerging risk of oropharyngeal and oral cavity cancer in HPV-related subsites in young people in Brazil
Human papillomavirus (HPV) is responsible for the rise in the incidence of cancer in the oropharynx, tonsils, and base of the tongue (i.e., HPV-related subsites). HPV triggered the changes in the epidemiology of oropharyngeal and oral cavity cancer (OPC/OCC) in Asia, Europe, North America, and Ocean...
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| description | Human papillomavirus (HPV) is responsible for the rise in the incidence of cancer in the oropharynx, tonsils, and base of the tongue (i.e., HPV-related subsites). HPV triggered the changes in the epidemiology of oropharyngeal and oral cavity cancer (OPC/OCC) in Asia, Europe, North America, and Oceania. Hence, the incidence of cancer in HPV-related subsites is augmenting, while that in other HPV-unrelated subsites is decreasing. In South America, although the incidence of HPV-positive tumors has gradually increased, there is an atypically low prevalence of HPV in people with OPC/OCC. To clarify whether this dramatic shift in incidence trends also occurred in this population, we estimated the burden of HPV on the incidence trends of OPCs/OCCs in São Paulo city in Brazil. In this population-based study, we categorized OPCs/OCCs by HPV-related and HPV-unrelated subsites. We used Poisson regression to assess the age-standardized incidence rates (ASRs) stratified by sex and age groups, as well as to examine the age-period-cohort effects. There were 15,391 cases of OPCs/OCCs diagnosed in HPV-related (n = 5,898; 38.3%) and HPV-unrelated (n = 9,493; 61.7%) subsites. Overall, the ASRs decreased for most subsites, for both sexes and for all age groups, except for HPV-related OPC/OCC in young males and females, which increased by 3.8% and 8.6% per year, respectively. In the birth-cohort-effect analysis, we identified an increasing risk for HPV-related OPC/OCC in both sexes in recent birth cohorts; however, this risk was sharply decreased in HPV-unrelated subsites. Our data demonstrate an emerging risk for HPV-related OPC/OCC in young people, which supports prophylactic HPV vaccination in this group. |
| doi_str_mv | 10.1371/journal.pone.0232871 |
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HPV triggered the changes in the epidemiology of oropharyngeal and oral cavity cancer (OPC/OCC) in Asia, Europe, North America, and Oceania. Hence, the incidence of cancer in HPV-related subsites is augmenting, while that in other HPV-unrelated subsites is decreasing. In South America, although the incidence of HPV-positive tumors has gradually increased, there is an atypically low prevalence of HPV in people with OPC/OCC. To clarify whether this dramatic shift in incidence trends also occurred in this population, we estimated the burden of HPV on the incidence trends of OPCs/OCCs in São Paulo city in Brazil. In this population-based study, we categorized OPCs/OCCs by HPV-related and HPV-unrelated subsites. We used Poisson regression to assess the age-standardized incidence rates (ASRs) stratified by sex and age groups, as well as to examine the age-period-cohort effects. There were 15,391 cases of OPCs/OCCs diagnosed in HPV-related (n = 5,898; 38.3%) and HPV-unrelated (n = 9,493; 61.7%) subsites. Overall, the ASRs decreased for most subsites, for both sexes and for all age groups, except for HPV-related OPC/OCC in young males and females, which increased by 3.8% and 8.6% per year, respectively. In the birth-cohort-effect analysis, we identified an increasing risk for HPV-related OPC/OCC in both sexes in recent birth cohorts; however, this risk was sharply decreased in HPV-unrelated subsites. Our data demonstrate an emerging risk for HPV-related OPC/OCC in young people, which supports prophylactic HPV vaccination in this group.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0232871</identifier><identifier>PMID: 32407339</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Age groups ; Biology and life sciences ; Birth ; Cancer ; Cohort analysis ; Complications and side effects ; Demographic aspects ; Epidemiology ; Health aspects ; Health education ; Human papillomavirus ; Hypotheses ; Males ; Medicine and Health Sciences ; Mouth cancer ; Oral cancer ; Oral cavity ; Oropharynx ; Papillomavirus ; Papillomavirus infections ; People and Places ; Pharyngeal cancer ; Physical Sciences ; Population ; Population studies ; Public health ; Regression analysis ; Research and Analysis Methods ; Risk ; Risk factors ; Sexes ; Throat cancer ; Trends ; Tumors ; Vaccination ; Young adults ; Youth</subject><ispartof>PloS one, 2020-05, Vol.15 (5), p.e0232871-e0232871</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Menezes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Natasha</au><au>Liu, Xuefeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The emerging risk of oropharyngeal and oral cavity cancer in HPV-related subsites in young people in Brazil</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-05-14</date><risdate>2020</risdate><volume>15</volume><issue>5</issue><spage>e0232871</spage><epage>e0232871</epage><pages>e0232871-e0232871</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Human papillomavirus (HPV) is responsible for the rise in the incidence of cancer in the oropharynx, tonsils, and base of the tongue (i.e., HPV-related subsites). HPV triggered the changes in the epidemiology of oropharyngeal and oral cavity cancer (OPC/OCC) in Asia, Europe, North America, and Oceania. Hence, the incidence of cancer in HPV-related subsites is augmenting, while that in other HPV-unrelated subsites is decreasing. In South America, although the incidence of HPV-positive tumors has gradually increased, there is an atypically low prevalence of HPV in people with OPC/OCC. To clarify whether this dramatic shift in incidence trends also occurred in this population, we estimated the burden of HPV on the incidence trends of OPCs/OCCs in São Paulo city in Brazil. In this population-based study, we categorized OPCs/OCCs by HPV-related and HPV-unrelated subsites. We used Poisson regression to assess the age-standardized incidence rates (ASRs) stratified by sex and age groups, as well as to examine the age-period-cohort effects. There were 15,391 cases of OPCs/OCCs diagnosed in HPV-related (n = 5,898; 38.3%) and HPV-unrelated (n = 9,493; 61.7%) subsites. Overall, the ASRs decreased for most subsites, for both sexes and for all age groups, except for HPV-related OPC/OCC in young males and females, which increased by 3.8% and 8.6% per year, respectively. In the birth-cohort-effect analysis, we identified an increasing risk for HPV-related OPC/OCC in both sexes in recent birth cohorts; however, this risk was sharply decreased in HPV-unrelated subsites. Our data demonstrate an emerging risk for HPV-related OPC/OCC in young people, which supports prophylactic HPV vaccination in this group.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32407339</pmid><doi>10.1371/journal.pone.0232871</doi><tpages>e0232871</tpages><orcidid>https://orcid.org/0000-0001-9230-1879</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Age groups Biology and life sciences Birth Cancer Cohort analysis Complications and side effects Demographic aspects Epidemiology Health aspects Health education Human papillomavirus Hypotheses Males Medicine and Health Sciences Mouth cancer Oral cancer Oral cavity Oropharynx Papillomavirus Papillomavirus infections People and Places Pharyngeal cancer Physical Sciences Population Population studies Public health Regression analysis Research and Analysis Methods Risk Risk factors Sexes Throat cancer Trends Tumors Vaccination Young adults Youth |
| title | The emerging risk of oropharyngeal and oral cavity cancer in HPV-related subsites in young people in Brazil |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T01%3A16%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20emerging%20risk%20of%20oropharyngeal%20and%20oral%20cavity%20cancer%20in%20HPV-related%20subsites%20in%20young%20people%20in%20Brazil&rft.jtitle=PloS%20one&rft.au=Menezes,%20Fabr%C3%ADcio%20Dos%20Santos&rft.date=2020-05-14&rft.volume=15&rft.issue=5&rft.spage=e0232871&rft.epage=e0232871&rft.pages=e0232871-e0232871&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0232871&rft_dat=%3Cgale_plos_%3EA623857408%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2403021882&rft_id=info:pmid/32407339&rft_galeid=A623857408&rft_doaj_id=oai_doaj_org_article_8c25e5b13b2e4eaabecb644e9f2121bc&rfr_iscdi=true |