Retention of patients in opioid substitution treatment: A systematic review
Retention in opioid substitution (OST) treatment is associated with substantial reductions in all cause and overdose mortality. This systematic review aims to identify both protective factors supporting retention in OST, and risk factors for treatment dropout. A systematic search was performed using...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-05, Vol.15 (5), p.e0232086-e0232086 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0232086 |
|---|---|
| container_issue | 5 |
| container_start_page | e0232086 |
| container_title | PloS one |
| container_volume | 15 |
| creator | O'Connor, Aisling Máire Cousins, Gráinne Durand, Louise Barry, Joe Boland, Fiona |
| description | Retention in opioid substitution (OST) treatment is associated with substantial reductions in all cause and overdose mortality. This systematic review aims to identify both protective factors supporting retention in OST, and risk factors for treatment dropout.
A systematic search was performed using MEDLINE, Embase, PsycInfo, CINAHL and Web of Science (January 2001 to October 2019). Randomised controlled trials (RCTs) and observational cohort studies reporting on retention rates and factors associated with retention in OST were included. Factors associated with treatment retention and dropout were explored according to the Maudsley Addiction Profile. A narrative synthesis is provided.
67 studies were included in this review (4 RCTs and 63 observational cohort studies; N = 294,592), all assessing factors associated with retention in OST or treatment dropout. The median retention rate across observational studies was approximately 57% at 12 months, which fell to 38.4% at three years. Studies included were heterogeneous in nature with respect to treatment setting, type of OST, risk factor assessment, ascertainment of outcome and duration of follow-up. While the presence of such methodological heterogeneity makes it difficult to synthesise results, there is limited evidence to support the influence of a number of factors on retention, including age, substance use, OST drug dose, legal issues, and attitudes to OST.
Younger age, substance use particularly cocaine and heroin use, lower doses of methadone, criminal activity/incarceration, and negative attitudes to MMT appear to be associated with reduced retention in OST. A consensus definition of retention is required to allow for comparability across future studies. |
| doi_str_mv | 10.1371/journal.pone.0232086 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2403017371</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A623857379</galeid><doaj_id>oai_doaj_org_article_5d7adf324cd747988ea35927fe0ea29e</doaj_id><sourcerecordid>A623857379</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-840c81e6a7d25d8d8e47cafcaf530d24a50d42ad3541825972a0648b8d2ac5463</originalsourceid><addsrcrecordid>eNqNkl2L1DAUhoso7rr6D0QLgujFjGk-2tQLYVj8GFxYWD9uQyY5ncnQNrVJV_ffe2amu0xlLySBJunznpxz8ibJ84zMM1Zk77Z-6FtdzzvfwpxQRonMHySnWcnoLKeEPTxanyRPQtgSIpjM88fJCaOcFIxmp8nXK4jQRufb1Fdpp6PDXUgdbjvnnU3DsArRxWGPxB50bJB4ny7ScBMiNKgwaQ_XDn4_TR5Vug7wbPyeJT8-ffx-_mV2cfl5eb64mJm8pHEmOTEyg1wXlgorrQReGF3hFIxYyrUgllNtmeCZpKIsqCY5lytpqTaC5-wseXmI29U-qLEPQWFNjGQF9gaJ5YGwXm9V17tG9zfKa6f2B75fK91j4jUoYQttK2yIsQUvSilBM1HSogICmpaAsT6Mtw2rBqzB6ntdT4JO_7Ruo9b-WhWUcpHtknkzBuj9rwFCVI0LBupat-CHfd448pJxRF_9g95f3UitNRbg2srjvWYXVC1yyqRAqkRqfg-Fw0LjDJqmcng-EbydCJCJ8Ceu9RCCWn67-n_28ueUfX3EbkDXcRN8vXdUmIL8AJreh9BDddfkjKid52-7oXaeV6PnUfbi-IHuRLcmZ38BQvb7uQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2403017371</pqid></control><display><type>article</type><title>Retention of patients in opioid substitution treatment: A systematic review</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>O'Connor, Aisling Máire ; Cousins, Gráinne ; Durand, Louise ; Barry, Joe ; Boland, Fiona</creator><contributor>Latkin, Carl A.</contributor><creatorcontrib>O'Connor, Aisling Máire ; Cousins, Gráinne ; Durand, Louise ; Barry, Joe ; Boland, Fiona ; Latkin, Carl A.</creatorcontrib><description>Retention in opioid substitution (OST) treatment is associated with substantial reductions in all cause and overdose mortality. This systematic review aims to identify both protective factors supporting retention in OST, and risk factors for treatment dropout.
A systematic search was performed using MEDLINE, Embase, PsycInfo, CINAHL and Web of Science (January 2001 to October 2019). Randomised controlled trials (RCTs) and observational cohort studies reporting on retention rates and factors associated with retention in OST were included. Factors associated with treatment retention and dropout were explored according to the Maudsley Addiction Profile. A narrative synthesis is provided.
67 studies were included in this review (4 RCTs and 63 observational cohort studies; N = 294,592), all assessing factors associated with retention in OST or treatment dropout. The median retention rate across observational studies was approximately 57% at 12 months, which fell to 38.4% at three years. Studies included were heterogeneous in nature with respect to treatment setting, type of OST, risk factor assessment, ascertainment of outcome and duration of follow-up. While the presence of such methodological heterogeneity makes it difficult to synthesise results, there is limited evidence to support the influence of a number of factors on retention, including age, substance use, OST drug dose, legal issues, and attitudes to OST.
Younger age, substance use particularly cocaine and heroin use, lower doses of methadone, criminal activity/incarceration, and negative attitudes to MMT appear to be associated with reduced retention in OST. A consensus definition of retention is required to allow for comparability across future studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0232086</identifier><identifier>PMID: 32407321</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Addictions ; Attitudes ; Bias ; Biology and Life Sciences ; Clinical trials ; Cocaine ; Crime ; Drug abuse ; Drug overdose ; Drug therapy ; Future predictions ; Health risks ; Heroin ; Heterogeneity ; Legal issues ; Management ; Medicine and Health Sciences ; Methadone ; Methadone maintenance ; Mortality ; Narcotics ; Narratives ; Nature ; Observational studies ; Opioid abuse ; Opioids ; Overdose ; Patient compliance ; Patient outcomes ; Physical Sciences ; Research and Analysis Methods ; Retention ; Risk analysis ; Risk factors ; Setting (Literature) ; Social Sciences ; Studies ; Substance abuse ; Substance abuse treatment ; Substance use ; Substitutes</subject><ispartof>PloS one, 2020-05, Vol.15 (5), p.e0232086-e0232086</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 O’Connor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 O’Connor et al 2020 O’Connor et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-840c81e6a7d25d8d8e47cafcaf530d24a50d42ad3541825972a0648b8d2ac5463</citedby><cites>FETCH-LOGICAL-c692t-840c81e6a7d25d8d8e47cafcaf530d24a50d42ad3541825972a0648b8d2ac5463</cites><orcidid>0000-0002-1574-6732 ; 0000-0003-3228-0046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224511/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224511/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32407321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Latkin, Carl A.</contributor><creatorcontrib>O'Connor, Aisling Máire</creatorcontrib><creatorcontrib>Cousins, Gráinne</creatorcontrib><creatorcontrib>Durand, Louise</creatorcontrib><creatorcontrib>Barry, Joe</creatorcontrib><creatorcontrib>Boland, Fiona</creatorcontrib><title>Retention of patients in opioid substitution treatment: A systematic review</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Retention in opioid substitution (OST) treatment is associated with substantial reductions in all cause and overdose mortality. This systematic review aims to identify both protective factors supporting retention in OST, and risk factors for treatment dropout.
A systematic search was performed using MEDLINE, Embase, PsycInfo, CINAHL and Web of Science (January 2001 to October 2019). Randomised controlled trials (RCTs) and observational cohort studies reporting on retention rates and factors associated with retention in OST were included. Factors associated with treatment retention and dropout were explored according to the Maudsley Addiction Profile. A narrative synthesis is provided.
67 studies were included in this review (4 RCTs and 63 observational cohort studies; N = 294,592), all assessing factors associated with retention in OST or treatment dropout. The median retention rate across observational studies was approximately 57% at 12 months, which fell to 38.4% at three years. Studies included were heterogeneous in nature with respect to treatment setting, type of OST, risk factor assessment, ascertainment of outcome and duration of follow-up. While the presence of such methodological heterogeneity makes it difficult to synthesise results, there is limited evidence to support the influence of a number of factors on retention, including age, substance use, OST drug dose, legal issues, and attitudes to OST.
Younger age, substance use particularly cocaine and heroin use, lower doses of methadone, criminal activity/incarceration, and negative attitudes to MMT appear to be associated with reduced retention in OST. A consensus definition of retention is required to allow for comparability across future studies.</description><subject>Addictions</subject><subject>Attitudes</subject><subject>Bias</subject><subject>Biology and Life Sciences</subject><subject>Clinical trials</subject><subject>Cocaine</subject><subject>Crime</subject><subject>Drug abuse</subject><subject>Drug overdose</subject><subject>Drug therapy</subject><subject>Future predictions</subject><subject>Health risks</subject><subject>Heroin</subject><subject>Heterogeneity</subject><subject>Legal issues</subject><subject>Management</subject><subject>Medicine and Health Sciences</subject><subject>Methadone</subject><subject>Methadone maintenance</subject><subject>Mortality</subject><subject>Narcotics</subject><subject>Narratives</subject><subject>Nature</subject><subject>Observational studies</subject><subject>Opioid abuse</subject><subject>Opioids</subject><subject>Overdose</subject><subject>Patient compliance</subject><subject>Patient outcomes</subject><subject>Physical Sciences</subject><subject>Research and Analysis Methods</subject><subject>Retention</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Setting (Literature)</subject><subject>Social Sciences</subject><subject>Studies</subject><subject>Substance abuse</subject><subject>Substance abuse treatment</subject><subject>Substance use</subject><subject>Substitutes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLgujFjGk-2tQLYVj8GFxYWD9uQyY5ncnQNrVJV_ffe2amu0xlLySBJunznpxz8ibJ84zMM1Zk77Z-6FtdzzvfwpxQRonMHySnWcnoLKeEPTxanyRPQtgSIpjM88fJCaOcFIxmp8nXK4jQRufb1Fdpp6PDXUgdbjvnnU3DsArRxWGPxB50bJB4ny7ScBMiNKgwaQ_XDn4_TR5Vug7wbPyeJT8-ffx-_mV2cfl5eb64mJm8pHEmOTEyg1wXlgorrQReGF3hFIxYyrUgllNtmeCZpKIsqCY5lytpqTaC5-wseXmI29U-qLEPQWFNjGQF9gaJ5YGwXm9V17tG9zfKa6f2B75fK91j4jUoYQttK2yIsQUvSilBM1HSogICmpaAsT6Mtw2rBqzB6ntdT4JO_7Ruo9b-WhWUcpHtknkzBuj9rwFCVI0LBupat-CHfd448pJxRF_9g95f3UitNRbg2srjvWYXVC1yyqRAqkRqfg-Fw0LjDJqmcng-EbydCJCJ8Ceu9RCCWn67-n_28ueUfX3EbkDXcRN8vXdUmIL8AJreh9BDddfkjKid52-7oXaeV6PnUfbi-IHuRLcmZ38BQvb7uQ</recordid><startdate>20200514</startdate><enddate>20200514</enddate><creator>O'Connor, Aisling Máire</creator><creator>Cousins, Gráinne</creator><creator>Durand, Louise</creator><creator>Barry, Joe</creator><creator>Boland, Fiona</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1574-6732</orcidid><orcidid>https://orcid.org/0000-0003-3228-0046</orcidid></search><sort><creationdate>20200514</creationdate><title>Retention of patients in opioid substitution treatment: A systematic review</title><author>O'Connor, Aisling Máire ; Cousins, Gráinne ; Durand, Louise ; Barry, Joe ; Boland, Fiona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-840c81e6a7d25d8d8e47cafcaf530d24a50d42ad3541825972a0648b8d2ac5463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Addictions</topic><topic>Attitudes</topic><topic>Bias</topic><topic>Biology and Life Sciences</topic><topic>Clinical trials</topic><topic>Cocaine</topic><topic>Crime</topic><topic>Drug abuse</topic><topic>Drug overdose</topic><topic>Drug therapy</topic><topic>Future predictions</topic><topic>Health risks</topic><topic>Heroin</topic><topic>Heterogeneity</topic><topic>Legal issues</topic><topic>Management</topic><topic>Medicine and Health Sciences</topic><topic>Methadone</topic><topic>Methadone maintenance</topic><topic>Mortality</topic><topic>Narcotics</topic><topic>Narratives</topic><topic>Nature</topic><topic>Observational studies</topic><topic>Opioid abuse</topic><topic>Opioids</topic><topic>Overdose</topic><topic>Patient compliance</topic><topic>Patient outcomes</topic><topic>Physical Sciences</topic><topic>Research and Analysis Methods</topic><topic>Retention</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Setting (Literature)</topic><topic>Social Sciences</topic><topic>Studies</topic><topic>Substance abuse</topic><topic>Substance abuse treatment</topic><topic>Substance use</topic><topic>Substitutes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Connor, Aisling Máire</creatorcontrib><creatorcontrib>Cousins, Gráinne</creatorcontrib><creatorcontrib>Durand, Louise</creatorcontrib><creatorcontrib>Barry, Joe</creatorcontrib><creatorcontrib>Boland, Fiona</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Connor, Aisling Máire</au><au>Cousins, Gráinne</au><au>Durand, Louise</au><au>Barry, Joe</au><au>Boland, Fiona</au><au>Latkin, Carl A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retention of patients in opioid substitution treatment: A systematic review</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-05-14</date><risdate>2020</risdate><volume>15</volume><issue>5</issue><spage>e0232086</spage><epage>e0232086</epage><pages>e0232086-e0232086</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Retention in opioid substitution (OST) treatment is associated with substantial reductions in all cause and overdose mortality. This systematic review aims to identify both protective factors supporting retention in OST, and risk factors for treatment dropout.
A systematic search was performed using MEDLINE, Embase, PsycInfo, CINAHL and Web of Science (January 2001 to October 2019). Randomised controlled trials (RCTs) and observational cohort studies reporting on retention rates and factors associated with retention in OST were included. Factors associated with treatment retention and dropout were explored according to the Maudsley Addiction Profile. A narrative synthesis is provided.
67 studies were included in this review (4 RCTs and 63 observational cohort studies; N = 294,592), all assessing factors associated with retention in OST or treatment dropout. The median retention rate across observational studies was approximately 57% at 12 months, which fell to 38.4% at three years. Studies included were heterogeneous in nature with respect to treatment setting, type of OST, risk factor assessment, ascertainment of outcome and duration of follow-up. While the presence of such methodological heterogeneity makes it difficult to synthesise results, there is limited evidence to support the influence of a number of factors on retention, including age, substance use, OST drug dose, legal issues, and attitudes to OST.
Younger age, substance use particularly cocaine and heroin use, lower doses of methadone, criminal activity/incarceration, and negative attitudes to MMT appear to be associated with reduced retention in OST. A consensus definition of retention is required to allow for comparability across future studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32407321</pmid><doi>10.1371/journal.pone.0232086</doi><tpages>e0232086</tpages><orcidid>https://orcid.org/0000-0002-1574-6732</orcidid><orcidid>https://orcid.org/0000-0003-3228-0046</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-05, Vol.15 (5), p.e0232086-e0232086 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2403017371 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Addictions Attitudes Bias Biology and Life Sciences Clinical trials Cocaine Crime Drug abuse Drug overdose Drug therapy Future predictions Health risks Heroin Heterogeneity Legal issues Management Medicine and Health Sciences Methadone Methadone maintenance Mortality Narcotics Narratives Nature Observational studies Opioid abuse Opioids Overdose Patient compliance Patient outcomes Physical Sciences Research and Analysis Methods Retention Risk analysis Risk factors Setting (Literature) Social Sciences Studies Substance abuse Substance abuse treatment Substance use Substitutes |
| title | Retention of patients in opioid substitution treatment: A systematic review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T07%3A20%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retention%20of%20patients%20in%20opioid%20substitution%20treatment:%20A%20systematic%20review&rft.jtitle=PloS%20one&rft.au=O'Connor,%20Aisling%20M%C3%A1ire&rft.date=2020-05-14&rft.volume=15&rft.issue=5&rft.spage=e0232086&rft.epage=e0232086&rft.pages=e0232086-e0232086&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0232086&rft_dat=%3Cgale_plos_%3EA623857379%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2403017371&rft_id=info:pmid/32407321&rft_galeid=A623857379&rft_doaj_id=oai_doaj_org_article_5d7adf324cd747988ea35927fe0ea29e&rfr_iscdi=true |