Likely questionnaire-diagnosed food allergy in 78, 890 adults from the northern Netherlands
It is challenging to define likely food allergy (FA) in large populations which limited the number of large studies regarding risk factors for FA. We studied the prevalence and characteristics of self-reported FA (s-rFA) in the large, population-based Dutch Lifelines cohort and identified associated...
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| Veröffentlicht in: | PloS one 2020-05, Vol.15 (5), p.e0231818-e0231818 |
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| creator | Westerlaken-van Ginkel, Cornelia Doriene Vonk, Judith M Flokstra-de Blok, Bertine M J Sprikkelman, Aline B Koppelman, Gerard H Dubois, Anthony E J |
| description | It is challenging to define likely food allergy (FA) in large populations which limited the number of large studies regarding risk factors for FA.
We studied the prevalence and characteristics of self-reported FA (s-rFA) in the large, population-based Dutch Lifelines cohort and identified associated risk factors.
Likely food allergic cases (LikelyFA) were classified based on questionnaire reported characteristics consistent with FA. Subjects with atypical characteristics were classified as Indeterminate. We investigated 13 potential risk factors for LikelyFA such as birth mode and living on a farm and addressed health-related quality of life (H-RQOL).
Of the 78, 890 subjects, 12.1% had s-rFA of which 4.0% and 8.1% were classified as LikelyFA and Indeterminate, respectively. Younger age, female sex, asthma, eczema and nasal allergy increased the risk of LikelyFA (p-value range |
| doi_str_mv | 10.1371/journal.pone.0231818 |
| format | Article |
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We studied the prevalence and characteristics of self-reported FA (s-rFA) in the large, population-based Dutch Lifelines cohort and identified associated risk factors.
Likely food allergic cases (LikelyFA) were classified based on questionnaire reported characteristics consistent with FA. Subjects with atypical characteristics were classified as Indeterminate. We investigated 13 potential risk factors for LikelyFA such as birth mode and living on a farm and addressed health-related quality of life (H-RQOL).
Of the 78, 890 subjects, 12.1% had s-rFA of which 4.0% and 8.1% were classified as LikelyFA and Indeterminate, respectively. Younger age, female sex, asthma, eczema and nasal allergy increased the risk of LikelyFA (p-value range <1.00*10-250-1.29*10-7). Living in a small city/large village or suburb during childhood was associated with a higher risk of LikelyFA than living on a farm (p-value = 7.81*10-4 and p = 4.84*10-4, respectively). Subjects classified as Indeterminate more often reported depression and burn-out compared to those without FA (p-value = 1.46*10-4 and p = 8.39*10-13, respectively). No association was found with ethnicity, (duration of) breastfeeding, birth mode and reported eating disorder. Mental and physical component scores measuring H-RQOL were lower in both those classified as LikelyFA and Indeterminate compared to those without FA.
The prevalence of s-rFA among adults is considerable and one-third reports characteristics consistent with LikelyFA. Living on a farm decreased the risk of LikelyFA. The association of poorer H-RQOL as well as depression and burn-out with questionable self-perceived FA is striking and a priority for future study.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0231818</identifier><identifier>PMID: 32401757</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Allergies ; Allergy ; Asthma ; Biology and Life Sciences ; Birth ; Breast feeding ; Breastfeeding & lactation ; Childhood ; Children ; Classification ; Diagnosis ; Eating disorders ; Eczema ; Farms ; Food ; Food allergies ; Food hypersensitivity ; Health ; Health risks ; Health surveys ; Identification methods ; Medical research ; Medicine and Health Sciences ; Mental disorders ; Minority & ethnic groups ; Population ; Quality of life ; Questionnaires ; Risk analysis ; Risk factors ; Risk reduction ; Self examination (Medical) ; Skin diseases ; Suburban areas ; Surveys</subject><ispartof>PloS one, 2020-05, Vol.15 (5), p.e0231818-e0231818</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Westerlaken-van Ginkel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Westerlaken-van Ginkel et al 2020 Westerlaken-van Ginkel et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-348fe2f3a09b7fe515f2ca01e205f8630907b79c79ec6e13c03b63a7bb6938b3</citedby><cites>FETCH-LOGICAL-c692t-348fe2f3a09b7fe515f2ca01e205f8630907b79c79ec6e13c03b63a7bb6938b3</cites><orcidid>0000-0002-5247-2697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219708/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219708/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32401757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gall, Seana</contributor><creatorcontrib>Westerlaken-van Ginkel, Cornelia Doriene</creatorcontrib><creatorcontrib>Vonk, Judith M</creatorcontrib><creatorcontrib>Flokstra-de Blok, Bertine M J</creatorcontrib><creatorcontrib>Sprikkelman, Aline B</creatorcontrib><creatorcontrib>Koppelman, Gerard H</creatorcontrib><creatorcontrib>Dubois, Anthony E J</creatorcontrib><title>Likely questionnaire-diagnosed food allergy in 78, 890 adults from the northern Netherlands</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>It is challenging to define likely food allergy (FA) in large populations which limited the number of large studies regarding risk factors for FA.
We studied the prevalence and characteristics of self-reported FA (s-rFA) in the large, population-based Dutch Lifelines cohort and identified associated risk factors.
Likely food allergic cases (LikelyFA) were classified based on questionnaire reported characteristics consistent with FA. Subjects with atypical characteristics were classified as Indeterminate. We investigated 13 potential risk factors for LikelyFA such as birth mode and living on a farm and addressed health-related quality of life (H-RQOL).
Of the 78, 890 subjects, 12.1% had s-rFA of which 4.0% and 8.1% were classified as LikelyFA and Indeterminate, respectively. Younger age, female sex, asthma, eczema and nasal allergy increased the risk of LikelyFA (p-value range <1.00*10-250-1.29*10-7). Living in a small city/large village or suburb during childhood was associated with a higher risk of LikelyFA than living on a farm (p-value = 7.81*10-4 and p = 4.84*10-4, respectively). Subjects classified as Indeterminate more often reported depression and burn-out compared to those without FA (p-value = 1.46*10-4 and p = 8.39*10-13, respectively). No association was found with ethnicity, (duration of) breastfeeding, birth mode and reported eating disorder. Mental and physical component scores measuring H-RQOL were lower in both those classified as LikelyFA and Indeterminate compared to those without FA.
The prevalence of s-rFA among adults is considerable and one-third reports characteristics consistent with LikelyFA. Living on a farm decreased the risk of LikelyFA. The association of poorer H-RQOL as well as depression and burn-out with questionable self-perceived FA is striking and a priority for future study.</description><subject>Adults</subject><subject>Allergies</subject><subject>Allergy</subject><subject>Asthma</subject><subject>Biology and Life Sciences</subject><subject>Birth</subject><subject>Breast feeding</subject><subject>Breastfeeding & lactation</subject><subject>Childhood</subject><subject>Children</subject><subject>Classification</subject><subject>Diagnosis</subject><subject>Eating disorders</subject><subject>Eczema</subject><subject>Farms</subject><subject>Food</subject><subject>Food allergies</subject><subject>Food hypersensitivity</subject><subject>Health</subject><subject>Health risks</subject><subject>Health surveys</subject><subject>Identification methods</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Mental disorders</subject><subject>Minority & ethnic groups</subject><subject>Population</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Risk reduction</subject><subject>Self examination (Medical)</subject><subject>Skin diseases</subject><subject>Suburban 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questionnaire-diagnosed food allergy in 78, 890 adults from the northern Netherlands</title><author>Westerlaken-van Ginkel, Cornelia Doriene ; Vonk, Judith M ; Flokstra-de Blok, Bertine M J ; Sprikkelman, Aline B ; Koppelman, Gerard H ; Dubois, Anthony E J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-348fe2f3a09b7fe515f2ca01e205f8630907b79c79ec6e13c03b63a7bb6938b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adults</topic><topic>Allergies</topic><topic>Allergy</topic><topic>Asthma</topic><topic>Biology and Life Sciences</topic><topic>Birth</topic><topic>Breast feeding</topic><topic>Breastfeeding & lactation</topic><topic>Childhood</topic><topic>Children</topic><topic>Classification</topic><topic>Diagnosis</topic><topic>Eating disorders</topic><topic>Eczema</topic><topic>Farms</topic><topic>Food</topic><topic>Food allergies</topic><topic>Food 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One</addtitle><date>2020-05-13</date><risdate>2020</risdate><volume>15</volume><issue>5</issue><spage>e0231818</spage><epage>e0231818</epage><pages>e0231818-e0231818</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>It is challenging to define likely food allergy (FA) in large populations which limited the number of large studies regarding risk factors for FA.
We studied the prevalence and characteristics of self-reported FA (s-rFA) in the large, population-based Dutch Lifelines cohort and identified associated risk factors.
Likely food allergic cases (LikelyFA) were classified based on questionnaire reported characteristics consistent with FA. Subjects with atypical characteristics were classified as Indeterminate. We investigated 13 potential risk factors for LikelyFA such as birth mode and living on a farm and addressed health-related quality of life (H-RQOL).
Of the 78, 890 subjects, 12.1% had s-rFA of which 4.0% and 8.1% were classified as LikelyFA and Indeterminate, respectively. Younger age, female sex, asthma, eczema and nasal allergy increased the risk of LikelyFA (p-value range <1.00*10-250-1.29*10-7). Living in a small city/large village or suburb during childhood was associated with a higher risk of LikelyFA than living on a farm (p-value = 7.81*10-4 and p = 4.84*10-4, respectively). Subjects classified as Indeterminate more often reported depression and burn-out compared to those without FA (p-value = 1.46*10-4 and p = 8.39*10-13, respectively). No association was found with ethnicity, (duration of) breastfeeding, birth mode and reported eating disorder. Mental and physical component scores measuring H-RQOL were lower in both those classified as LikelyFA and Indeterminate compared to those without FA.
The prevalence of s-rFA among adults is considerable and one-third reports characteristics consistent with LikelyFA. Living on a farm decreased the risk of LikelyFA. The association of poorer H-RQOL as well as depression and burn-out with questionable self-perceived FA is striking and a priority for future study.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32401757</pmid><doi>10.1371/journal.pone.0231818</doi><tpages>e0231818</tpages><orcidid>https://orcid.org/0000-0002-5247-2697</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Allergies Allergy Asthma Biology and Life Sciences Birth Breast feeding Breastfeeding & lactation Childhood Children Classification Diagnosis Eating disorders Eczema Farms Food Food allergies Food hypersensitivity Health Health risks Health surveys Identification methods Medical research Medicine and Health Sciences Mental disorders Minority & ethnic groups Population Quality of life Questionnaires Risk analysis Risk factors Risk reduction Self examination (Medical) Skin diseases Suburban areas Surveys |
| title | Likely questionnaire-diagnosed food allergy in 78, 890 adults from the northern Netherlands |
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