Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats

Acute myocardial infarction (AMI) remains the most common cause of morbidity and mortality worldwide. The present study was directed to investigate the beneficial effects of benfotiamine pre- and post-treatments in isoproterenol (ISO)-induced MI in rats. Myocardial heart damage was induced by subcut...

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Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0232413
Hauptverfasser:	Ahmed, Lamiaa A, Hassan, Omnia F, Galal, Omneya, Mansour, Dina F, El-Khatib, Aiman
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Apoptosis Biology and Life Sciences Calcium-binding protein Cardiomyocytes Caspase-8 Chemical compounds Creatine kinase Creatinine Damage Diabetes Drug therapy Electrocardiography Enzyme inhibitors Enzymes Gelatinase B Glutathione Glutathione peroxidase Health aspects Heart Heart attack Heart attacks Inflammation Isoproterenol Kinases Laboratory animals Malondialdehyde Markers Medicine and Health Sciences Membrane proteins Metalloproteinase Morbidity Myocardial infarction NAD(P)H oxidase NADPH-diaphorase NF-κB protein Niacinamide Nicotinamide Nicotinamide adenine dinucleotide Oxidase Oxidases Oxidative stress p53 Protein Peroxidase Perturbation Pharmacology Pharmacy Phosphates Protein kinase C Protein kinases Proteins Purines Research and Analysis Methods Superoxide dismutase Superoxides Testing Therapeutic applications Toxicology Troponin Tumor proteins Vitamin B
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