Theoretical investigation of a genetic switch for metabolic adaptation

Membrane transporters carry key metabolites across the cell membrane and, from a resource standpoint, are hypothesized to be produced when necessary. The expression of membrane transporters in metabolic pathways is often upregulated by the transporter substrate. In E. coli, such systems include for...

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Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0226453-e0226453
Hauptverfasser:	Laxhuber, Kathrin S, Morrison, Muir J, Chure, Griffin, Belliveau, Nathan M, Strandkvist, Charlotte, Naughton, Kyle L, Phillips, Rob
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adaptation, Physiological - genetics Arabinose Binding Sites Bioengineering Biological Transport - genetics Biology Biology and Life Sciences Cell membranes Circuits Computer simulation Degradation E coli Engineering and Technology Enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Feedback Feedback loops Feedback, Physiological Gene expression Gene Expression Regulation, Bacterial Gene Regulatory Networks Genes Genes, Switch Genetic aspects Genetic regulation Genetic research Lactose Membrane proteins Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Membranes Metabolic pathways Metabolic regulation Metabolism Metabolites Models, Biological Monosaccharides Negative feedback Pentosyltransferases - genetics Pentosyltransferases - metabolism Physics Physiological aspects Positive feedback Promoter Regions, Genetic Proteins Ribonucleosides - metabolism RNA, Messenger - metabolism Stochastic Processes Stochasticity Substrates Systems analysis Trans-Activators - genetics Trans-Activators - metabolism Transcription (Genetics) Transcription activation Transcription factors Transcription, Genetic Transport Transport proteins Xanthines
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