Effects of miR-103 by negatively regulating SATB2 on proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells

The proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMScs) are modulated by a variety of microRNAs (miRNAs). SATB homeobox 2 (SATB2) is a critical transcription factor that contributes to maintain the balance of bone metabolism. However, it remains unclear...

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Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0232695-e0232695
Hauptverfasser:	Lv, Hao, Yang, Huashan, Wang, Yuanrui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alizarin Alkaline phosphatase Assaying Bioinformatics Biological markers Biology and Life Sciences Biomarkers Biomedical materials Bone diseases Bone marrow Bone turnover Cbfa-1 protein Cell differentiation Cell proliferation Cholecystokinin Computational biology Cybernetics Development and progression Differentiation (biology) Digital cameras Disease Diseases Gene expression Genes Genetic aspects Health aspects Hematopoietic stem cells Homeobox Hospitals Levels Luciferase Mesenchymal stem cells Messenger RNA Metabolism MicroRNA MicroRNAs miRNA Osteogenesis Osteoporosis Phosphatases Proteins Research and Analysis Methods RNA siRNA Stem cells Therapeutic applications Time Time dependence Transcription (Genetics) Transcription factors Transfection Trauma
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