Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells

In our search for bioactive mushrooms native to British Columbia, we determined that the ethanol extracts from fruiting bodies of the terrestrial polypore Albatrellus flettii had potent anti-cell viability activity. Using bioassay-guided fractionation, mass spectrometry and nuclear magnetic resonanc...

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Veröffentlicht in:	PloS one 2020-05, Vol.15 (5), p.e0231948
Hauptverfasser:	Yaqoob, Almas, Li, Wai Ming, Liu, Victor, Wang, Chuyi, Mackedenski, Sebastian, Tackaberry, Linda E, Massicotte, Hugues B, Egger, Keith N, Reimer, Kerry, Lee, Chow H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics Apoptosis Basidiocarps Basidiomycota - chemistry Bioassays Biochemistry Biological activity Biological assays Biology and Life Sciences Cancer Cancer cells Cell cycle Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cell viability Cloning Colon Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colorectal cancer Diagnostic imaging Domains Dose-Response Relationship, Drug Down-Regulation Ecosystems Ethanol Fluorescence Fluorescence polarization Fractionation Fruit bodies Gene expression Gene Expression Regulation, Neoplastic - drug effects Growth factors HT29 Cells Humans Insulin K-Ras protein Magnetic resonance Mass spectrometry Mass spectroscopy Medicine and Health Sciences Messenger RNA Molecular interactions Mushrooms Neomycin NMR Novels Nuclear magnetic resonance Phenols - pharmacology Physical Sciences Plant Extracts - chemistry Plant Extracts - pharmacology Protein binding Proto-Oncogene Proteins p21(ras) - genetics Research and analysis methods Resorcinols - pharmacology RNA RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Solvents Spectroscopy Terpenes - pharmacology Terrestrial environments Time Transcription Tumor cell lines
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