Effect of ovarian stimulation on the expression of piRNA pathway proteins
PIWI-interacting RNAs (piRNAs) play an important role in gametogenesis, fertility and embryonic development. The current study investigated the effect of different doses of pregnant mare serum gonadotrophin/human chorionic gonadotrophin (PMSG/hCG) and repeated ovarian stimulation (OS) on the express...
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| description | PIWI-interacting RNAs (piRNAs) play an important role in gametogenesis, fertility and embryonic development. The current study investigated the effect of different doses of pregnant mare serum gonadotrophin/human chorionic gonadotrophin (PMSG/hCG) and repeated ovarian stimulation (OS) on the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9, qnd Mitopld genes, which have crucial roles in the biogenesis and function of piRNAs. Here, we found that after treatment with 7.5 I.U. PMSG/hCG and two repeated rounds of OS, both the mRNA and protein levels of Tdrd9, Tdrd1 and Mael showed the greatest decrease in the ovarian tissue, but the plasma E2 levels showed the strongest increases (p |
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The current study investigated the effect of different doses of pregnant mare serum gonadotrophin/human chorionic gonadotrophin (PMSG/hCG) and repeated ovarian stimulation (OS) on the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9, qnd Mitopld genes, which have crucial roles in the biogenesis and function of piRNAs. Here, we found that after treatment with 7.5 I.U. PMSG/hCG and two repeated rounds of OS, both the mRNA and protein levels of Tdrd9, Tdrd1 and Mael showed the greatest decrease in the ovarian tissue, but the plasma E2 levels showed the strongest increases (p<0.05). However, we found that the Mitopld, Miwi and Mili gene levels were decreased significantly after treatment with 12.5 I.U. PMSG/hCG. Our results suggested that exogenous gonadotropin administration leads to a significant decrease in the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9 and Mitopld genes, which are critically important in the piRNA pathway, and the changes in the expression levels of Tdrd9, Tdrd1 and Mael may be associated with plasma E2 levels. New comprehensive studies are needed to reduce the potential effects of OS on the piRNA pathway, which silences transposable elements and maintains genome integrity, and to contribute to the safety of OS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0232629</identifier><identifier>PMID: 32365144</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Biosynthesis ; Deoxyribonucleic acid ; DNA ; DNA methylation ; EDTA ; Embryogenesis ; Embryology ; Embryonic development ; Embryonic growth stage ; Embryos ; Epigenetics ; Fertility ; Gametogenesis ; Gene expression ; Gene loci ; Genes ; Genomes ; Genomics ; Gonadotropins ; Histology ; In vitro fertilization ; Infertility ; Medicine ; Messenger RNA ; mRNA ; Operating systems (Software) ; Pituitary (anterior) ; Placental hormones ; Pregnant women ; Proteins ; Research and Analysis Methods ; RNA ; Silence ; Stimulation ; Table tennis ; Transposons</subject><ispartof>PloS one, 2020-05, Vol.15 (5), p.e0232629-e0232629</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Sari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Sari et al 2020 Sari et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-98a03968e6a6b616da3eb253c90f22bac37cb3491a28ecb2956e2a2acf43d2453</citedby><cites>FETCH-LOGICAL-c692t-98a03968e6a6b616da3eb253c90f22bac37cb3491a28ecb2956e2a2acf43d2453</cites><orcidid>0000-0003-3732-2102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197780/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197780/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32365144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Anbazhagan, Rajakumar</contributor><creatorcontrib>Sari, Ismail</creatorcontrib><creatorcontrib>Gumus, Erkan</creatorcontrib><creatorcontrib>Taskiran, Ahmet Sevki</creatorcontrib><creatorcontrib>Karakoc Sokmensuer, Lale</creatorcontrib><title>Effect of ovarian stimulation on the expression of piRNA pathway proteins</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>PIWI-interacting RNAs (piRNAs) play an important role in gametogenesis, fertility and embryonic development. The current study investigated the effect of different doses of pregnant mare serum gonadotrophin/human chorionic gonadotrophin (PMSG/hCG) and repeated ovarian stimulation (OS) on the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9, qnd Mitopld genes, which have crucial roles in the biogenesis and function of piRNAs. Here, we found that after treatment with 7.5 I.U. PMSG/hCG and two repeated rounds of OS, both the mRNA and protein levels of Tdrd9, Tdrd1 and Mael showed the greatest decrease in the ovarian tissue, but the plasma E2 levels showed the strongest increases (p<0.05). However, we found that the Mitopld, Miwi and Mili gene levels were decreased significantly after treatment with 12.5 I.U. PMSG/hCG. Our results suggested that exogenous gonadotropin administration leads to a significant decrease in the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9 and Mitopld genes, which are critically important in the piRNA pathway, and the changes in the expression levels of Tdrd9, Tdrd1 and Mael may be associated with plasma E2 levels. New comprehensive studies are needed to reduce the potential effects of OS on the piRNA pathway, which silences transposable elements and maintains genome integrity, and to contribute to the safety of OS.</description><subject>Biology and Life Sciences</subject><subject>Biosynthesis</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>EDTA</subject><subject>Embryogenesis</subject><subject>Embryology</subject><subject>Embryonic development</subject><subject>Embryonic growth stage</subject><subject>Embryos</subject><subject>Epigenetics</subject><subject>Fertility</subject><subject>Gametogenesis</subject><subject>Gene expression</subject><subject>Gene loci</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Gonadotropins</subject><subject>Histology</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Medicine</subject><subject>Messenger 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One</addtitle><date>2020-05-04</date><risdate>2020</risdate><volume>15</volume><issue>5</issue><spage>e0232629</spage><epage>e0232629</epage><pages>e0232629-e0232629</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>PIWI-interacting RNAs (piRNAs) play an important role in gametogenesis, fertility and embryonic development. The current study investigated the effect of different doses of pregnant mare serum gonadotrophin/human chorionic gonadotrophin (PMSG/hCG) and repeated ovarian stimulation (OS) on the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9, qnd Mitopld genes, which have crucial roles in the biogenesis and function of piRNAs. Here, we found that after treatment with 7.5 I.U. PMSG/hCG and two repeated rounds of OS, both the mRNA and protein levels of Tdrd9, Tdrd1 and Mael showed the greatest decrease in the ovarian tissue, but the plasma E2 levels showed the strongest increases (p<0.05). However, we found that the Mitopld, Miwi and Mili gene levels were decreased significantly after treatment with 12.5 I.U. PMSG/hCG. Our results suggested that exogenous gonadotropin administration leads to a significant decrease in the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9 and Mitopld genes, which are critically important in the piRNA pathway, and the changes in the expression levels of Tdrd9, Tdrd1 and Mael may be associated with plasma E2 levels. New comprehensive studies are needed to reduce the potential effects of OS on the piRNA pathway, which silences transposable elements and maintains genome integrity, and to contribute to the safety of OS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32365144</pmid><doi>10.1371/journal.pone.0232629</doi><tpages>e0232629</tpages><orcidid>https://orcid.org/0000-0003-3732-2102</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Biosynthesis Deoxyribonucleic acid DNA DNA methylation EDTA Embryogenesis Embryology Embryonic development Embryonic growth stage Embryos Epigenetics Fertility Gametogenesis Gene expression Gene loci Genes Genomes Genomics Gonadotropins Histology In vitro fertilization Infertility Medicine Messenger RNA mRNA Operating systems (Software) Pituitary (anterior) Placental hormones Pregnant women Proteins Research and Analysis Methods RNA Silence Stimulation Table tennis Transposons |
| title | Effect of ovarian stimulation on the expression of piRNA pathway proteins |
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