Analyzing structural alterations of mitochondrial intermembrane space superoxide scavengers cytochrome-c and SOD1 after methylglyoxal treatment

Mitochondria are quantitatively the most important sources of reactive oxygen species (ROS) which are formed as by-products during cellular respiration. ROS generation occurs when single electrons are transferred to molecular oxygen. This leads to a number of different ROS types, among them superoxi...

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Veröffentlicht in:	PloS one 2020-04, Vol.15 (4), p.e0232408-e0232408
Hauptverfasser:	Mercado-Uribe, Hilda, Andrade-Medina, Mariana, Espinoza-Rodríguez, Juan Horacio, Carrillo-Tripp, Mauricio, Scheckhuber, Christian Quintus
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Agglomeration Antioxidants Binding sites Biology and Life Sciences Calorimetry Carbonyl compounds Carbonyls Circular dichroism Copper Cytochrome Cytochrome c Cytochromes Detoxification Diabetes mellitus Dichroism Differential scanning calorimetry Emission measurements Energy metabolism Enzymes Etiology Experiments Fluorescence Glycosylation Heat measurement Metabolism Mitochondria Mutation Neurodegeneration Oxygen Physical Sciences Protein structure Proteins Pyruvaldehyde Reactive oxygen species Research and Analysis Methods Scavengers Secondary structure Single electrons Superoxide dismutase
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