The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice

The NUP98 and NUP214 nucleoporins (NUPs) are recurrently fused to heterologous proteins in leukemia. The resulting chimeric oncoproteins retain the phenylalanine-glycine (FG) repeat motifs of the NUP moiety that mediate interaction with the nuclear export receptor Crm1. NUP fusion leukemias are char...

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Veröffentlicht in:	PloS one 2020-04, Vol.15 (4), p.e0232036
Hauptverfasser:	Lavau, Catherine P, Aumann, Waitman K, Sze, Sei-Gyung K, Gupta, Veerain, Ripple, Katelyn, Port, Sarah A, Kehlenbach, Ralph H, Wechsler, Daniel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino acids Animals B cells Biology and Life Sciences Blood diseases Cancer Cell Line Chromatin Exportin 1 Protein Fusion protein Gene expression Gene Expression Regulation, Neoplastic Gene mutation Genes Genetic aspects Glycine Hemopoiesis Homeodomain Proteins - genetics HOXA gene Immunoprecipitation Karyopherins - metabolism Leukemia Leukemia - genetics Leukemia - metabolism Leukemia - pathology Leukemogenesis Liver transplants Medicine and Health Sciences Mice Molecular biology Mutagenesis, Site-Directed Mutation Myeloid Ecotropic Viral Integration Site 1 Protein - genetics Myeloid leukemia Neoplasm Transplantation Nuclear Pore Complex Proteins - chemistry Nuclear Pore Complex Proteins - genetics Nuclear transport Nucleoporins Oncogene Proteins, Fusion - chemistry Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Pathogenesis Pediatrics Phenylalanine Point Mutation Protein binding Proteins Receptors, Cytoplasmic and Nuclear - metabolism Sequestosome-1 Protein - genetics Stem cell transplantation Transcription factors Up-Regulation
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