The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy

The prognosis for people with the high-grade brain tumor glioblastoma is very poor, due largely to low cell death in response to genotoxic therapy. The transcription factor BCL6, a protein that normally suppresses the DNA damage response during immune cell maturation, and a known driver of B-cell ly...

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Veröffentlicht in:	PloS one 2020-04, Vol.15 (4), p.e0231470-e0231470
Hauptverfasser:	Fabre, Marie-Sophie, Stanton, Nicole M, Slatter, Tania L, Lee, Samuel, Senanayake, Dinindu, Gordon, Rosemary M A, Castro, M Leticia, Rowe, Matthew R, Taha, Ahmad, Royds, Janice A, Hung, Noelyn, Melnick, Ari M, McConnell, Melanie J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Apoptosis B-cell lymphoma Bcl-6 protein Biology and Life Sciences Brain cancer Brain tumors Cell cycle Cell death Cell survival Damage Defects Deoxyribonucleic acid DNA DNA damage DNA repair Ethics Ethylenediaminetetraacetic acid Gene expression Genes Genetic aspects Genetic transcription Genotoxicity Glioblastoma Glioblastoma cells Glioblastoma multiforme Health aspects Immune system Ionizing radiation Kinases Lymphocytes B Lymphoma Medical prognosis Medical research Medicine and Health Sciences Methylene blue Mutation Non-Hodgkin's lymphomas Oncogenes Pathology Physical Sciences Prognosis Radiation Research and Analysis Methods Survival Temozolomide Therapeutic applications Therapy Tumor cell lines Tumors
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