Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis
Liver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify p...
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| creator | Benz, Fabian Bogen, Andreas Praktiknjo, Michael Jansen, Christian Meyer, Carsten Wree, Alexander Demir, Muenevver Loosen, Sven Vucur, Mihael Schierwagen, Robert Tacke, Frank Trebicka, Jonel Roderburg, Christoph |
| description | Liver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis. |
| doi_str_mv | 10.1371/journal.pone.0231701 |
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Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0231701</identifier><identifier>PMID: 32302330</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Authorship ; Biology and Life Sciences ; Biomarkers ; Biomedical materials ; Bone sialoprotein ; Cirrhosis ; Correlation ; Diagnostic systems ; Disease ; Etiology ; Gastroenterology ; Health risks ; Hepatitis ; Hepatology ; Hospitals ; Hypertension ; Internal medicine ; Liver ; Liver cirrhosis ; Liver diseases ; Markers ; Medicine ; Medicine and Health Sciences ; Mortality ; Osteopontin ; Patients ; Portal vein ; Prognosis ; Serum levels ; Siblings ; Veins & arteries</subject><ispartof>PloS one, 2020-04, Vol.15 (4), p.e0231701-e0231701</ispartof><rights>2020 Benz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis.</description><subject>Authorship</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomedical materials</subject><subject>Bone sialoprotein</subject><subject>Cirrhosis</subject><subject>Correlation</subject><subject>Diagnostic systems</subject><subject>Disease</subject><subject>Etiology</subject><subject>Gastroenterology</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Internal medicine</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Markers</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Osteopontin</subject><subject>Patients</subject><subject>Portal 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levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis</title><author>Benz, Fabian ; Bogen, Andreas ; Praktiknjo, Michael ; Jansen, Christian ; Meyer, Carsten ; Wree, Alexander ; Demir, Muenevver ; Loosen, Sven ; Vucur, Mihael ; Schierwagen, Robert ; Tacke, Frank ; Trebicka, Jonel ; Roderburg, Christoph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-6405bea75dcd6ef2f29d5473b74adc09e0bb1540bbeb255870a4edca1705588a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Authorship</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomedical materials</topic><topic>Bone sialoprotein</topic><topic>Cirrhosis</topic><topic>Correlation</topic><topic>Diagnostic systems</topic><topic>Disease</topic><topic>Etiology</topic><topic>Gastroenterology</topic><topic>Health 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Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32302330</pmid><doi>10.1371/journal.pone.0231701</doi><orcidid>https://orcid.org/0000-0003-4411-7617</orcidid><orcidid>https://orcid.org/0000-0001-6206-0226</orcidid><orcidid>https://orcid.org/0000-0002-2195-3666</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Authorship Biology and Life Sciences Biomarkers Biomedical materials Bone sialoprotein Cirrhosis Correlation Diagnostic systems Disease Etiology Gastroenterology Health risks Hepatitis Hepatology Hospitals Hypertension Internal medicine Liver Liver cirrhosis Liver diseases Markers Medicine Medicine and Health Sciences Mortality Osteopontin Patients Portal vein Prognosis Serum levels Siblings Veins & arteries |
| title | Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis |
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