The influence of red blood cell deformability on hematocrit profiles and platelet margination
The influence of red blood cell (RBC) deformability in whole blood on platelet margination is investigated using confocal microscopy measurements of flowing human blood and cell resolved blood flow simulations. Fluorescent platelet concentrations at the wall of a glass chamber are measured using con...
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| creator | Czaja, Benjamin Gutierrez, Mario Závodszky, Gábor de Kanter, David Hoekstra, Alfons Eniola-Adefeso, Omolola |
| description | The influence of red blood cell (RBC) deformability in whole blood on platelet margination is investigated using confocal microscopy measurements of flowing human blood and cell resolved blood flow simulations. Fluorescent platelet concentrations at the wall of a glass chamber are measured using confocal microscopy with flowing human blood containing varying healthy-to-stiff RBC fractions. A decrease is observed in the fluorescent platelet signal at the wall due to the increase of stiffened RBCs in flow, suggesting a decrease of platelet margination due to an increased fraction of stiffened RBCs present in the flow. In order to resolve the influence of stiffened RBCs on platelet concentration at the channel wall, cell-pair and bulk flow simulations are performed. For homogeneous collisions between RBC pairs, a decrease in final displacement after a collision with increasing membrane stiffness is observed. In heterogeneous collisions between healthy and stiff RBC pairs, it is found that the stiffened RBC is displaced most. The influence of RBC deformability on collisions between RBCs and platelets was found to be negligible due to their size and mass difference. For a straight vessel geometry with varying healthy-to-stiff RBC ratios, a decrease was observed in the red blood cell-free layer and platelet margination due to an increase in stiffened RBCs present in flow. |
| doi_str_mv | 10.1371/journal.pcbi.1007716 |
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Fluorescent platelet concentrations at the wall of a glass chamber are measured using confocal microscopy with flowing human blood containing varying healthy-to-stiff RBC fractions. A decrease is observed in the fluorescent platelet signal at the wall due to the increase of stiffened RBCs in flow, suggesting a decrease of platelet margination due to an increased fraction of stiffened RBCs present in the flow. In order to resolve the influence of stiffened RBCs on platelet concentration at the channel wall, cell-pair and bulk flow simulations are performed. For homogeneous collisions between RBC pairs, a decrease in final displacement after a collision with increasing membrane stiffness is observed. In heterogeneous collisions between healthy and stiff RBC pairs, it is found that the stiffened RBC is displaced most. The influence of RBC deformability on collisions between RBCs and platelets was found to be negligible due to their size and mass difference. For a straight vessel geometry with varying healthy-to-stiff RBC ratios, a decrease was observed in the red blood cell-free layer and platelet margination due to an increase in stiffened RBCs present in flow.</description><identifier>ISSN: 1553-7358</identifier><identifier>ISSN: 1553-734X</identifier><identifier>EISSN: 1553-7358</identifier><identifier>DOI: 10.1371/journal.pcbi.1007716</identifier><identifier>PMID: 32163405</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Blood ; Blood flow ; Blood platelets ; Blood vessels ; Chemical engineering ; Collisions ; Confocal microscopy ; Deformability ; Deformation ; Diabetes ; Erythrocytes ; Experiments ; Flow ; Flow (Dynamics) ; Flow simulation ; Fluorescence ; Formability ; Gutierrez, Mario ; Hematocrit ; Hemoglobin ; Informatics ; Medicine and Health Sciences ; Microscopy ; Oxidative stress ; Physical Sciences ; Platelets ; Red blood cells ; Research and Analysis Methods ; Rheology ; Sickle cell anemia ; Software ; Stiffness ; Supervision</subject><ispartof>PLoS computational biology, 2020-03, Vol.16 (3), p.e1007716-e1007716</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Czaja et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Fluorescent platelet concentrations at the wall of a glass chamber are measured using confocal microscopy with flowing human blood containing varying healthy-to-stiff RBC fractions. A decrease is observed in the fluorescent platelet signal at the wall due to the increase of stiffened RBCs in flow, suggesting a decrease of platelet margination due to an increased fraction of stiffened RBCs present in the flow. In order to resolve the influence of stiffened RBCs on platelet concentration at the channel wall, cell-pair and bulk flow simulations are performed. For homogeneous collisions between RBC pairs, a decrease in final displacement after a collision with increasing membrane stiffness is observed. In heterogeneous collisions between healthy and stiff RBC pairs, it is found that the stiffened RBC is displaced most. The influence of RBC deformability on collisions between RBCs and platelets was found to be negligible due to their size and mass difference. 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red blood cell (RBC) deformability in whole blood on platelet margination is investigated using confocal microscopy measurements of flowing human blood and cell resolved blood flow simulations. Fluorescent platelet concentrations at the wall of a glass chamber are measured using confocal microscopy with flowing human blood containing varying healthy-to-stiff RBC fractions. A decrease is observed in the fluorescent platelet signal at the wall due to the increase of stiffened RBCs in flow, suggesting a decrease of platelet margination due to an increased fraction of stiffened RBCs present in the flow. In order to resolve the influence of stiffened RBCs on platelet concentration at the channel wall, cell-pair and bulk flow simulations are performed. For homogeneous collisions between RBC pairs, a decrease in final displacement after a collision with increasing membrane stiffness is observed. In heterogeneous collisions between healthy and stiff RBC pairs, it is found that the stiffened RBC is displaced most. The influence of RBC deformability on collisions between RBCs and platelets was found to be negligible due to their size and mass difference. For a straight vessel geometry with varying healthy-to-stiff RBC ratios, a decrease was observed in the red blood cell-free layer and platelet margination due to an increase in stiffened RBCs present in flow.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32163405</pmid><doi>10.1371/journal.pcbi.1007716</doi><orcidid>https://orcid.org/0000-0003-1140-5698</orcidid><orcidid>https://orcid.org/0000-0002-8728-6608</orcidid><orcidid>https://orcid.org/0000-0003-2224-3081</orcidid><orcidid>https://orcid.org/0000-0003-0150-0229</orcidid><orcidid>https://orcid.org/0000-0003-2803-5267</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Blood Blood flow Blood platelets Blood vessels Chemical engineering Collisions Confocal microscopy Deformability Deformation Diabetes Erythrocytes Experiments Flow Flow (Dynamics) Flow simulation Fluorescence Formability Gutierrez, Mario Hematocrit Hemoglobin Informatics Medicine and Health Sciences Microscopy Oxidative stress Physical Sciences Platelets Red blood cells Research and Analysis Methods Rheology Sickle cell anemia Software Stiffness Supervision |
| title | The influence of red blood cell deformability on hematocrit profiles and platelet margination |
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