Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study

Lipid levels are important markers for the development of cardio-metabolic diseases. Although hundreds of associated loci have been identified through genetic association studies, the contribution of genetic factors to variation in lipids is not fully understood, particularly in U.S. minority groups...

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Veröffentlicht in:	PLoS genetics 2020-03, Vol.16 (3), p.e1008684
Hauptverfasser:	Hu, Yao, Graff, Mariaelisa, Haessler, Jeffrey, Buyske, Steven, Bien, Stephanie A, Tao, Ran, Highland, Heather M, Nishimura, Katherine K, Zubair, Niha, Lu, Yingchang, Verbanck, Marie, Hilliard, Austin T, Klarin, Derek, Damrauer, Scott M, Ho, Yuk-Lam, Wilson, Peter W F, Chang, Kyong-Mi, Tsao, Philip S, Cho, Kelly, O'Donnell, Christopher J, Assimes, Themistocles L, Petty, Lauren E, Below, Jennifer E, Dikilitas, Ozan, Schaid, Daniel J, Kosel, Matthew L, Kullo, Iftikhar J, Rasmussen-Torvik, Laura J, Jarvik, Gail P, Feng, Qiping, Wei, Wei-Qi, Larson, Eric B, Mentch, Frank D, Almoguera, Berta, Sleiman, Patrick M, Raffield, Laura M, Correa, Adolfo, Martin, Lisa W, Daviglus, Martha, Matise, Tara C, Ambite, Jose Luis, Carlson, Christopher S, Do, Ron, Loos, Ruth J F, Wilkens, Lynne R, Le Marchand, Loic, Haiman, Chris, Stram, Daniel O, Hindorff, Lucia A, North, Kari E, Kooperberg, Charles, Cheng, Iona, Peters, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Analysis Authorship Biology and Life Sciences Cancer Children & youth Databases, Genetic Diseases Environmental science Epidemiology Europeans Female Funding Gene mapping Genes Genetic diversity Genetic factors Genetics Genome-Wide Association Study - methods Genomes Genomics Genotype Health care policy Health sciences Hospitals Humans Lipids Lipids - analysis Lipids - blood Lipids - genetics Male Medical research Metabolic disorders Metagenomics - methods Minority & ethnic groups Minority Groups Multifactorial Inheritance - genetics Novels People and Places Phenotype Physical Sciences Polygenic inheritance Polymorphism, Single Nucleotide - genetics Population genetics Population studies Precision medicine Preventive medicine Public health Racial Groups - genetics Research and Analysis Methods Software Supervision Type 2 diabetes United States - epidemiology Veterans
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