Alcelaphine herpesvirus 1 genes A7 and A8 regulate viral spread and are essential for malignant catarrhal fever

Alcelaphine herpesvirus 1 (AlHV-1) is a gammaherpesvirus that is carried asymptomatically by wildebeest. Upon cross-species transmission to other ruminants, including domestic cattle, AlHV-1 induces malignant catarrhal fever (MCF), which is a fatal lymphoproliferative disease resulting from prolifer...

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Veröffentlicht in:	PLoS pathogens 2020-03, Vol.16 (3), p.e1008405-e1008405
Hauptverfasser:	Myster, Françoise, Gong, Mei-Jiao, Javaux, Justine, Suárez, Nicolás M, Wilkie, Gavin S, Connelley, Tim, Vanderplasschen, Alain, Davison, Andrew J, Dewals, Benjamin G
Format:	Artikel
Sprache:	eng
Schlagworte:	Attenuation B cells Beef cattle Biology and life sciences CD8 antigen Cell culture Cell lines Cell proliferation Disease prevention Diseases Embryos Epstein-Barr virus Fever Genes Genetic research Genomes Genomics Glycoproteins Health aspects Immunology Immunoproliferative diseases Infections Laboratories Latent infection Life sciences Lymphocytes Lymphocytes T Lymphoma Malignant catarrhal fever Medicine and Health Sciences Médecine vétérinaire & santé animale Nose Nucleotide sequence Parasitic diseases Pathogenesis Periodical publishing Propagation Rabbits Research and analysis methods Sciences du vivant Syncytia T cells Tropism Veterinary medicine Veterinary medicine & animal health Viruses
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